Carmen Romero Molina,Wen Yi See,Ruben Gomez-Gutierrez et al.
Carmen Romero Molina et al.
Background: The relevance of immunometabolism in AD requires further exploration. Our analysis integrating AD genetics and myeloid cell genomics reported that lower LACTB and LACTB2 expression are protective for AD. LACTB...
Printha Wijesinghe,Jeanne Xi,Matthew Campbell et al.
Printha Wijesinghe et al.
Background: Women are disproportionately affected by Alzheimer's disease (AD), accounting for approximately two-thirds of cases. This disparity arises from multifactorial factors, including greater longevity, hormonal cha...
Kanayo Satoh,Ye Zhou,Roger B Dodd et al.
Kanayo Satoh et al.
Background: The sialic-acid binding immunoglobulin-like lectin 3 receptor (Siglec-3 / CD33) expressed on microglia, regulates immune functions relevant to Alzheimer's disease (AD). Clusterin (CLU) and apolipoprotein E (Ap...
Alvin G Thomas,Laura Raffield,Keenan A Walker et al.
Alvin G Thomas et al.
Background: Older adults may exhibit different levels of cognitive function despite expressing the Alzheimer's disease and related disorders (ADRD) biomarker levels. This observation, attributed to cognitive resilience, o...
Matheus B Victor
Matheus B Victor
Background: Approximately 40% of Alzheimer's disease (AD) patients develop psychotic symptoms (e.g. hallucinations and delusions), yet the neural processes that give rise to neuropsychiatric symptoms in dementia remain po...
Tyler Ard,Michael S Bienkowski,Sook-Lei Liew et al.
Tyler Ard et al.
Background: Alzheimer's research spans multiple disciplines and relies on diverse data types, from brain scans to microscopic images. Traditional scientific publications often struggle to effectively convey this complex i...
Caroline Matos Silva,Alberto Fernando Oliveira Justo,Renata Elaine Paraizo Leite et al.
Caroline Matos Silva et al.
Background: Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is characterized by amnestic dementia, primarily affects adults over 80 and often coexists with other neuropathological l...
Debomoy K Lahiri,Ruizhi Wang,Bryan Maloney et al.
Debomoy K Lahiri et al.
Background: The most common neurodegenerative disorders include Alzheimer's disease (AD), Lewy body and related dementias (ADRDs). Triggers of pathobiochemical changes in ADRDs remains unknown and appear numerous. Short n...
Ester Siantoputri
Ester Siantoputri
Background: The hippocampus, a critical region for learning, memory, and spatial cognition, is affected early in Alzheimer's Disease (AD), while it remains resilient in Huntington's Disease (HD). ...
Madeline Wood Alexander,William G Honer,Rowan Saloner et al.
Madeline Wood Alexander et al.
Background: Early menopause increases Alzheimer's disease (AD) risk in women. Synaptic dysfunction incites and exacerbates AD progression. We investigated whether synergism between age at menopause and synaptic integrity ...