Importance of Type and Direction of Eyelid Sliding to Mimic Blinking In Vitro for Dry Eye Disease and Contact Lens Research [0.03%]
Yong Chen,Hans J Kaper,Theo van Kooten et al.
Yong Chen et al.
Purpose: Establish a physiologically relevant in vitro ocular friction mode that simulates the natural curvature of the eyelid over the eyeball to investigate the friction mechanisms underlying blink-related discomfort du...
Nr2e3-Deficient Mice Show Evidence for Elevated Photoreceptor Bioenergetics and Retinal Visual Cycle Activity Based on OCT Metabolic Biomarkers [0.03%]
Bruce Berkowitz,Robert H Podolsky,Tom Burgoyne et al.
Bruce Berkowitz et al.
Purpose: Ex vivo studies show that photoreceptors of Nr2e3-deficient (rd7) mice display (1) cone-like juxtanuclear mitochondria suggesting higher bioenergetics than in wild-type (WT) mice, and (2) reliance on a cone-only ...
PCYT1A Hypophosphorylation Underlies Retinal Lipid Dysregulation in CERKL Retinitis Pigmentosa and Is Therapeutically Reversed by Phosphatidylcholine [0.03%]
Pan Gao,Pei Li,Yayun Qin et al.
Pan Gao et al.
Purpose: Retinitis pigmentosa (RP) is one of the main causes of hereditary blindness, and its genetic mode shows high heterogeneity. Among them, the mutation of the CERKL gene has been identified as the causative gene rel...
Early Functional Biomarkers of Idiopathic Epiretinal Membrane Progression: A 24-Month Prospective Observational Study [0.03%]
Paola Marolo,Xuenan Zhuang,Enrico Borrelli et al.
Paola Marolo et al.
Purpose: To identify early functional biomarkers of progression in idiopathic epiretinal membrane (iERM) eyes managed conservatively, with particular emphasis on near-vision performance. ...
Observational Study
Investigative ophthalmology & visual science. 2026 Apr 1;67(4):55. DOI:10.1167/iovs.67.4.55 2026
Genetic Architecture of Trans-Laminar Cribrosa Pressure Difference and Primary Open-Angle Glaucoma [0.03%]
In-Shik Hong,Chamlee Cho,Beomsu Kim et al.
In-Shik Hong et al.
Purpose: The purpose of this study was to investigate whether the genetic architecture of translaminar cribrosa pressure difference (TLCPD) provides genetic insights based on dual-pressure theory beyond intraocular pressu...
Cross-Cohort Evidence of Editome Dysregulation and Cell Growth-Related IGFBP7 Recoding Driven by ADARB1 in Fuchs Endothelial Corneal Dystrophy [0.03%]
Kai-Tong Yang,Jia-Qi Pan,Yun-Yun Jin et al.
Kai-Tong Yang et al.
Purpose: Fuchs endothelial corneal dystrophy (FECD) is a degenerative disease characterized by progressive loss of corneal endothelial cells, yet the role of adenosine-to-inosine (A-to-I) RNA editing mediated by adenosine...
Rod Pathway Dysfunction in Early-Stage Diabetic Retinopathy Assessed by ERG and Pupillometry [0.03%]
Jason C Park,Andrew Cross,J Jason McAnany
Jason C Park
Purpose: To provide insight into rod pathway dysfunction in early-stage diabetic retinopathy (DR) by measuring dark-adapted ERGs and pupillary light reflexes (PLRs) across a broad range of stimulus luminance. ...
Mean Apparent Propagator MRI: A Potential Imaging Biomarker of Brain Microstructural Alterations in Basic-Type Intermittent Exotropia [0.03%]
Qinglei Shi,Mengdi Zhou,Diwei Shi et al.
Qinglei Shi et al.
Purpose: This study aimed to investigate brain microstructural alterations in children with basic-type intermittent exotropia (IXT) using mean apparent propagator magnetic resonance imaging (MAP-MRI) and to analyze their ...
TXNDC5 in POAG: Promoting Extracellular Matrix Protein Accumulation and Raising Intraocular Pressure [0.03%]
Dan Song,Lixin Wen,Mingmin Hou et al.
Dan Song et al.
Purpose: Excessive accumulation of extracellular matrix (ECM) proteins in the trabecular meshwork (TM) leads to increased resistance to outflow of aqueous humor (AH) and the consequent increase in intraocular pressure (IO...
Safety and Efficacy of cceAAV-aflibercept-Fc-YTE (F-CRG-B191): A Gene Therapy for Neovascular Age-Related Macular Degeneration [0.03%]
Jiemei Shi,Huan Xu,Hongmei Zhao et al.
Jiemei Shi et al.
Purpose: To evaluate the safety and efficacy of a novel gene therapy vector, covalently closed-end double-stranded adeno-associated virus-aflibercept-Fc-YTE (cceAAV-aflibercept-Fc-YTE; clinical trial name F-CRG-B191), des...