Lovesha Sivanantharajah,Yelena Ivanova,Amritpal Mudher et al.
Lovesha Sivanantharajah et al.
Background: A key feature of tauopathies, including Alzheimer's Disease (AD), is progressive deterioration of neuronal subsets within specific brain regions. One explanation for regional preference is selective vulnerabil...
Xiaoli Hao,Xuewen Xiao,Ling Weng et al.
Xiaoli Hao et al.
Background: Genetic investigations and association with plasma biomarkers of dementia with Lewy bodies (DLB) in East Asian populations are lacking. Method...
Matthew Thomas Bright,Van Dien Nguyen,Bryan Paul Morgan et al.
Matthew Thomas Bright et al.
Background: Complement contributes significantly to pathophysiology in many neurodegenerative diseases (NDDs) including Alzheimer's Disease (AD); yet, the source of complement in the brain is poorly understood. Even multi...
Junyin Lu,Ling Xiao,Xuewen Xiao et al.
Junyin Lu et al.
Background: AD is a neurodegenerative condition characterized by progressive neuronal loss and the abnormal deposition of Aβ proteins. To date, the in vivo Aβ deposition measured by 11C-PIB PET and the underlying gene e...
Lance A Johnson
Lance A Johnson
Background: Compared to individuals carrying two copies of the E4 allele of Apolipoprotein E (APOE), E2 homozygotes have a ∼99% reduction in late-onset Alzheimer's disease (AD) risk. Given its strong risk profile and mul...
Yifei Cai,Iguaracy Pinheiro-de-Sousa,Mykhaylo Slobodyanyuk et al.
Yifei Cai et al.
Background: Myelin ensheathment is essential for rapid axonal electrical conduction, metabolic support and neuronal plasticity. In Alzheimer's disease (AD), disruptions in both myelin and axonal structures occur; however,...
Hyun Woong Roh,Sunwoo Yoon,Homin Song et al.
Hyun Woong Roh et al.
Background: Alterations in circadian rhythms are widely observed in Alzheimer's disease (AD) and other neurodegenerative disorders. However, the significance of ex-vivo cellular circadian periods and their deviation from ...
Benney Mr Argue,David Gate
Benney Mr Argue
Background: Single-cell long-read sequencing was performed on immune cells from cerebrospinal fluid (CSF) and blood to assess isoform diversity in healthy aging individuals and those diagnosed with mild cognitive impairme...
Gabriel E Hoffman
Gabriel E Hoffman
Background: Genetic risk variants for common diseases are predominantly located in non-coding regulatory regions and modulate gene expression. Although bulk tissue studies have elucidated shared mechanisms of regulatory a...
Inez K A Pranoto,Katherine W Hui,Tiara A Schwarze-Taufiq et al.
Inez K A Pranoto et al.
Background: Anticholinergic medications remain commonly prescribed to older adults, despite mounting evidence linking them to increased dementia risk. Pharmacoepidemiology studies from various populations, including the A...