Sihan Wu,Vineet Bafna,Howard Y Chang et al.
Sihan Wu et al.
Human genes are arranged on 23 pairs of chromosomes, but in cancer, tumor-promoting genes and regulatory elements can free themselves from chromosomes and relocate to circular, extrachromosomal pieces of DNA (ecDNA). ecDNA, because of its n...
Marcelle de Carvalho Ribeiro,Gyongyi Szabo
Marcelle de Carvalho Ribeiro
The involvement of inflammasomes in the proinflammatory response observed in chronic liver diseases, such as alcohol-associated liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD), is widely recognized. Although there are diffe...
Candace C Liu,Erin F McCaffrey,Noah F Greenwald et al.
Candace C Liu et al.
Next-generation tools for multiplexed imaging have driven a new wave of innovation in understanding how single-cell function and tissue structure are interrelated. In previous work, we developed multiplexed ion beam imaging by time of fligh...
In Vivo Dynamics of the Latent Reservoir for HIV-1: New Insights and Implications for Cure [0.03%]
HIV-1潜伏库的体内动力学：新见解及其对治愈的意义
Janet D Siliciano,Robert F Siliciano
Janet D Siliciano
Although antiretroviral therapy (ART) can reduce viremia to below the limit of detection and allow persons living with HIV-1 (PLWH) to lead relatively normal lives, viremia rebounds when treatment is interrupted. Rebound reflects viral pers...
Antonios Papanicolau-Sengos,Kenneth Aldape
Antonios Papanicolau-Sengos
Histomorphology has been a mainstay of cancer diagnosis in anatomic pathology for many years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct to increase accuracy of pathological diagnosis. Genome-wide...
Molecular Pathogenesis of Gastrointestinal Stromal Tumor: A Paradigm for Personalized Medicine [0.03%]
胃肠间质肿瘤的分子病理学：个性化医学的一个范例
Josephine K Dermawan,Brian P Rubin
Josephine K Dermawan
Over the past three to four decades, the molecular pathogenesis of gastrointestinal stromal tumors (GISTs) has been elucidated in great detail. In this review, we discuss the biological genesis of GISTs, identification of the various primar...
Tatyana V Masyuk,Anatoliy I Masyuk,Nicholas F LaRusso
Tatyana V Masyuk
Polycystic liver disease (PLD) is a group of genetic disorders characterized by progressive development of cholangiocyte-derived fluid-filled hepatic cysts. PLD is the most common manifestation of autosomal dominant and autosomal recessive ...
Julia E Rood,Edward M Behrens
Julia E Rood
Autoinflammation describes a collection of diverse diseases caused by indiscriminate activation of the immune system in an antigen-independent manner. The rapid advancement of genetic diagnostics has allowed for the identification of a wide...
A Balancing Act: p53 Activity from Tumor Suppression to Pathology and Therapeutic Implications [0.03%]
精妙的平衡：p53活性从肿瘤抑制到病理及治疗意义中的作用
Mengxiong Wang,Laura D Attardi
Mengxiong Wang
TP53, encoding the p53 transcription factor, is the most frequently mutated tumor suppressor gene across all human cancer types. While p53 has long been appreciated to induce antiproliferative cell cycle arrest, apoptosis, and senescence pr...
Ji-Yeon Shin,Howard J Worman
Ji-Yeon Shin
The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear pore complexes. Laminopathies are diseases caused by mutations in genes encoding protein components of the lamina and these other nuclear envelope substr...