Ezh2 Control of Bivalent Genes Fine-Tunes Developmental Competence During Retinogenesis [0.03%]
Ezh2通过控制基因的二价状态微调视网膜发育过程中的多能性
Emily Davis,Abdullah Khan,Issam Aldiri
Emily Davis
Purpose: Chromatin-based repression is essential for retinal development, yet the genome-wide binding landscape of Polycomb repressive complex 2 (PRC2) in the developing retina has not been defined. In particular, how the...
Chrysin Attenuates Dry Eye Progression by Suppressing NOX2-Dependent Ferroptosis and STING/NLRP3-Mediated Inflammatory Responses [0.03%]
染料木素通过抑制NOX2依赖性铁死亡和STING/NLRP3介导的炎症反应来缓解干眼病的发展
Licheng Li,Haoyu Li,Hanhan Peng et al.
Licheng Li et al.
Purpose: This study aimed to evaluate the effects of chrysin on dry eye and to elucidate its underlying mechanisms. Methods: Public tra...
Complement C5a Promotes Epithelial-Mesenchymal Transition in Pterygium via C5aR Activation [0.03%]
补体C5a通过C5a受体活化促进翼状胬肉上皮间质转化
Jiaxin Han,Qianwen Gong,He Wang et al.
Jiaxin Han et al.
Purpose: The purpose of this study was to investigate candidate regulatory proteins associated with the pathogenesis of pterygium and to explore their potential biological roles. ...
Sex Hormone Imbalance in Keratoconus: Estrogen-Mediated Collagen Remodeling and Biomechanical Weakening [0.03%]
角膜扩张症中的性激素失衡：雌激素介导的胶原蛋白重塑和生物力学削弱
Mengyu Zhang,Yan Liu,Ning Gao et al.
Mengyu Zhang et al.
Purpose: To investigate the role of sex hormone imbalance in keratoconus (KC) pathogenesis and its effects on corneal collagen metabolism and biomechanics. ...
NEDD8 Promotes the Progression and Inflammation of Keratoconus by Increasing the Expression of YAP1 [0.03%]
NEDD8通过增加YAP1表达促进角膜基质锥形变病的进展和炎症反应
Junpeng Qu,Xiaowen Zhang,Chao Wei et al.
Junpeng Qu et al.
Purpose: Keratoconus (KC) is an adolescent-onset vision-impairing corneal disorder with incompletely elucidated pathogenesis. This study aims to elucidate the regulatory role of NEDD8 in the Hippo-YAP signaling pathway an...
Dose-Response Characteristics of Retinal Inactivation Due to Intravitreal Injections of Tetrodotoxin in Nonhuman Primates [0.03%]
四叠体毒素玻璃体内注射诱导食蟹猴视网膜失神经的剂量效应特点研究
Randolph J Kwaw,Kevin R Duffy,Hui Meng et al.
Randolph J Kwaw et al.
Purpose: Temporary retinal inactivation of the fellow eye with intravitreal tetrodotoxin (TTX) has shown promise as a treatment strategy for deprivation amblyopia in mouse and cat models. The purpose of this study was to ...
Short-Term Effects of Optically Induced and Digitally Simulated Myopic Blur on Retinal Perfusion: Insights From Optical Coherence Tomography Angiography [0.03%]
基于光学相干断层扫描血管造影的近视模糊对视网膜灌注短期影响的研究
Hosein Hoseini-Yazdi,Scott A Read,Fan Yi et al.
Hosein Hoseini-Yazdi et al.
Purpose: To examine changes in retinal perfusion density (PD) following short-term exposure to optically induced myopic defocus, an ocular growth-inhibitory stimulus, and achromatic digitally simulated myopic blur, an ocu...
Diosgenin Attenuates Photoreceptor Degeneration in an N-Methyl-N-Nitrosourea-Induced Mouse Model of Retinal Degeneration [0.03%]
薯蓣皂苷元通过下调MCT1介导的天冬氨酸外流抑制N-硝基脲引发视网膜退行性疾病模型中的光受体神经元退化作用研究
Wanqing Tong,Jinfeng Cao,Xuebin Zhou et al.
Wanqing Tong et al.
Purpose: Retinitis pigmentosa (RP) is a hereditary retinal disorder distinguished by progressive photoreceptor cell (PRC) loss, in which glial activation can accelerate degeneration. Diosgenin, a natural steroidal sapogen...
Modulation of Systemic Osmolarity Alters Retinal Thickness and Schisis Cavities Without Blood Retinal Barrier Disruption in Rs1 Knockout Mice [0.03%]
渗透压变化对Rs1基因敲除小鼠视网膜影响的实验研究
In Hwan Cho,Ankur Kumar,Zeljka Smit-McBride et al.
In Hwan Cho et al.
Purpose: The purpose of this study was to determine whether systemic osmolarity modulation through dehydration or hydration alters retinal thickness and schisis cavity area in Rs1 knockout (KO) mice compared with wild-typ...
Stress Responsive bZIP Transcription Factors ATF4 and BACH1 Cooperate With MAF-Family bZIP Protein NRL to Fine-Tune Rod Photoreceptor Gene Expression [0.03%]
应激反应bZIP转录因子ATF4和BACH1与MAF家族bZIP蛋白NRL协作，精细调节杆状光受体基因表达
Kiam Preston Jr,Madhuri Arya,Anjani Kumari et al.
Kiam Preston Jr et al.
Purpose: Musculoaponeurotic fibrosarcoma (MAF) family basic motif leucine zipper (bZIP) transcription factor neural retina leucine zipper (NRL) determines rod cell fate and controls expression of rod genes in concert with...