Mapping the neurovascular landscape in aging and dementia: cerebral small vessel disease markers in a multicenter Latin American cohort [0.03%]
拉丁美洲多中心队列中的脑小血管病标志物：老龄化和痴呆神经血管景观的定位
Florencia Altschuler,Ana Maria Castro-Laguardia,Verónica Canziani et al.
Florencia Altschuler et al.
Introduction: Cerebral small vessel disease (CSVD) is a key contributor to cognitive impairment and dementia, yet few studies have compared CSVD across dementia variants, particularly in underrepresented populations. ...
Synaptic biomarkers in Alzheimer's disease dementia and mild cognitive impairment: A systematic review and meta-analysis [0.03%]
阿尔茨海默病痴呆和轻度认知障碍中的突触生物标志物：系统评价和meta分析
Amish Gaur,Melissa Wong,Jinghan Jenny Chen et al.
Amish Gaur et al.
Introduction: Alzheimer's disease (AD) is characterized by synaptopathy, a neuropathological feature that can contribute to underlying cognitive decline. Here, we evaluate potential cerebrospinal fluid (CSF) and blood-bas...
Non-verbal dichotic listening: A new cognitive hearing test for dementia [0.03%]
非言语双耳倾听测试：一种新的认知听力障碍筛查工具
Chris J D Hardy,Benjamin A Levett,Jessica Jiang et al.
Chris J D Hardy et al.
Introduction: Central hearing difficulties are a feature of Alzheimer's disease (AD) but not well captured by standard speech perception tests. Methods: ...
Systemic delivery of synapsin-promoted caveolin-1 overexpression ameliorates pathological TDP-43-induced cognitive decline and neurodegenerative changes [0.03%]
系统递送促进囊泡素-1过度表达缓解TDP-43病理性诱发的认知能力下降和神经退行性改变
Dongsheng Wang,Vinh Ta,Hongxia Wang et al.
Dongsheng Wang et al.
Introduction: Transactive response DNA-binding protein 43 (TDP-43) proteinopathy is associated with frontotemporal dementia and Alzheimer's disease (AD). We previously demonstrated that synapsin-promoted caveolin-1 (SynCa...
Performance of ICD-10 code-based dementia case definition in the Health and Retirement Study [0.03%]
基于ICD-10编码的痴呆病例定义在健康与退休研究中的表现
Kan Z Gianattasio,Michael Steffan,Ben Reist et al.
Kan Z Gianattasio et al.
Introduction: The Dementia DataHub (DDH) reports U.S. dementia prevalence and incidence from Medicare data. Variation in sensitivity, specificity, and accuracy of diagnoses related to geography and participant characteris...
Sleep and daily pain intensity among Black and White dementia caregivers [0.03%]
照料痴呆患者的护理人员的睡眠和日常疼痛强度：黑色人种与白色人种之间的对比研究
Yee To Ng,Daniel Whibley,Margaret Hicken et al.
Yee To Ng et al.
Introduction: Sleep problems and physical pain are prevalent among dementia caregivers. This study examines daily links between sleep and next-day pain, focusing on differences between Black and White caregivers. ...
Behavior of neural networks in culture suggest that sporadic and genetic forms of Alzheimer's disease may not be equivalent [0.03%]
培养中的神经网络行为表明阿尔茨海默病的散发型和遗传型可能并不等同
Fulin Ma,Himanshu Akolkar,Ryad Benosman et al.
Fulin Ma et al.
Introduction: Alzheimer's disease (AD) research often assumes that familial and sporadic forms share a common pathogenesis. However, the cellular impacts of amyloid precursor protein (APP) mutations compared with age-rela...
Social connection and cognitive health: A review of concepts, measures, and research priorities [0.03%]
社会联系与认知健康：概念、测量和研究重点的综述
Reed DeAngelis,Lindsey Burnside,Darby O Donnell et al.
Reed DeAngelis et al.
Lack of social connection is a major risk factor for Alzheimer's disease and related dementias, on a par with other common risk factors like physical inactivity and smoking. Yet we still know surprisingly little about how social connection ...
Empathy in primary progressive aphasia: Neural signatures and longitudinal trajectories [0.03%]
原发进行性失语症中的共情：神经标志物和纵向轨迹变化
Natacha Cordonier,Sophie Matis,Her Teng et al.
Natacha Cordonier et al.
Introduction: Empathy is increasingly recognised as compromised in neurodegenerative disorders. However, its profile and neural bases in the nonfluent (nfvPPA) and logopenic (lvPPA) variants of primary progressive aphasia...
Repurposed drug prioritization pipeline for a multi-arm platform trial in clinical Alzheimer's disease [0.03%]
一种用于临床阿尔茨海默病多臂平台试验的旧药优先级管道方法
Sabahat Iqbal,Cristina Bonet Olivares,Laura Rizzo et al.
Sabahat Iqbal et al.
Introduction: There is an urgent need to identify effective, safe, and affordable treatments for Alzheimer's disease (AD). Funded by the UK National Institute for Health and Care Research (NIHR), we developed a systematic...