Tianyi Zhang,Guoping Peng
Tianyi Zhang
Background: Emerging research highlights the role of the gut microbiome in the progress of Alzheimer's disease (AD). Alterations in serum bile acid (BA) profiles, reflecting gut microbial activity, have been observed in A...
Yuan Zhu,Xuewen Xiao,Tianyan Xu et al.
Yuan Zhu et al.
Background: Pathogenic short tandem repeat (STR) expansions cause many neurodegenerative diseases, including frontotemporal dementia (FTD), Huntington's Disease (HD) and neuronal intranuclear inclusion disease (NIID). The...
Ricardo D&#x;Oliveira,Taylor Bertucci,Elanur Yilmaz et al.
Ricardo D&#x;Oliveira et al.
Background: Cerebrovascular disorders are associated with an increased risk for neurodegenerative diseases, including Alzheimer's disease (AD). However, the mechanisms by which cerebrovascular dysfunction contributes to n...
Louyan Ma,Qiumin Qu
Louyan Ma
Background: Diabetes has been regarded as an independent risk factor for Alzheimer's disease(AD). This study investigates the effect of diabetes on autophagosome-lysosome fusion using STZ-induced diabetic rats and SH-SY5Y...
Huanyao Gao,Kate Jensen,Jarred Nesbitt et al.
Huanyao Gao et al.
Background: Early mechanisms of neuronal damage in Alzheimer's Disease (AD) include mitochondrial dysfunction and abnormal energy homeostasis. AD-associated mitochondrial signaling was shown to occur upstream of amyloid p...
Austin Talbot,Cristina E Trevino,Nicholas T Seyfried et al.
Austin Talbot et al.
Background: With the growing availability of large genetic and proteomic datasets there is unprecedented need for simplified, scalable methods for integrated omics analysis of Alzheimer's disease (AD). We have built 8 dis...
Ziyuan Huang,Vishaldeep Kaur Sekhon,Ouyang Guo et al.
Ziyuan Huang et al.
Background: Alzheimer's disease (AD) is a complicated neurodegenerative disorder influenced by dynamic interactions among clinical, microbial, and other complex underlying mechanisms. The Alzheimer's Disease Analysis Mode...
Louyan Ma,Qiumin Qu
Louyan Ma
Background: To investigate the molecular mechanism of the brain-gut peptide Ghrelin in improving cognitive function and attenuating Aβ deposition in hippocampal neurons. ...
Sarah R Pickles,Luca Gaiani,Lilian Lin et al.
Sarah R Pickles et al.
Background: Some cases of Alzheimer's Disease (AD) and Frontotemporal Dementia (FTD) feature the mislocalization of the normally nuclear TAR DNA binding protein (TDP-43) to the cytoplasm where it is incorporated into incl...
Jonathan Nyandu Kanyinda,Olivia J Marola,Gareth R Howell
Jonathan Nyandu Kanyinda
Background: Cerebral amyloid angiopathy (CAA) is the accumulation of amyloid beta (Aβ) in the walls of the cerebral vasculature. CAA can cause damage to the vasculature and disrupt proper functioning of the blood brain b...