Elinor E Washington,Cathryn A Cutia,Mary E Harrington
Elinor E Washington
Background: Cerebral hypoperfusion occurs when the flow of blood to the brain is decreased, resulting in inadequate blood flow to certain regions of the brain, potentially causing changes in circadian rhythms. The relatio...
Ai Liu
Ai Liu
Background: Alzheimer's disease (AD) affects both grey and white matter, leading to axonal degeneration, demyelination and glial pathologies. This study investigates the impact of pathological hyperphosphorylated tau (p-T...
Cathryn A Cutia,Mary E Harrington
Cathryn A Cutia
Background: Cerebrovascular insufficiency and circadian disruption occur in many Alzheimer's disease (AD) patients. These comorbidities appear in preclinical phases of AD and persist over the progression of the disease. H...
Carlos Wagner Leal Cordeiro Júnior,Luara Bela Rocha Gomes,CaíquePortugal de OliveiraCouto et al.
Carlos Wagner Leal Cordeiro Júnior et al.
Background: Alzheimer's Disease (AD) involves chronic neuroinflammation, exacerbated by the activation of Toll-like receptors (TLRs), such as TLR4, which amplify neurodegeneration through inflammatory cascades. This study...
Anuragh Sriram,Matthew Sadgrove,Gwenn A Garden
Anuragh Sriram
Background: GWAS studies demonstrate an association between the P522R variant of the phospholipase C gamma 2 (PLCG2) gene and a reduced risk for Alzheimer's disease (AD). In the CNS, PLCG2 is a membrane protein specifical...
Ana Tomash,Md Tahmid Yasar,David A A Bennett et al.
Ana Tomash et al.
Background: Brain arteriolosclerosis, characterized by vessel wall thickening and arteriolar narrowing, is a primary pathology of cerebral small vessel disease and is prevalent in older adults. Greater severity is observe...
Grace C George,Sarah A Keller,W Ryan Powell et al.
Grace C George et al.
Background: Alzheimer's Disease and related dementias (ADRD) are complex disorders with increased risk in populations experiencing structural inequities, including those who live in disadvantaged neighborhoods as indexed ...
Roxana O Carare
Roxana O Carare
Background: There are different pathways for the elimination of Cerebrospinal fluid (CSF) from the subarachnoid spaces of adult humans, including drainage across the cribriform plate into the nose. Interstitial fluid is e...
Sungsu Lim,Yun Kyung Kim,Ae Nim Pae
Sungsu Lim
Background: TDP43 proteinopathies, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), are characterized by the pathological aggregation and mislocalization of TDP43 protein. These ...
Luara Bela Rocha Gomes,Carlos Wagner Leal Cordeiro Júnior,Urias Silva Vasconcelos
Luara Bela Rocha Gomes
Background: Osteopontin (SPP1) is a multifunctional glycoprotein that plays a central role in inflammation and tissue remodeling, acting as a critical mediator in the progression of Alzheimer's disease (AD). It interacts ...