Alesia V Prakapenka
Alesia V Prakapenka
Background: Pregnancy and perimenopause are female-specific reproductive events that are accompanied by drastic shifts to circulating ovarian hormone milieu. Ovarian hormones modulate female physiology, biology, and behav...
Sungjoon Park,Kyungwook Lee,Soorin Yim et al.
Sungjoon Park et al.
Background: Multi-omics data from large-scale consortium databases, such as the Religious Orders Study and Rush Memory and Aging Project (ROSMAP), combined with advanced AI technologies, hold significant promise for ident...
James P Owens,Frank J Castora
James P Owens
Background: A mutation in mitochondrial DNA (mtDNA) that is associated with Alzheimer's disease (AD) has been reported by us. We compared human brain RNA expression data from PCR array and bulk RNA seq analyses to underst...
John W McLean,Tian Wang,Yuan Shang et al.
John W McLean et al.
Background: Estrogen is a master regulator of systems biology in the female brain, coordinating metabolic, immune, and neuronal homeostasis. Loss of estrogen during menopausal transition is associated with declining brain...
Musa Omoyine Iliyasu,Abayomi Ajayi
Musa Omoyine Iliyasu
Background: Alzheimer's disease (AD), a progressive neurodegenerative disease, is the most common type of dementia affecting people over 65 years of age. The prevalence of AD is rising quickly because of extended lifespan...
Chun-Yen Yang,Aldarmaa Jalsrai,Hsiu-Mei Hsieh
Chun-Yen Yang
Background: Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by a progressive decline in cognitive functions. Key pathological features of AD include the accumulation of Aβ plaques, ...
Bryan Kartono,Liliana Attisano,Janice Robertson
Bryan Kartono
Background: Hexanucleotide repeat expansions in C9orf72 are the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The repeat expansions cause C9orf72 haploinsufficiency an...
Facundo Peralta,Ana Abril Vidal Escobedo,Juliette López Hanotte et al.
Facundo Peralta et al.
Background: As life expectancy continues to rise, neurodegenerative disorders like AD increasingly threaten global health, impacting both patients and healthcare systems. These conditions are characterized by the loss of ...
Andreas Huhmer,Zhengjian Zhang,Vivek Budamagunta et al.
Andreas Huhmer et al.
Background: The microtubule-associated protein Tau (MAPT) is implicated in various progressive neurodegenerative diseases, including Alzheimer's Disease (AD). With six primary splicing isoforms and over 70 different post-...
Korin Reid
Korin Reid
Background: There are more than 5.8 million Americans who suffer from Alzheimer's disease 1. By 2060 13.8 million Americans will be living with Alzheimer's Dementia 2. As of 2022, the financial burden of Alzheimer's Demen...