Evolving national dementia policies in the OECD: Prevention, diagnosis, and care [0.03%]
经合组织国家痴呆症政策的发展：预防、诊断和护理
Soohyun Kim,Judit Rauet-Tejeda,Ricarda Milstein et al.
Soohyun Kim et al.
Dementia incurs yearly costs of nearly 1.3 trillion US dollars worldwide, projected to rise significantly in the coming decades due to population aging. This policy review provides an overview of the latest national dementia strategies, dia...
Evidence for direct and sleep-moderated relationships between aquaporin-4 genetic variants and Alzheimer's disease phenotypes [0.03%]
水通道蛋白-4遗传变异与阿尔茨海默病表型之间直接和睡眠调节关系的证据
Tenielle Porter,Ayeisha Milligan Armstrong,Eleanor K O&#x;Brien et al.
Tenielle Porter et al.
Introduction: Variants in the aquaporin-4 gene (AQP4) have been associated with Alzheimer's disease (AD) diagnosis, cognition, and brain amyloid beta (Aβ) and may affect the sleep and Aβ relationship. Their association ...
Sleep-like slow waves during resting-state: A promising EEG biomarker of amyloid and neurodegeneration in preclinical Alzheimer's disease [0.03%]
休息状态下的睡眠样慢波：一种有希望的用于识别未病癥阿尔茨海默病患者淀粉样蛋白和神经退行性变的EEG生物标志物
Pierre Champetier,Claudia Albero,Filipa Raposo Pereira et al.
Pierre Champetier et al.
Introduction: Growing evidence supports a critical role of sleep slow waves (SW) in Alzheimer's disease (AD). However, wake SW (sleep-like SW potentially reflecting local intrusions of sleep) remain unexplored in AD. ...
Peak width of skeletonized mean diffusivity reveals early and multifactorial white matter injury across sporadic and Down syndrome-associated Alzheimer's disease [0.03%]
基于骨架的平均扩散张量宽度表征散发和唐氏综合征相关阿尔茨海默病早期且多因素引起的白质损伤
Alejandra O Morcillo-Nieto,Maria Franquesa-Mullerat,Sara E Zsadanyi et al.
Alejandra O Morcillo-Nieto et al.
Introduction: This study investigates the evolution with disease progression and pathological correlates of peak width of skeletonized mean diffusivity (PSMD), a sensitive diffusion magnetic resonance imaging (MRI) marker...
Curated set of tool compounds to probe PYK2 and FAK signaling in Alzheimer's disease [0.03%]
一组用于探究阿尔茨海默病中PYK2和FAK信号传导的工具化合物集
Pathum M Weerawarna,Cynthia D Jesudason,Karen L Lobb et al.
Pathum M Weerawarna et al.
Introduction: Proline-rich tyrosine kinase 2 (PYK2) and focal adhesion kinase (FAK) are non-receptor tyrosine kinases implicated in Alzheimer's disease (AD), but their functional role in microglia remains understudied. Se...
Scalable markers for early cognitive decline: Plasma p-tau217, subjective cognitive concerns, and digital testing: Results from the A4/LEARN studies [0.03%]
适用于大规模筛查早期认知下降的标志物：血浆p-tau217，主观性认知担忧和数字测试：A4/LEARN研究结果
Babak Khorsand,Devin Teichrow,Elham Ghanbarian et al.
Babak Khorsand et al.
Introduction: Amyloid positron emission tomography (PET) and cerebrospinal fluid (CSF) biomarkers confirm Alzheimer's disease (AD) pathology but are impractical for large-scale screening. Plasma phosphorylated tau at thre...
Four decades of Alzheimer's disease discoveries, data, and research resources: The NIH Alzheimer's Disease Research Center Program [0.03%]
阿尔茨海默病四十年的发现、数据及研究资源：美国国立卫生研究院阿尔茨海默病研究中心项目
Grayson Donley,John Hsiao,Joseph Balintfy et al.
Grayson Donley et al.
The Alzheimer's Disease Research Centers (ADRC) program, funded by the National Institute on Aging (NIA), is a national network for conducting cutting-edge basic, clinical, and translational Alzheimer's disease (AD) and AD-related dementias...
Do white matter hyperintensities account for the relationship between discrimination and memory? [0.03%]
种族歧视导致的记忆力下降归因于白质高信号吗？
Robrielle M Pierce,Kiana A Scambray,Jordan D Palms et al.
Robrielle M Pierce et al.
Introduction: Racial discrimination (RD) relates to poorer memory, but underlying mechanisms are unclear. Methods: Participants include...
Recommendations for genetic counseling for individuals at risk of autosomal dominant Alzheimer's disease in Latin America [0.03%]
拉丁美洲载有突变基因的家族中早老素1基因遗传咨询的建议
Daniel A Jiménez,Pablo M Bagnati,Rosa Elena Flores-Montes et al.
Daniel A Jiménez et al.
Autosomal dominant Alzheimer's disease (ADAD) represents a small but impactful subset of Alzheimer's cases. Asymptomatic individuals at genetic risk face substantial personal and family implications when considering predictive testing for k...
Differences in amyloid PET positivity based on ethnoracial group and social determinants of health: The new IDEAS study [0.03%]
基于种族群体和健康的社会决定因素的淀粉样蛋白PET阳性差异：新的IDEAS研究发现
Corey J Bolton,Peggye Dilworth-Anderson,Jon Steingrimsson et al.
Corey J Bolton et al.
Introduction: This study leverages a large, diverse cohort to characterize ethnoracial differences in amyloid positron emission tomography (PET) positivity and identify social determinants of health (SDOHs) contributing t...