Complex interplay of astrogliosis and pathology in preclinical Alzheimer's disease [0.03%]
未病至阿尔茨海默病小鼠模型中星形胶质细胞激活与病理变化的复杂互作关系
Alexandra Gogola,Davneet Minhas,Brian Lopresti et al.
Alexandra Gogola et al.
Introduction: We evaluated the effects of astrogliosis on Alzheimer's disease (AD) pathology, co-pathology, and symptoms. Methods: Cros...
Caution in interpreting disease-modification claims with lecanemab: Selective reporting and causal inference [0.03%]
解读lecanemab改变疾病进程的声明需谨慎：选择性报告和因果推断的问题
Lon S Schneider,Richard E Kennedy,Gary Cutter
Lon S Schneider
Associations of cognitive activity and access to resources with cognitive decline in a broad representation of older adults [0.03%]
认知活动和资源获取与老年人认知衰退的关系
Mayra L Estrella,Maude Wagner,Robert S Wilson et al.
Mayra L Estrella et al.
Introduction: Little is known about whether the cognitive benefits of cognitive activities and resources differ across ethno-racial groups in late-life. M...
2-aminobutyrate mediates the impact of air pollution on blood biomarkers of Alzheimer's disease [0.03%]
乙胺丁酸介导空气污染对阿尔茨海默病血液生物标志物的影响
Anum Saeed,Chris Mckennan,Jane E Clougherty et al.
Anum Saeed et al.
Introduction: We examined the impact of mid-life metabolites on late-life Alzheimer's disease (AD) plasma biomarkers and whether these metabolites mediate air pollution effects. ...
Evaluating the causal effect of mitochondrial dysfunction on Alzheimer's disease and Parkinson's disease using polygenic risk scores and Mendelian randomization [0.03%]
利用多基因风险评分和孟德尔随机化评估线粒体功能障碍对阿尔茨海默病和帕金森病的因果影响
Aadrita Chatterjee,Brian Alvarez,Rakshya U Sharma et al.
Aadrita Chatterjee et al.
Introduction: Mitochondrial DNA copy number (mtDNAcn), a measure of mitochondrial genomes per nucleated cell, has an unclear causal relationship with Alzheimer's disease (AD) and Parkinson's disease (PD). We integrated ge...
Circulatory pro-CTSD binds brain endothelial LRP1 to trigger its lysosomal degradation leading to amyloid beta clearance deficit in Alzheimer's disease mice [0.03%]
血液循环中的前CTSD结合到脑内皮LRP1上，触发其溶酶体降解，导致阿尔茨海默病小鼠中淀粉样蛋白β清除缺陷
Zhi-Jun Li,Zhao Yang,Dan Zhao et al.
Zhi-Jun Li et al.
Introduction: Clearance of cerebral Aβ was primarily mediated by the brain endothelial transporters including LRP1. The regulatory mechanism of LRP1 expression remained unclear. ...
Native PLGA nanoparticles attenuate disease pathology via multiple pathways in 5xFAD Alzheimer's model [0.03%]
基于PLGA的原代纳米颗粒通过多条通路抑制5XFAD阿尔茨海默病模型小鼠病理发展恶化
Govindarajan Karthivashan,Shuai Wang,Qi Wu et al.
Govindarajan Karthivashan et al.
Introduction: Elevated amyloid beta (Aβ) levels and aggregation contribute to neurotoxicity and development of Alzheimer's disease (AD), the leading cause of dementia in the elderly. While we reported that native poly(D,...
Phenotypic diversity of frontotemporal lobar degeneration in two novel GRN variants from Colombia [0.03%]
两个来自哥伦比亚的新型GRN变异体在额颞叶变性中的表型多样性
Juan Pablo Barbosa-Carvajal,Milena García-García,Luisa Fernanda Gómez Navarro et al.
Juan Pablo Barbosa-Carvajal et al.
Introduction: Pathogenic progranulin (GRN) variants are among the main genetic causes of frontotemporal lobar degeneration (FTLD). These variants have been predominantly reported in European cohorts, but their characteriz...
Reciprocal molecular and cellular cholinergic working memory impairments in Alzheimer's disease model mice [0.03%]
阿尔茨海默病模型小鼠中分子和细胞胆碱能工作记忆损伤的相互作用机制
Chloe I Rybicki-Kler,Isla A W Brooks,Izabela Jedrasiak-Cape et al.
Chloe I Rybicki-Kler et al.
Introduction: The degeneration of basal forebrain cholinergic neurons is a key pathophysiological feature of Alzheimer's disease (AD). These cholinergic neurons target cortical neurons including those in the granular retr...
Mixtures of key components of the external exposome in association with MRI biomarkers of brain structure: Multi-Ethnic Study of Atherosclerosis [0.03%]
基于多族裔动脉粥样硬化研究的外部暴露组关键成分混合物与脑结构MRI标志物相关性分析
Cameron J Reimer,Tara E Jenson,Yorghos Tripodis et al.
Cameron J Reimer et al.
Introduction: There is a critical need to identify risk factors of Alzheimer's disease and related dementias (ADRD). Methods: We includ...