Prevalence of high-risk plasma p-tau217 levels and 5-year transition of risk status in 70-year-olds [0.03%]
70岁人群中高危血浆p-tau217水平的流行率及其5年的变化规律
Anna Dittrich,Burak Arslan,Tobias Skillbäck et al.
Anna Dittrich et al.
Introduction: High-risk plasma p-tau217 levels predict amyloid-β pathology in Alzheimer's disease, but little is known about the prevalence and temporal dynamics in the general population. ...
Midlife hypertension and late-life cognition: weighting the LifeAfter90 study [0.03%]
中年期高血压和晚年认知功能：LifeAfter90研究的证据权重分析
Hilary L Colbeth,Joseph N Roscoe,Maria M Corrada et al.
Hilary L Colbeth et al.
Introduction: Midlife hypertension is a well-established predictor of late-life cognitive decline; however, few population-representative estimates of this association exist among oldest-old cohorts. ...
Social vulnerability shapes deep clinical phenotypes and brain health in aging and dementia across Latin America [0.03%]
社会脆弱性塑造了拉丁美洲老龄和痴呆深临床表型和脑健康
Temitope Farombi,Tiago Azzi,Agustina Legaz et al.
Temitope Farombi et al.
Introduction: Adverse social conditions across the life course influence brain aging and dementia, yet their compounded impact on clinical phenotypes remains underexplored, particularly in Latin America, where social ineq...
Intraindividual cognitive variability predicts amyloid beta, tau PET, and dementia conversion in Down syndrome: a potential marker of cognitive resilience [0.03%]
唐氏综合症内个体认知变异性预测淀粉样蛋白β、tau正电子发射断层扫描及痴呆转化：认知坚韧的潜在标志物
Luciana Mascarenhas Fonseca,Eardi Lila,Ali Shojaie et al.
Luciana Mascarenhas Fonseca et al.
Introduction: Adults with Down syndrome (DS) are at risk for Alzheimer's disease (AD), yet identifying the preclinical phase remains challenging. Intraindividual cognitive variability (IICV) may be a sensitive marker of e...
Cerebral small vessel disease and cognition in older adults across the neurodegenerative spectrum: insights from the COMPASS-ND study [0.03%]
基于COMPASS-ND研究的神经退行性疾病老年人脑小血管病与认知的关系
Dylan X Guan,Zahinoor Ismail,Graham A McLeod et al.
Dylan X Guan et al.
Introduction: Imaging-based cerebral small vessel disease (CSVD) summary scores quantify CSVD burden. This study characterized CSVD scores and assessed their cognitive associations in older adults with various neurodegene...
Age-related increase in plasma p-tau217 in amyloid-beta-negative cognitively unimpaired individuals affects diagnostic interpretation [0.03%]
p-tau217的血浆水平在淀粉样蛋白阴性的无认知障碍老年人中会随年龄增长而增加，影响诊断解读
Anna E Mammel,Fernando Gonzalez-Ortiz,Ali Mousavi et al.
Anna E Mammel et al.
Introduction: The extent to which non-pathological aging influences plasma biomarkers remains unclear. Here, we investigate factors influencing plasma p-tau217 levels in cognitively unimpaired (CU), amyloid-beta-negative ...
Implementing multidomain non-pharmaceutical interventions for preventing cognitive decline in community-dwelling older adults in China: An embedded mixed-methods implementation study of determinants and strategies [0.03%]
中国社区居住老年人综合非药物干预预防认知衰退的实施研究：影响因素和策略的嵌入式混合方法实施研究
Zishuo Huang,Gonghang Qiu,Changmiao Shi et al.
Zishuo Huang et al.
Introduction: The WW-FINGERS network has demonstrated the efficacy of multidomain non-pharmaceutical interventions (NPIs) but left their real-world implementation largely unexplored, prompting this study in Changxing Coun...
Documented follow-up to memory concerns reported at the Medicare Annual Wellness Visit [0.03%]
关于Medicare年度健康访视中记录的有关记忆方面的顾虑的随访研究
Aleksandra Wec,Mingche Wu,Danny Scerpella et al.
Aleksandra Wec et al.
Introduction: The Medicare Annual Wellness Visit (AWV) may improve timely detection of Alzheimer's disease and related dementias (ADRD), yet little is known about the frequency of follow-up on patient-reported memory conc...
Reduction in hippocampal cholinergic neurostimulating peptide enhances memory impairment in AppNL-G-F KI mice [0.03%]
降低海马胆碱能神经刺激肽水平可增强APPNL-G-F基因工程小鼠的记忆损伤作用
Yo Tsuda,Yuta Madokoro,Kengo Suzuki et al.
Yo Tsuda et al.
Introduction: Whether cholinergic activity in the septohippocampal network affects cognitive dysfunction via hippocampal cholinergic neurostimulating peptide (HCNP) in Alzheimer's pathogenesis remains unclear. ...
Associations among sleep quality, cognitive decline, and Alzheimer's disease pathology in older adults: A longitudinal study [0.03%]
老年人睡眠质量、认知衰退和阿尔茨海默病病理变化纵向研究关系分析
Layaly Shihadeh,Mónica Rosselli,Joshua Conniff et al.
Layaly Shihadeh et al.
Introduction: This study aimed to investigate whether sleep quality predicts cognitive/functional decline, and whether Alzheimer's disease (AD) pathology modifies these relationships. ...