Mabel Seto,Hannah M Klinger,Vaibhav A Janve et al.
Mabel Seto et al.
Background: Higher levels of plasma p-tau217 are closely associated with increased Aβ-PET burden, and subsequent cognitive decline in older adults, supporting it as a sensitive, early marker of AD. Previous studies impli...
Maria Capdevila,Laura Guzmán,Marina Carrasco et al.
Maria Capdevila et al.
Background: Extracellular vesicles (EVs) have been described to be involved in the pathogenesis of Alzheimer's disease (AD), but the mechanism remain uncertain. This study aims to examine the AD spreading role of EVs thro...
Yasmine Coovadia,Kathleen B Miller,Nicole A Loggie et al.
Yasmine Coovadia et al.
Background: Blood pressure (BP) dysregulation can significantly disrupt brain circulation, which in turn increases the risk of developing Alzheimer's disease. Both cerebral blood flow (CBF) and BP regulation are influence...
Zichun Xiao
Zichun Xiao
Background: Alzheimer's disease (AD) is a major challenge for the global public health system. AD is the most common (60-70%) type of dementia. Understanding the pathogenesis of AD is vital in developing effective, therap...
Féodora Bertherat,Becky C Carlyle,Nora Bengoa-Vergniory et al.
Féodora Bertherat et al.
Background: This project investigates whether cellular phenotypes observed in iPSC-derived cortical neurons of individual sAD patients can be compared with the clinical measures of the patient they originate from. It also...
Arisa Tamura,Marie Noguchi,Taro Saito et al.
Arisa Tamura et al.
Background: The abnormal accumulation of the microtubule-binding protein tau is a pathological feature in a group of neurodegenerative diseases called tauopathy. Tau accumulation is thought to cause neuronal death, while ...
Holly C Hunsberger,Kameron Kaplan,Lainey B Toennies
Holly C Hunsberger
Background: Our preliminary work revealed earlier anxiety and cognitive decline in female Alzheimer's disease (APP/PS1) mice which correlated to an unbalanced brain-wide network. To validate these preclinical findings, we...
Riham Ayoubi,Aled M Edwards,Peter S McPherson et al.
Riham Ayoubi et al.
Background: Understanding Alzheimer's disease (AD) etiology requires a comprehensive molecular and biological investigation of the estimated 184 genes/proteins linked to AD risk. However, most AD research focuses on 3 gen...
Maya Koronyo-Hamaoui,Jonah Doustar,Yosef Koronyo et al.
Maya Koronyo-Hamaoui et al.
Background: The interplay between vascular dysfunction and brain amyloidosis in driving Alzheimer's disease (AD) pathogenesis and cognitive decline is increasingly recognized. The retina, sharing an embryonic origin with ...
Olga Minaeva,Kevin P Kotredes,Juliet A Moncaster et al.
Olga Minaeva et al.
Background: Age, genetics, and environmental exposure are among the primary risk factors for Alzheimer's Disease (AD) and related dementias (ADRDs) [1]. Exposure to environmental toxicants is disproportionately high in di...