Sarah Bellaflor,Ahmad Mohammad,Rebecca Ek MacPherson
Sarah Bellaflor
Background: Amyloidogenic processing of the transmembrane protein amyloid precursor protein (APP), by BACE1, results in the production of Aβ peptides which are a pathological hallmark of Alzheimer's disease (AD). AD is a...
Niels Reijner,Danielle V Toen,Betty M Tijms et al.
Niels Reijner et al.
Background: Microstructural changes precede Alzheimer's-related brain atrophy and cognitive decline by years, and persist throughout disease progression, making their detection crucial. The T1-weighted/T2-weighted MR imag...
Zezong Gu,Marcus Jackson,Tamanna Mony et al.
Zezong Gu et al.
Background: Traumatic brain injury (TBI) accelerates risk for multiple Alzheimer's Disease and Related Dementias (ADRDs) featuring Tau protein hyperphosphorylation and tauopathy. Mild TBI (mTBI) causes a temporary disrupt...
Anssi Lipponen,Sami Heikkinen,Joel Räsänen et al.
Anssi Lipponen et al.
Background: In idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's disease (AD), clearance of cerebrospinal fluid (CSF) is impaired, leading to the buildup of harmful proteins and metabolic waste in the brain,...
Valentina Perosa,Menab Said
Valentina Perosa
Background: Quantitative susceptibility mapping(QSM) is a MRI processing technique that relies on gradient-echo sequences to quantify the magnetic susceptibility of the brain tissue. QSM has been associated to leakage of ...
Danielle Cozachenco,Ricardo A S Lima-Filho,Mariana Chauvet et al.
Danielle Cozachenco et al.
Background: The major histopathological hallmarks of Alzheimer's disease (AD) are neurofibrillary tangles, composed of the tau protein, and fibrillar aggregates of Aβ peptide. Considerable evidence points to important ro...
James Eric Carmichael,Martha Liu,TianMeng Xu et al.
James Eric Carmichael et al.
Background: Among the earliest signs of preclinical Alzheimer's disease (AD) are navigation impairments and the presence of abnormal hyperphosphorylated tau (aTau) proteins in the entorhinal cortex (EC), a brain region th...
Margaret M Tish,Lauren Gao,Zihui Ou et al.
Margaret M Tish et al.
Background: The locus coeruleus (LC), is the first brain region to develop hyperphosphorylated tau (ptau) inclusions in Alzheimer's disease (AD) and undergoes catastrophic degeneration in later disease stages. Importantly...
Lauren Bass,Amanda Kuzma,Otto Valladares et al.
Lauren Bass et al.
Background: NIAGADS is a national genomics data repository that facilitates access of genotypic and sequencing data to qualified investigators for the study of the genetics of Alzheimer's disease (AD) and related neurolog...
Jiali Li
Jiali Li
Background: Alzheimer's disease (AD) is a major contributor to neuropsychiatric disorders, exerting profound impacts on individuals and society. Social behavioral impairments associated with AD present significant challen...