Methylphenidate Inhibits the Development of Myopia by Altering Dopamine and Norepinephrine Reuptake [0.03%]
甲基苯环丙胺通过改变多巴胺和去甲肾上腺素的再摄取抑制近视的发展
Cindy Karouta,Kate Thomson,Ian Morgan et al.
Cindy Karouta et al.
Purpose: Dopaminergic dysregulation plays a critical role in myopia development in animal models. Although its relevance to human myopia remains uncertain, the observation that methylphenidate hydrochloride (MPH)-a dopami...
RPE65 Variant p.(E519K) Causes a Novel Dominant Adult-Onset Maculopathy in 83 Affected Individuals [0.03%]
RPE65变异p.(E519K)导致了83例患者的新型成年型黄斑变性
Eline Van Vooren,Filip Van Den Broeck,Quinten Mahieu et al.
Eline Van Vooren et al.
Purpose: Recessive RPE65-associated retinopathy is a well-known target for gene therapy, whereas dominant RPE65-associated retinopathy, due to the Irish founder variant p.(D477G), has been reported only once until now and...
Ebbinghaus Illusion Distortions in Amblyopia: Impairments of Visual Size Processing and Interocular Integration [0.03%]
弱视中的艾宾浩斯错觉失真：视觉大小处理和双眼融合障碍
Changwu Tan,Xi Wang,Tong Liu et al.
Changwu Tan et al.
Purpose: The perceived size of an object can be manipulated by its surroundings. In the current study, we wanted to investigate whether amblyopic patients have normal object size perception and how their perception is aff...
Independent Effects of Axial Length and Intraocular Pressure on the Highly Myopic Optic Nerve Head [0.03%]
轴长度和眼压对高度近视视盘独立影响的不同效应
Maverick Wenhao Wong,Crystal Chong,Swati Sharma et al.
Maverick Wenhao Wong et al.
Purpose: The purpose of this study was to investigate associations among intraocular pressure (IOP), axial length (AXL), and optic nerve head (ONH) characteristics in highly myopic eyes. ...
Kaempferol Alleviates Dry Eye Disease Via Modulation of the IDH3B/CCAR2/IKBKB Axis [0.03%]
山柰酚通过调节IDH3B/CCAR2/IKBKB轴缓解干眼病
Shuyan Zhang,Yongyi Sha,Yun Xie et al.
Shuyan Zhang et al.
Purpose: Dry eye disease (DED), a multifactorial ocular surface disorder characterized by tear film instability and hyperosmolarity, significantly compromises patients' quality of life. This study evaluates the therapeuti...
Targeting RPE Senescence Via Suppressing IL-6/IL-6R Signaling for Treating Retinal Degenerative Diseases [0.03%]
通过抑制白介素-6/白介素-6受体信号转导靶向视网膜色素上皮细胞衰老以治疗视网膜退行性疾病
Tian Zhou,Ziqi Yang,Biyan Ni et al.
Tian Zhou et al.
Purpose: Progressive dysfunction of retinal pigment epithelium (RPE) cells is a crucial factor for retinal degeneration, leading to irreversible blindness with limited therapeutic options. Cellular senescence of RPE cells...
Endothelial-Pericyte Interactions Regulate Angiogenesis Via VEGFR2 Signaling During Retinal Development and Disease [0.03%]
内皮细胞-周细胞相互作用通过VEGFR2信号调控视网膜发育和疾病中的血管生成
Ying-Yu Lin,Emily Warren,Bria L Macklin et al.
Ying-Yu Lin et al.
Purpose: Endothelial-pericyte interaction disruption causes vascular dropout and pathological angiogenesis, severely impacting visual function in ocular microvascular diseases. This study examines VEGF receptor 2 (VEGFR2)...
Exon Skipping Therapy Restores Ciliary Function in USH2A-Related Retinal Degeneration [0.03%]
用于USH2A相关视网膜变性的外显子跳跃疗法恢复纤毛功能
Wuyi Li,Yamei Li,Yunyu Zhou et al.
Wuyi Li et al.
Purpose: This study aimed to evaluate the exon-skipping efficacy and safety of an antisense oligonucleotide (AON) targeting USH2A exon 13 across multiple models, including the Rb1 cell line, humanized USH2A-e13 transgenic...
Association Between Pigmentation Heritage and Susceptibility to Experimentally Induced Myopia: Crossbreeding Insights From Albino and Pigmented Guinea Pigs [0.03%]
色素遗传与实验性诱导近视易感性的关联：来自白色豚鼠和色素豚鼠杂交的见解
Liqin Jiang,Yee Shan Dan,William E Myles et al.
Liqin Jiang et al.
Purpose: To investigate how pigmentation heritage affects susceptibility to form deprivation myopia (FDM) through crossbreeding myopia-susceptible albino and myopia-resistant pigmented guinea pigs (GPs). ...
Small Extracellular Vesicle Treatment of Trabecular Meshwork Fibrosis: 2D/3D In Vitro and In Vivo Analyses [0.03%]
小细胞外囊泡治疗小梁网纤维化：体外和体内2D/3D分析
Yufan Jiang,Yutong Che,Yuning Zhang et al.
Yufan Jiang et al.
Purpose: Fibrosis of the trabecular meshwork (TM) is a key pathological mechanism in POAG. Small extracellular vesicles (sEVs), a type of extracellular secretion, have various functions, such as antifibrotic effects and i...