Hayley R C Shanks,Sherry Chen,Kate M Onuska et al.
Hayley R C Shanks et al.
The cholinergic neurons of the basal forebrain are among the most vulnerable cell types to age- and Alzheimer's disease-related dysfunction and neurodegeneration. However, the biological bases of basal forebrain cholinergic vulnerability (t...
Five-year change in brain metabolism across the spectrum of cognitive impairment in older adults: a quantitative MRI study [0.03%]
老年人认知障碍谱系五年来脑代谢变化的研究：一项定量磁共振研究
Jiani Wu,Kumiko Oishi,Anja Soldan et al.
Jiani Wu et al.
Introduction: It is desirable to measure brain metabolism without needing ionizing radiation and elucidate its time trajectory. This study employed a positron emission tomography -validated, non-invasive magnetic resonanc...
"Digital eye tracking and plasma biomarkers: Distinguishing functional cognitive impairment from Alzheimer's disease biology" [0.03%]
数字眼动检测和血浆生物标志物：区分功能性认知障碍与阿尔茨海默病生物学特征
Yi Ling,Pan Sun,Tengfei Guo et al.
Yi Ling et al.
Digital eye tracking and plasma biomarkers: Distinguishing functional cognitive impairment from Alzheimer's disease biology [0.03%]
数字眼动检测和血浆生物标志物：功能性认知障碍与阿尔茨海默病生物学的区别
Julián Benito-León,Carla María Benito-Rodríguez
Julián Benito-León
Endogenously generated Dutch-type Aβ non-fibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation [0.03%]
内源性产生的荷兰型Aβ非原纤维聚集物在没有可检测到的炎症的情况下干扰突触前神经传递
Emilie L Castranio,Merina Varghese,Elentina K Argyrousi et al.
Emilie L Castranio et al.
Background: APPE693Q ("Dutch") transgenic mice develop aging-related learning deficits and accumulate endogenously generated non-fibrillar aggregates (NFAs) of amyloid beta (Aβ) and amyloid precursor protein α-carboxy t...
Urban greenspace and dementia: Measures, mechanisms, and methodological guidance [0.03%]
城市绿地与痴呆症：措施、机制和方法论指导
Ingrid Jarvis,Lilah Besser,Jessica Finlay et al.
Ingrid Jarvis et al.
Urban greenspace has been associated with improved cognition and reduced Alzheimer's disease (AD) and AD-related dementias (ADRD) risk, but findings remain mixed, study quality varies, and evidence is largely cross-sectional. To advance the...
Stable neuronal representations underlie cognitive resilience to Alzheimer's disease pathology [0.03%]
稳定的神经元表示是阿尔茨海默病病理条件下认知弹性的基础
Keying Chen,Emma Pineau,Margaret Koletar et al.
Keying Chen et al.
Introduction: While Alzheimer's disease (AD) typically elicits progressive cognitive decline, some individuals with significant AD pathology maintain cognition. Understanding the neuronal underpinnings of such cognitive r...
Early microglial response to amyloid plaques drives sleep loss in Alzheimer's disease [0.03%]
阿尔茨海默病中微胶质细胞对淀粉样蛋白斑块的早期反应导致睡眠丧失
Nicholas J Constantino,Riley E Irmen,Matthew J Lanning et al.
Nicholas J Constantino et al.
Introduction: Sleep disruption is an early feature of Alzheimer's disease (AD), but the cellular mechanisms linking amyloid pathology to sleep loss remain unclear. ...
Differential associations of plasma biomarkers with Alzheimer's disease and small vessel disease: A multimodal imaging study [0.03%]
血浆生物标志物与阿尔茨海默病和小血管疾病的关联：一项多模态影像学研究
Anna Dewenter,Katharina Bürger,Daniel Janowitz et al.
Anna Dewenter et al.
Introduction: We investigated how plasma biomarkers (phosphorylated tau 217 [ptau217], glial fibrillary acidic protein [GFAP], neurofilament light chain [NfL]) relate to imaging markers of small vessel disease (SVD) and A...
Mapping cross-domain drivers of Alzheimer's disease risk through integrated network analysis [0.03%]
通过综合网络分析绘制阿尔茨海默病风险的跨域驱动因素地图
Gregory A Cary,Stephen Keegan,Jesse C Wiley et al.
Gregory A Cary et al.
Introduction: Alzheimer's disease (AD) is a complex neurodegenerative disorder with numerous known risk factors. Identification of which genetic factors are causal drivers is difficult due to the long disease prodrome in ...