Non-linear associations between sleep duration and plasma p-tau181 in the Framingham Heart Study [0.03%]
弗明汉心脏研究中睡眠时长与血浆p-tau181的非线性关联
Vanessa M Young,Crystal Wiedner,Andrée-Ann Baril et al.
Vanessa M Young et al.
Introduction: Both short and long sleep duration have been associated with Alzheimer's disease (AD) risk, yet the nature of the non-linear associations between sleep quantity and blood-based biomarkers of AD and neurodege...
Changes in arterial stiffness under blood pressure control are independently associated with cognitive impairment: The Systolic Blood Pressure Intervention Trial (SPRINT) [0.03%]
血压控制下动脉僵硬度的变化与认知障碍独立相关：收缩压干预试验(SPRINT)
Timothy M Hughes,Byron C Jaeger,Sarah A Gaussoin et al.
Timothy M Hughes et al.
Background: Effects of blood pressure (BP) control on the relationships between arterial stiffness and subsequent cognitive impairment remain unclear. Met...
Randomized Controlled Trial
Alzheimer's & dementia : the journal of the Alzheimer's Association. 2026 May;22(5):e71444. DOI:10.1002/alz.71444 2026
Sterre C M de Boer,Xulin Liu,Carmela Tartaglia
Sterre C M de Boer
Associations of the Lifestyle for Brain Health (LIBRA) index with cognitive functioning across adulthood: Variation by sex and socioeconomic status in the German National Cohort (NAKO) [0.03%]
用于大脑健康的生括方式（LIBRA）指数与成人认知功能的关系：德国国家队列研究（NAKO）中性别和经济状况的差异
Susanne Röhr,Felix Wittmann,Melanie Luppa et al.
Susanne Röhr et al.
Introduction: The Lifestyle for Brain Health (LIBRA) index evaluates modifiable dementia risk, mainly in midlife and older adults. We examined the frequency of LIBRA factors and their individual and combined associations ...
Elevated AD biomarkers do not explain cognitive performance in a community-recruited clinical trial cohort [0.03%]
在社区招募的临床试验队列中，升高的AD生物标志物无法解释认知表现
Susan M Landau,Peiwei Liu,Theresa M Harrison et al.
Susan M Landau et al.
Introduction: To examine the generalizability of Alzheimer's disease (AD) biomarker models in real-world older adults, we examined AD biomarker relationships with cognition in two multicenter cohorts that differ with resp...
Cognitive dispersion profiles and prediction of cognitive change in early-onset dementias: Results from LEADS [0.03%]
早期发病痴呆的认知弥散模式及其认知变化预测：LEADS研究结果
Dustin B Hammers,Elodie Foster,Ani Eloyan et al.
Dustin B Hammers et al.
Introduction: Research into cognitive dispersion - a cognitive process score measuring the intra-individual variability (IIV) across a single testing session - suggests utility in neurodegenerative populations. Given wide...
G T Sutherland,A Chen,H-T Nguyen-Hao et al.
G T Sutherland et al.
Type 2 diabetes (T2D) and Alzheimer's disease (AD) are both increasing exponentially worldwide. T2D has also been identified as one of 14 modifiable risk factors for dementia, but the mechanism is unknown. T2D could promote dementia via vas...
Neurovascular-metabolic dysregulation, metabolic connectomics, and metabolic functional changes in Alzheimer's disease: A preclinical and clinical comparison [0.03%]
阿尔茨海默病的神经血管代谢失调、代谢连接组学和代谢功能变化：前临床与临床对比研究
Juan Antonio K Chong Chie,Scott A Persohn,Olivia R Simcox et al.
Juan Antonio K Chong Chie et al.
Historically, imaging diagnostics in Alzheimer's disease (AD) have focused primarily on amyloid and tau accumulation; however, recent work suggests that neurometabolic and vascular dysregulation (MVD) may precede protein deposition and pers...
Metabotropic glutamate receptor 5 is associated with plasma GFAP dependent on age [0.03%]
代谢型谷氨酸受体5与年龄依赖性血浆GFAP相关
Tangyue Hu,Yan Wang,Jie Wang et al.
Tangyue Hu et al.
Introduction: We investigated the relationship between metabotropic glutamate receptor subtype 5 (mGluR5) availability and plasma biomarkers in individuals with cognitive impairment. ...
Life's Essential 8, genetic susceptibility, and risk of cognitive impairment: results from an elder population-based cohort study [0.03%]
生命周期八大因素、基因易感性和认知障碍风险：一项基于老年人口队列研究的结果
Yutong Wang,Bowen Lei,Ke Jiang et al.
Yutong Wang et al.
Introduction: The American Heart Association's Life's Essential 8 (LE8) framework has been linked to cognitive impairment, but evidence in Chinese older adults remains limited. ...