Akinori Miyashita,Ai Obinata,Norikazu Hara et al.
Akinori Miyashita et al.
Background: APOE is a major susceptibility gene for Alzheimer's disease (AD). Recent studies conducted in Europe and the United States have identified rare missense variants (RMVs) in APOE that are significantly associate...
Vincent Doyon,Félix Janelle,Samantha Côté et al.
Vincent Doyon et al.
Background: While several lines of evidence suggest that pathological tau propagates in the brain in a prion-like manner via the synapses, little is known about the reason for its initial appearance in the medial temporal...
Adejoke Elizabeth Memudu,Peace Oluwabunmi Popoola,Amadi Ogonda Ihunwo et al.
Adejoke Elizabeth Memudu et al.
Background: Ethnopharmacology of plant based dietary compounds with antioxidant activity such as lutein-20, needs to be evaluated in animal model of Alzheimer's disease (AD) to assess the antioxidant and inflammatory inde...
Jennifer A Smith,Hasan Abu-Amara,Wei Zhao et al.
Jennifer A Smith et al.
Background: Alzheimer's disease (AD) and related dementias are a growing health and economic burden in India, the most populous country in the world. Blood levels of amyloid beta (Aß), tau, and other proteins marking neu...
Liang Ma
Liang Ma
Background: The APOE gene is the strongest genetic risk factor for late-onset Alzheimer's Disease (LOAD). However, the gene regulatory mechanisms at this locus remain incompletely characterized. ...
Miranda E Orr
Miranda E Orr
Background: The microtubule-associated protein tau undergoes reversible post-translational modifications in response to various stress conditions, preserving neuronal function and stability. However, under sustained stres...
Fangda Leng,Yang Zhiyuan,Paul Edison et al.
Fangda Leng et al.
Background: Accumulating evidence demonstrated the trans-regional propagation behaviour of Alzheimer's pathology across brain. Spatial patterns of amyloid and Tau pathology emergence have also been established. However, t...
Noah Cook,Chenyu Yang,Danielle M Reid et al.
Noah Cook et al.
Background: Our group recently performed the largest-to-date X-chromosome wide association study (XWAS) of Alzheimer's disease (AD). Here, we expand on this with additional samples, novel sex- and APOE*4-stratified analys...
Kate Noseworthy,Joseph Silburt,Laura M Vecchio et al.
Kate Noseworthy et al.
Background: Treatments for supporting oligodendrocytes and restoring myelin in Alzheimer disease (AD) are limited. Focused ultrasound (FUS) with microbubbles (MB) increases the permeability of the blood-brain-barrier (BBB...
Public Health [0.03%]
公共卫生
Rachel Peterson,Pauline Maillard,Nancy X Chen et al.
Rachel Peterson et al.
Background: Adulthood socioeconomic status (SES) is associated with better late-life brain health but links with lifecourse SES are unclear. Method: ...