An automated plasma-based proteotyping immunoassay for APOE ε4 zygosity classification in Alzheimer's disease [0.03%]
阿尔茨海默病中APOE ε4杂合子分类的自动化等离子体基质辅助免疫测定法
Scott Levin,Brian Engel,Corey Carlson et al.
Scott Levin et al.
Introduction: Determining apolipoprotein E (APOE) ε4 allele status, a key genetic risk factor for Alzheimer's disease (AD), requires molecular genotyping infrastructure not widely accessible beyond specialized centers. ...
In vivo mapping of cortical amyloid beta-myelin coupling in preclinical Alzheimer's disease [0.03%]
阿尔茨海默病前临床期皮层amyloid β-髓鞘耦合的体内定位研究
Mercedes Atienza,Jose L Cantero
Mercedes Atienza
Introduction: Accumulating evidence suggests that amyloid-β (Aβ) preferentially deposits in poorly myelinated cortical regions and may interfere with remyelination. We hypothesized that this vulnerability would manifest...
The relationships between ethnoracial identity, Aβ positivity, APOEε4, and medial temporal lobe tau PET [0.03%]
种族身份、Aβ阳性、APOE ε4与中颞叶tau-PET之间的关系
Koral V Wheeler,Victoria R Tennant,Noelle N Lee et al.
Koral V Wheeler et al.
Introduction: Clarifying relationships between amyloid, tau, and cognition is crucial to understanding dementia risk, but has been mainly performed in non-Hispanic White (NHW) participants. It is unknown whether findings ...
The sex-specific association between long-term PM2.5 exposure and incident dementia in community-dwelling older adults in Australia [0.03%]
澳大利亚社区居住老年人长期暴露于细颗粒物与性别的痴呆症发病率之间的关联研究
Aoshuang Zhou,Zhen Zhou,Wenhua Yu et al.
Aoshuang Zhou et al.
Introduction: Air pollution is linked to dementia, but evidence from low-exposure settings is limited. We examined sex-specific associations between long-term exposure to fine particulate matter ≤2.5 µm in diameter (PM2...
A cross-consortium, stakeholder-driven model for implementing a modern electronic data capture and submission system across the Alzheimer's Disease Research Centers Program [0.03%]
美国阿尔茨海默病研究计划中实施现代电子数据采集和提交系统的一种跨财团、利益相关者驱动的模型
Sarah Biber,Sarah Gothard,Charles F Murchison et al.
Sarah Biber et al.
Introduction: The National Alzheimer's Coordinating Center (NACC) and Alzheimer's Disease Research Center (ADRC) Program advances dementia research by collecting and sharing standardized, longitudinal data, including the ...
The spleen-brain axis in Alzheimer's disease and related dementias: Integrating immune and metabolic regulation [0.03%]
阿尔茨海默病和相关痴呆症中的脾-脑轴：整合免疫和代谢调节
Jingsi Yan,Jiayu Zhang,Xinyi Ye et al.
Jingsi Yan et al.
Emerging evidence highlights the central role of peripheral immune-metabolic regulation in the pathogenesis of Alzheimer's disease and related dementias (ADRD). Among peripheral organs, the spleen has gained increasing attention as a critic...
Cognitive screening biases in a secondary prevention Alzheimer's disease clinical trial [0.03%]
二级预防阿尔茨海默病临床试验中的认知筛查偏差
Isha Sai,Joshua D Grill,Kyan Younes et al.
Isha Sai et al.
Introduction: Alzheimer's disease (AD) prevention trials have multiple steps to identify cognitively unimpaired individuals with AD biomarker evidence. Cognitive/functional screening tests may be biased in ethnoracial min...
Jennifer A Frontera,Arjun V Masurkar,Rebecca A Betensky et al.
Jennifer A Frontera et al.
Introduction: Though brain fog is common in Long-coronavirus disease 2019 (Long-COVID), the incidence of mild cognitive impairment (MCI) is unknown. Metho...
Altered locus coeruleus links to atrophy and hypometabolism in individuals with high Alzheimer's disease biomarkers [0.03%]
改变的蓝斑核与高阿尔茨海默病生物标志物个体的脑萎缩和低代谢有关
Emilie Foyard,Tao Blanchard,Brigitte Landeau et al.
Emilie Foyard et al.
Introduction: The locus coeruleus (LC), the first region to contain tau pathology in Alzheimer's disease (AD), releases norepinephrine, which has a neuroprotective role. We examined whether LC integrity relates to whole-b...
Randomized Controlled Trial
Alzheimer's & dementia : the journal of the Alzheimer's Association. 2026 Mar;22(3):e71212. DOI:10.1002/alz.71212 2026
Implication of the thalamus in sleep alterations observed in Alzheimer's disease [0.03%]
丘脑在阿尔茨海默病中观察到的睡眠改变中的作用
Carla Burnet-Merlin,Y Audrey Hay,Aurélie Brécier
Carla Burnet-Merlin
Alzheimer's disease (AD), the most common neurodegenerative disorder, is frequently accompanied by sleep disturbances. Alterations of sleep, in both quality and quantity, contribute to the progression of AD neuropathology. The thalamus, thr...