Inflammatory Myeloid Cell Resurgence and Impaired Pro-Resolution Macrophage Maintenance Characterize Chronic Corneal Alkali Burn [0.03%]
慢性角膜碱烧伤的炎症髓样细胞复苏和促消退型巨噬细胞维持功能障碍的特征
Yunjin Lee,Young In Yun,Soo Jin Lee et al.
Yunjin Lee et al.
Purpose: To investigate longitudinal cellular and molecular immune remodeling during the transition from acute injury to chronic immunopathology after severe corneal alkali burn. ...
SPARC Promotes Corneal Epithelial Wound Healing Through β-catenin Nuclear Translocation and c-Met Activation [0.03%]
SPARC通过β-连环蛋白核转位和c-Met活化促进角膜上皮伤口愈合
Meihua Zhang,Di Yang,Lu Wang et al.
Meihua Zhang et al.
Purpose: To investigate the molecular mechanism through which secreted protein acidic and rich in cysteine (SPARC) facilitates corneal epithelial wound healing via the β-catenin/c-Met signaling pathway. ...
Defining a Novel RPGR Phenotype of Sector Retinitis Pigmentosa With Cone Dystrophy [0.03%]
一种新型RPGR表型的局灶性视网膜色素变性和锥体营养不良定义病例
Maram E A Abdalla Elsayed,Omar A Mahroo,Andrew Webster et al.
Maram E A Abdalla Elsayed et al.
Purpose: RPGRORF15-associated retinal degeneration is characterized by clinical and genetic heterogeneity: Proximal mutations typically result in rod-cone dystrophy, distal mutations in cone-dominated disease, and mutatio...
Observational Study
Investigative ophthalmology & visual science. 2026 Aug 3;67(10):24. DOI:10.1167/iovs.67.10.24 2026
The Matricellular Protein CCN1 Induces Corneal Stromal Cells Senescence and Inflammation to Trigger Extracellular Matrix Remodeling in Keratoconus [0.03%]
角膜营养不良中基质细胞衰老和炎症诱导角膜细胞外基质重塑的机制研究
Lei Zhang,Chaoqun Wei,Yifei Li et al.
Lei Zhang et al.
Purpose: Keratoconus (KC) is a multifactorial corneal degenerative disorder characterized by reduced extracellular matrix (ECM) and cellular content. This study investigates the role and mechanism of cellular communicatio...
Maternal High-Fat Diet Induces Sex- and Estrous Cycle-Specific Glial Dysregulation in the Peripheral Offspring Retina [0.03%]
高脂饮食诱导的母体对后代外周视网膜胶质调节的性别和动情周期特异性的影响
Gintare Urbonaite,Patricija Cepauskyte,Neda I Biliute et al.
Gintare Urbonaite et al.
Purpose: A maternal high-fat diet (mHFD) induces metabolic disturbances that lead to inflammatory responses in the offspring's brain. The retina, as part of the central nervous system, may be similarly affected. This stud...
Epigenetic Modulation of Thyroid-Stimulating Hormone Receptor Expression in Orbital Fibroblasts From Graves' Ophthalmopathy: Target for Treatment [0.03%]
Graves眼病轨道成纤维细胞的促甲状腺激素受体表观遗传调控及治疗靶点
Rajit Chompoowong,Pimchanok Phankeaw,Apinya Suwannavong et al.
Rajit Chompoowong et al.
Purpose: This study aims to investigate the expression and function of DNA methyltransferases (DNMTs) and histone methyltransferase EZH2 in regulating the expression of thyroid-stimulating hormone receptor (TSHR) and fibr...
Exploring Endotoxemia in Age-Related Macular Degeneration, Glaucoma, and Diabetic Retinopathy [0.03%]
年龄相关性黄斑变性、青光眼和糖尿病视网膜病变的内毒素血症探究
Petra Pei Larsen,Morgane Linard,Cédric Schweitzer et al.
Petra Pei Larsen et al.
Lipopolysaccharide (LPS), a component of Gram-negative bacteria, is a potent activator of the innate immune system and has been implicated in the pathogenesis of eye diseases, including age-related macular degeneration (AMD), primary open-a...
Directional Association Between Perilesional Fundus Autofluorescence and Geographic Atrophy Border Expansion [0.03%]
黄斑周围自发荧光与地理萎缩边缘扩展之间的方向性关联
Shinichiro Chujo,Alberto Quarta,Rouzbeh Abbasgholizadeh et al.
Shinichiro Chujo et al.
Purpose: The purpose of this study was to evaluate the directional association between perilesional fundus autofluorescence (FAF) intensity and geographic atrophy (GA) border expansion. ...
Macular Choriocapillaris and Retinal Microvascular Alterations Across the Prediabetes-Early Type 2 Diabetes Continuum [0.03%]
糖尿病前期至早期二型糖尿病阶段视网膜脉络膜微血管变化的研究
Fang Zheng,Yueheng Hong,Jacqueline Chua et al.
Fang Zheng et al.
Purpose: To characterize macular microvascular alterations across the dysglycemia spectrum, from prediabetes (pre-DM) to early type 2 diabetes (T2DM), before clinically detectable diabetic retinopathy develops. ...