Madison R Longmuir
Madison R Longmuir
Background: ApoE4 is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Compared to ApoE4 noncarriers (ApoE4-), ApoE4 carriers (ApoE4+) exhibit earlier onset and more rapid progression of memory im...
Elliot Keats Shwab,Daniel Gingerich,Dellila Hodgson et al.
Elliot Keats Shwab et al.
Background: The multifactorial and heterogenous nature of Late Onset Alzheimer's disease (LOAD) presents a challenge, particularly in capturing genetic complexity across diverse populations. Recent single-nucleus (sn)mult...
Amy Christensen,Cassandra J McGill,Ali Zaidi et al.
Amy Christensen et al.
Background: The greatest risk factor for Alzheimer's disease (AD) is aging. The e4 allele of apolipoprotein E (APOE4) is the primary genetic risk factor for AD and is associated with decreased longevity in both humans and...
Núria Tort-Colet
Núria Tort-Colet
Background: Many Alzheimer's disease (AD) patients experience sleep disturbances and slow wave activity (SWA) alterations have been linked to tau and amyloid (A) β pathology, possibly through glymphatic system (GS) distu...
Marla A Frick,Jennifer L Woodruff,Yair M Caudillo et al.
Marla A Frick et al.
Background: The basal forebrain cholinergic hypothesis (BFCS) describes the degeneration of cholinergic neurons in Alzheimer's Disease (AD) that is correlated with disease pathology and severity [1]. There has been limite...
Eun Hye Lee,Taeho Jo
Eun Hye Lee
Background: The importance of early prediction of Alzheimer's disease (AD) is emerging, and a genomic approach provides a promising path to this goal. One limitation is the high dimensionality of genomic data, which remai...
Sarah Kaufman,Jannis Bücking,Rudra Bose et al.
Sarah Kaufman et al.
Background: Tauopathies including Alzheimer's disease (AD) and progressive supranuclear palsy (PSP) are characterized by the accumulation of aggregated tau protein in selectively vulnerable cell types that are lost in the...
Lisi Flores Aguilar,Sierra Wright,Jillian V Berry et al.
Lisi Flores Aguilar et al.
Background: Individuals with Down syndrome (DS) are at increased genetic risk of developing Alzheimer's disease (AD). By the age of 40 years, most individuals with DS exhibit AD neuropathology, and dementia in their early...
Alexandre Pelletier,Lu Qian,Tony Tuck et al.
Alexandre Pelletier et al.
Background: The allele e4 of the apolipoprotein E gene (APOE4), present in around 20% of the population, is the leading genetic risk factor of late-onset Alzheimer's disease (AD), with APOE4 homozygote (APOE 44) having mo...
Antonio Rocco Fusciardi,Jonathan Mill,Akshay Bhinge
Antonio Rocco Fusciardi
Background: APOE4 is one of the strongest genetic risk factors for developing Alzheimer's disease. Additionally in 80% of severe cases of Alzheimer's disease, TDP43 inclusions have been found in post mortem brain slices, ...