Bonnie H Lee,Andrew J McGovern,Stephanie E Lieblich et al.
Bonnie H Lee et al.
Background: Females have a higher lifetime risk of Alzheimer's disease (AD) and show greater neuropathology and cognitive decline than males. Furthermore, possession of APOEε4 alleles confers greater risk and burden of A...
Mariane Cristine Vicente,Arthur Dalmolin Dahmer,Kênia Cardoso Bícego et al.
Mariane Cristine Vicente et al.
Background: The literature to oxidative stress as a key contributor to neurodegeneration and neuroinflammation in Alzheimer's disease (AD). Consequently, antioxidant therapies can have a lasting impact for improving the q...
Maria Clara Zanellati
Maria Clara Zanellati
Background: Dysfunctional organelle communication networks are a common hallmark of various neurodegenerative diseases, including Alzheimer's disease (AD). Imaging organelles and their interactions in iPSC-derived neurons...
Matthew J Rosene,Abraham Lopez,Adeeb Ahmad et al.
Matthew J Rosene et al.
Background: DNAJC5 encodes for cysteine string protein-α (CSPα), an endolysosomal cochaperone that regulates synaptic integrity, the exocytosis of neurodegenerative-associated aggregate-prone proteins, and the autophagy...
Hidetomo Tanaka,Lauren E Black,Shelley L Forrest et al.
Hidetomo Tanaka et al.
Background: Tau pathology in the brain associated with chronic traumatic encephalopathy (CTE) is well established, but details regarding protein pathology in the spinal cord remain unclear. Furthermore, CTE is frequently ...
Tallinn Splinter,Madeline Wood Alexander,Amy Kirkham et al.
Tallinn Splinter et al.
Background: There are many menopauses, all marking a significant endocrine transition characterized by the depletion of ovarian hormones, including estradiol and progesterone. This transition, especially when it occurs ea...
Jiemin Yang,Dongyu Wang,Andy Rampersaud et al.
Jiemin Yang et al.
Background: The Alzheimer's Disease Sequencing Project Phenotype Harmonization Consortium (ADSP-PHC) released harmonized longitudinal cognition data across 12 studies enabling genomic analyses of AD related endophenotypes...
Ricardo A S Lima-Filho,Alinny Isaac,Cristovão De Lanna et al.
Ricardo A S Lima-Filho et al.
Background: Ketamine is a non-competitive N-methyl-d-aspartate-type glutamate receptor antagonist mainly used as an anesthetic. In addition to its synaptic effects, ketamine controls signaling pathways linked to mRNA tran...
Adejoke Olukayode Olukayode Obajuluwa,James Chrystopher Lech,Tiwalola Madoc Obajuluwa et al.
Adejoke Olukayode Olukayode Obajuluwa et al.
Background: Excessive nighttime exposure to light-emitting diode (LED) has been implicated in gut-brain axis dysfunction, leading to disrupted serotonin levels that regulate essential functions such as mood, sleep, appeti...
Wei Zhao,Zheng Li,Jennifer A Smith et al.
Wei Zhao et al.
Background: Alzheimer's disease (AD) is characterized by abnormal blood levels of specific proteins associated with amyloid plaques, tau pathology, and neurodegeneration, which are considered biomarkers of AD. To better u...