Nazaret Gamez,Abdulmunaim M Eid,Belen Pascual et al.
Nazaret Gamez et al.
Background: Despite growing evidence supporting the role of inflammation in neurodegenerative processes, a detailed molecular understanding of the peripheral immune system's status and its mechanistic implications in the ...
Alex J Edwards,Lily Camp,Anne V Forsyth et al.
Alex J Edwards et al.
Background: Recently approved Alzheimer's disease (AD) therapies leverage immunization strategies targeting amyloid-β (Aβ). While most studies focus on microglial responses to these treatments, evidence suggests that su...
Yuhan Cui,Dhivya Srinivasan,Zhijian Yang et al.
Yuhan Cui et al.
Background: Deep learning methods help to disentangle heterogeneity of brain aging and find distinct neuroimaging patterns of neurodegeneration. However, the relationship between aging-related brain atrophy patterns and g...
Zehu Sheng,Ming Chen,Jin Zhang et al.
Zehu Sheng et al.
Background: Leucine-rich repeat kinase 2 (LRRK2) is expressed in neurons and glial cells, but the potential role of LRRK2 in the progression of Alzheimer's disease (AD) and its impact on neuroinflammatory pathways remains...
Vincent Hervé,Obai BinB KaAli,Habib Benali et al.
Vincent Hervé et al.
Background: One of the main neuropathological hallmarks of Alzheimer's disease (AD) is the accumulation of amyloid-beta oligomers (Aβo), which begins in the brain approximately 15 years prior to the onset of clinical sym...
Beatriz Wagner,Mariana Chauvet,Sergio T Ferreira et al.
Beatriz Wagner et al.
Background: Neuroinflammation, oxidative stress and lipid peroxidation comprise key events in neurodegenerative diseases, such as Alzheimer's disease, and are associated with neuronal damage, synaptic loss and cognitive d...
Alejandro B Grau-Perales,Suhani Yerapathi,Ana Catarina Ferreira et al.
Alejandro B Grau-Perales et al.
Background: Alzheimer's disease (AD) is characterized by several pathological processes, including amyloid-beta (Aβ) accumulation and neuroinflammation, both of which have been linked to extracellular matrix (ECM) dyshom...
Ramon Bertoldi de Souza,Christian Limberger,Gabriel Colissi Martins et al.
Ramon Bertoldi de Souza et al.
Background: Astrocytes, the most abundant glial cells in the brain, exhibit remarkable heterogeneity and play critical roles in maintaining brain homeostasis. Their responses to Alzheimer's disease (AD) pathology are dive...
Kevin R Shen,George C Shum,Abby C Woods et al.
Kevin R Shen et al.
Background: Alzheimer's disease (AD) is characterized by the pathological accumulation of both amyloid-beta (Aβ) and cytoplasmic tau, but their mechanistic crosstalk remains to be further investigated. Moreover, while ch...
Ivan V Maksimovich
Ivan V Maksimovich
Background: Improved cerebral blood supply causes a decrease in atrophic changes in the subcortical white matter of the brain, leads to decreased dementia severity and cognitive functions improvement in the treatment of n...