Central Bouquet Hemorrhages in Retinal Vein Occlusion: A Distinct Pathway to Macular Atrophy [0.03%]
视网膜静脉阻塞中央花束出血致黄斑萎缩的特异途径
Maria Vittoria Cicinelli,Enrico Maria Pepe,Prithvi Ramtohul et al.
Maria Vittoria Cicinelli et al.
Purpose: To characterize central bouquet hemorrhages (CBHs) in retinal vein occlusion (RVO) and evaluate their association with long-term visual and anatomical outcomes, in particular macular atrophy. This is a retrospect...
Targeting Bcl3/NF-κB p50 Pathway for Neuroinflammation Attenuation and RGCs Protection in Retinal Ischemia/Reperfusion Injury [0.03%]
靶向Bcl3/NF-κB p50信号通路减轻视网膜缺血再灌注损伤中的神经炎症和视网膜神经节细胞保护作用
Meini Chen,Xuan Zhang,Zhou Zeng et al.
Meini Chen et al.
Purpose: Retinal ischemia/reperfusion (IR) injury caused by pathologically high intraocular pressure (ph-IOP) induces excessive inflammation, contributing to retinal ganglion cell (RGC) death in glaucoma. Lowering IOP alo...
Association Between Ocular Microbiomes of Children and Their Siblings and Parents [0.03%]
儿童及其兄弟姐妹和父母的微生物组关联研究
Xiangtian Ling,Yuzhou Zhang,Christine H T Bui et al.
Xiangtian Ling et al.
Purpose: This study aims to investigate the association of ocular microbiomes between children and their parents and siblings. Methods: ...
Observational Study
Investigative ophthalmology & visual science. 2025 Sep 2;66(12):59. DOI:10.1167/iovs.66.12.59 2025
Enabling In Vivo Longitudinal Evaluation of Descemet's Membrane Thickness in Wild-type and FECD Mice Using Self-Referenced Optical Coherence Microscopy [0.03%]
基于自参考的光相干显微镜在野生型和FECD小鼠活体角膜内皮长期观测中的应用研究
Hadiya Farhath Pattan,Subashree Murugan,Rajalekshmy Shyam et al.
Hadiya Farhath Pattan et al.
Purpose: Descemet's membrane (DM) remodeling is a key factor in the etiology of early-onset Fuchs endothelial corneal dystrophy (FECD). Although various mouse models have been developed to replicate major FECD phenotypes,...
Establishment of an Advanced In Vitro Model for Pseudoexfoliation Syndrome and Glaucoma [0.03%]
伪絨毛膜综合征和青光眼的先进体外模型建立
Sai Pulasani,Matthias Zenkel,Robert Lämmer et al.
Sai Pulasani et al.
Purpose: Pseudoexfoliation (PEX) glaucoma is caused by progressive accumulation of abnormal fibrillar aggregates in aqueous humor outflow tissues. The current lack of effective models for PEX research, replicating the key...
Topical Application of Everolimus Attenuates Lens-Induced Myopia Through mTORC1 Suppression [0.03%]
topical application of everolimus通过抑制mTORC1缓解 lenses诱导的近视
Ruiheng Zhang,Chuyao Yu,Yitong Li et al.
Ruiheng Zhang et al.
Purpose: The mechanistic target of rapamycin complex 1 (mTORC1) signaling has been reported to regulate lens-induced myopia (LIM) in guinea pigs. To address the challenge of delivering lipophilic mTORC1 inhibitors to the ...
Evaluating the Optic Nerve Crush Model to Understand the Function of Microglia in Glaucoma Neuroprotection [0.03%]
评估视神经压榨模型以了解小胶质细胞在青光眼神经保护中的作用
Xiaowu Gu,Tom Truong,Tiffany Heaster-Ford et al.
Xiaowu Gu et al.
Purpose: Microgliosis is a key neuroinflammatory feature in human glaucomatous retinas, believed to contribute to disease progression. This study aims to characterize changes in microglia and intra-retinal axons following...
Characterizing Long-Chain 3-Hydroxy-Acyl-CoA Dehydrogenase Deficiency (LCHADD) Chorioretinopathy Using OCT and OCTA [0.03%]
应用OCT和OCTA表征长链3-羟基酰基辅酶A脱氢酶缺乏症(LCHADD)视网膜病变
Xiaohui Hua,Tristan T Hormel,Jie Wang et al.
Xiaohui Hua et al.
Purpose: To characterize structural and microvascular alterations in chorioretinopathy in patients with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD) using optical coherence tomography (OCT) and OCT angio...
Hydrogen Sulfide-Preconditioned Mesenchymal Stem Cells Attenuate Ferroptosis in Corneal Alkali Burn via the AMPK/Nrf2/HO-1 Pathway in an IL-10-Dependent Manner [0.03%]
氢硫化物预处理的间充质干细胞通过AMPK/Nrf2/HO-1通路依赖IL-10的方式缓解碱烧伤角膜铁死亡的研究
Mingxiong Chen,Yilin Jiang,Hanrui Yu et al.
Mingxiong Chen et al.
Purpose: We aimed to investigate whether hydrogen sulfide (H2S)-preconditioned mesenchymal stem cells (MSCs) could enhance the anti-ferroptotic effects in a murine model of corneal alkali burn. ...
Predicting the Effects of Customized Corneal Cross-Linking on Corneal Geometry [0.03%]
预测个性化角膜交联对角膜几何形态的影响
Matteo Frigelli,Miguel A Ariza Gracia,M Enes Aydemir et al.
Matteo Frigelli et al.
Purpose: To validate an existing finite element model (FEM) for predicting the flattening effect of corneal cross-linking (CXL) in a clinical scenario and to use this model to investigate the parameters that most influenc...