Neurobiological markers across joint profiles of subjective cognitive decline and objective cognitive function in older adults [0.03%]
老年人认知功能客观指标和主观判断下降的联合谱系中的神经生物学标志物
Lu Wan,Chaeryon Kang,Rae Harrison et al.
Lu Wan et al.
Introduction: Subjective cognitive concerns frequently diverge from objective cognitive performance in cognitively unimpaired (CU) older adults, yet the neurobiological basis of this mismatch remains unclear. ...
Alexander J Ehrenberg,Neus Falgàs,Heidi I L Jacobs et al.
Alexander J Ehrenberg et al.
APOE and genetic risk variants influence Alzheimer's disease onset in carriers of an extra copy of APP, with and without Down syndrome [0.03%]
APOE和遗传风险变异体影响APP多拷贝伴随或不伴唐氏综合征的阿尔茨海默病发病年龄
Joan Groeneveld,Danna Perlaza,Clàudia Olivé et al.
Joan Groeneveld et al.
Introduction: An extra copy of the amyloid precursor protein (APP) gene causes autosomal dominant Alzheimer's disease (AD) and AD in Down syndrome (DS), but the factors underlying variability in age at onset (AAO) remain ...
miR155, triplicated in Down syndrome, regulates the development of neural stem cells and GABAergic interneurons in Alzheimer's disease mouse and human iPSC models [0.03%]
与唐氏综合征三体序列相关的 miR155通过调控神经干细胞和GABA能中间神经元的发育促进阿尔茨海默病发生发展
Xiaodong Zhu,Jean-Vianney Haure-Mirande,Mesude Bicak et al.
Xiaodong Zhu et al.
Introduction: Dysfunctional microRNAs and GABAergic interneurons are features of Alzheimer's disease (AD). The role of neuronal microRNA155 (miR155), elevated in both AD and Down syndrome (DS), remains unknown. ...
The past, the present, and the future of preclinical mouse models for Alzheimer's disease and related dementias [0.03%]
阿尔茨海默病及相关痴呆症的前临床小鼠模型的过去、现在和未来
Adrian L Oblak,Michael Sasner,Gregory W Carter et al.
Adrian L Oblak et al.
Over the past decade, the Model Organism Development and Evaluation for Late-Onset Alzheimer's Disease (MODEL-AD) consortium has transformed preclinical Alzheimer's disease (AD) research by addressing critical limitations in traditional mou...
Plasma P-tau217 for detecting amyloid clearance after donanemab in Alzheimer's disease [0.03%]
血浆P-tau217检测淀粉样蛋白清除在阿尔茨海默病中的作用——DONANEMAB试验的探索性分析
Emily C Collins,Ming Lu,Rose Beck et al.
Emily C Collins et al.
Introduction: This analysis of the phase 3 TRAILBLAZER-ALZ 2 trial examined whether plasma tau protein phosphorylated at threonine 217 (p-tau217) level can reliably monitor treatment-related amyloid clearance (TRAC) after...
Randomized Controlled Trial
Alzheimer's & dementia : the journal of the Alzheimer's Association. 2026 Aug;22(8):e71740. DOI:10.1002/alz.71740 2026
Hormone replacement therapy and its association with LATE-NC in older adults [0.03%]
激素替代疗法与老年人晚期神经认知障碍的关系
Yohana M Kim,Katherine Colcord,S Ahmad Sajjadi et al.
Yohana M Kim et al.
Introduction: Limbic-predominant age-related transactive response DNA-binding protein 43 (TDP-43) encephalopathy neuropathological change (LATE-NC) is a cause of dementia resembling Alzheimer's disease (AD). The 90+ Study...
Dorsal raphe tau pathology disrupts sleep-wake orchestration and sleep architecture in a sex-specific manner [0.03%]
背缝核tau病变以性别特异性的方式破坏清醒睡眠协调和睡眠结构
Louis J Kolling,Ruixiang Wang,Gabriel S Gaudencio et al.
Louis J Kolling et al.
Introduction: Sleep disturbances are frequent symptoms of Alzheimer's disease (AD), mirrored by early pathology in the dorsal raphe nucleus (DRN). Whether early DRN pathology can drive sleep disturbances, and the relative...
A randomized phase 1b/2 trial of ABBV-916 in adults with early Alzheimer's disease [0.03%]
ABBV-916治疗轻度阿尔茨海默病的1b/2期临床试验
Shau Yu Lynch,Yamin Wang,Deli Wang et al.
Shau Yu Lynch et al.
Introduction: ABBV-916, an anti-amyloid immunotherapy, was evaluated in patients with early Alzheimer's disease (AD). Methods: This pha...
Temporalis muscle biomarkers from routine brain MRI and risk of dementia in two independent cohorts [0.03%]
基于常规脑MRI的颞肌生物标志物与两个独立队列的认知障碍风险的关系
Kamyar Moradi,Roham Hadidchi,Amyn Majbri et al.
Kamyar Moradi et al.
Introduction: Skeletal muscle loss is associated with cognitive decline, but whether neuroimaging-derived muscle characteristics predict incident dementia remains unclear. ...