Brittany A Payan,Annika Carrillo Diaz De Leon,Tejasvi Anand et al.
Brittany A Payan et al.
Glioblastoma is the most common primary malignant brain tumor with a 5-year survival rate < 5%. The standard of care involves surgical resection followed by treatment with the alkylating agent temozolomide (TMZ). GBM cells that evade surger...
Construction of a Novel Mucin/Tannic Acid Hydrogel for Diabetic Wound Repair [0.03%]
用于糖尿病伤口修复的新型糖蛋白/单宁酸水凝胶的构建
Yilin Yue,Guozhen Chen,Xin Cui et al.
Yilin Yue et al.
The excessive accumulation of reactive oxygen species (ROS) and prolonged inflammatory response in diabetic wounds impair neovascularization, resulting in chronic wounds that cause significant pain and financial burden. To address this issu...
Controlled Antibiotic Release From Emulsion-Loaded Alginate and Fibrin Hydrogels Using Ultrasound [0.03%]
超声波控制明胶和纤维蛋白水凝胶中抗生素的缓释性能研究
Ziba Ghareh Nazi Fam,Asia Winslow,Mario L Fabiilli et al.
Ziba Ghareh Nazi Fam et al.
Postoperative infections remain a major complication after spinal fusion surgery, often caused by biofilm-forming bacteria that resist short-term antibiotic prophylaxis. Vancomycin (VAN) is sometimes delivered locally during surgery; howeve...
Investigation of Urinary Extracellular Vesicles as Novel and Safe Therapeutics for Autosomal Recessive Polycystic Kidney Disease (ARPKD) [0.03%]
尿液外泌体作为常染色体隐性多囊肾病（ARPKD）新型和安全治疗手段的研究
Yi Huang,Huihua Xing,Ali Osouli et al.
Yi Huang et al.
Autosomal recessive polycystic kidney disease (ARPKD) is a severe inherited disorder caused primarily by mutations in PKHD1 and in a minority of cases, CYS1. These genes encode fibrocystin and cystin, respectively. ARPKD typically manifests...
Hyaluronic Acid-Based, Double Network Hydrogels With Tunable Viscoelasticity for Neural Cell Culture [0.03%]
用于神经细胞培养的可调粘弹性的透明质酸基双网络水凝胶
Talia Sanazzaro,Sabrina Pietrosemoli Salazar,Neha Arvinth et al.
Talia Sanazzaro et al.
Brain tissue is the softest, most viscoelastic tissue in mammals and these mechanical properties strongly influence cell phenotypes. However, conventional hydrogels for 3D cultures rarely provide the ability to tune the elasticity (G') inde...
Comparative Analysis of Matrigel and Tunable Collagen-Fibrin Blends for in Vitro Skeletal Muscle Models [0.03%]
Matrigel与可调式胶原蛋白-纤溶酶模型在体外骨骼肌模型中的比较分析
Jorge A Mojica-Santiago,Gopal Agarwal,Steven Robles-Blasini et al.
Jorge A Mojica-Santiago et al.
In this study, we describe the gelation kinetics, cytocompatibility, and mechanical properties of interpenetrating networks of collagen (COL), fibrin (FIB), hyaluronan (HA), and laminin (LAM) to evaluate their potential to produce mature sk...
A Photoinitiator-Free Bioink Platform: Tyrosine-Assisted UV Crosslinking of Decellularized Extracellular Matrix/Zein Scaffolds Optimized by Full Factorial Design [0.03%]
无需光引发剂的生物墨水平台：全因子设计优化的脱细胞基质/玉米蛋白酶支架的酪氨酸辅助紫外线交联技术
Banuay Coşkun,Özlem Biçen Ünlüer
Banuay Coşkun
The clinical translation of 3D-bioprinted tissues is significantly limited by the cytotoxicity of synthetic photoinitiators used in photopolymerizable bioinks. To address this critical challenge, we developed a novel, fully photoinitiator-f...
Injectable Butyl Glycidyl Ether-Modified Methylcellulose Thermosensitive Hydrogel for Topical Delivery of Vancomycin Hydrochloride in the Treatment of Osteomyelitis [0.03%]
用于骨髓炎治疗的载氯化万古霉素可注射型丁基缩水甘油醚改性甲基纤维素热敏水凝胶的研究
Conggang Zhi,Guoqiang Wang,Bin Zhou et al.
Conggang Zhi et al.
Osteomyelitis (OM) is caused by the entry of septic cells into bone tissue. Due to systemic antibiotic side effects and drug resistance, local administration is a strategy for treating OM. In this study, a biodegradable, injectable thermose...
Fabrication of Titanium-Based Magnetic Composite Scaffold In Vitro Evaluation of Osteogenic Performance [0.03%]
钛基磁性复合支架的制备及体外骨诱导性能评价
Jie Zhang,Zengzilu Xia,Zhuoqi Xu et al.
Jie Zhang et al.
The biological inertness of Ti scaffolds prevents the proliferation and osteogenic differentiation of marrow mesenchymal stem cells (MSCs) on pure Ti scaffolds. Medical studies have shown that magnetic fields can promote the proliferation a...
A ROS-Responsive Hydrogel Microneedle System Co-Delivering Tofacitinib and Azelaic Acid for Enhanced Targeted Therapy of Rosacea [0.03%]
一种响应ROS的水凝胶微针系统联合递送托法替尼和辛酸以增强酒渣鼻的目标疗法
Yong Yu,Xiaoxia Ding,Yibin Fan et al.
Yong Yu et al.
Rosacea is a chronic inflammatory skin condition primarily affecting the face, characterized by symptoms such as persistent redness, visible blood vessels, papules, and pustules. Current treatments, including topical agents and systemic ant...