Hyaluronic Acid-Chitosan Nanoparticles Encapsulating Gal-9 Alleviate Severe Acute Pancreatitis by Promoting M2 Macrophage Polarization [0.03%]
Jing Dai,Xuechun Wang,Siyu Li et al.
Jing Dai et al.
Severe acute pancreatitis (SAP) is a prevalent gastrointestinal disease with no effective treatment to control inflammation currently. Macrophages, particularly peritoneal macrophages (PMOs), play a pivotal role in SAP inflammation by polar...
Surface Functionalization of TiO2 With an Albumin-Teicoplanin Complex to Prevent Implant-Associated Infections [0.03%]
Chitra Jagannathan,Jason P Mansell
Chitra Jagannathan
Postoperative infection and aseptic loosening are leading causes of orthopedic implant failure, often necessitating complex and costly revision surgeries. Teicoplanin (TP), a glycopeptide antibiotic effective against methicillin-resistant S...
Silver-Doped Mesoporous Bioactive Glass Nanoparticles With Core-Shell Architecture: Enhanced In Vitro Bioactivity, Antibacterial Efficacy, and Biocompatibility [0.03%]
Peerapat Thongnuek,Woranop Sukparangsi,Juntratip Jomrit et al.
Peerapat Thongnuek et al.
Orthopedic biomaterials must both prevent infection and support bone regeneration. To achieve both outcomes with bioactive glass nanoparticles (BGNs), rational nanoarchitectural design is required to decouple and tune silver-ion (Ag+) and c...
Recapitulating Native-Like Strain Distributions in a Tissue-Engineered Enthesis by Creating Structural, Biochemical, and Mineral Gradients [0.03%]
通过构建结构、生化和矿物质梯度在组织工程附着点再现原生的应变分布状态
Jongkil Kim,Alexander J Boys,Roland Babmatee et al.
Jongkil Kim et al.
The incorporation of robust meniscus-to-bone interfaces into tissue-engineered menisci is critical for their clinical translation. Generating gradients in collagen fiber organization and mineral content for tissue-engineered entheses is ess...
Poly-L-Lactic Acid Microspheres Promote Skin Rejuvenation via Enhanced Fibroblast Function [0.03%]
聚L-乳酸微球通过增强纤维细胞功能促进皮肤年轻化
Jennifer Geara,Lihua Luo,Onur Parlak et al.
Jennifer Geara et al.
Skin aging is marked by fibroblast decline and extracellular matrix (ECM) degradation, prompting the widespread use of poly-L-lactic acid (PLLA) dermal injectables for activating fibroblasts, stimulating neocollagenesis, and rejuvenating th...
Injectable Glycyrrhizic Acid Hydrogel Microspheres With Synergistic Anti-Senescence and Osteogenic Effects for Osteoporosis Therapy [0.03%]
一种可注射甘草酸水凝胶微球用于抗衰老促骨生成的协同治疗多功能递药系统
Yunchen Hong,Xiangyu Liu,Wenwen Mao et al.
Yunchen Hong et al.
Osteoporosis is an age-related bone disease closely associated with the accumulation of senescent cells in the bone marrow microenvironment, a pathological feature that is not fully addressed by current biomaterial-based therapies. Targetin...
Self-Assembling Synthetic Congener Collagen Mini-Fibrils With Genetically Encoded Hydroxyproline and 3,4-Dihydroxyphenylalanine for Wound Healing [0.03%]
一种用于伤口愈合的具有遗传编码的羟脯氨酸和3,4-二羟基苯丙氨酸的自组装合成胶原蛋白迷你微纤素类似物
Ashokraj Sundarapandian,Mohandass Pachaiyappan,Mayilvahanan Aarthy et al.
Ashokraj Sundarapandian et al.
Collagen-like proteins (CLPs) and their congeners can form stable triple helices but show limited fibril-forming ability, restricting their application as biomaterials. To more closely replicate the structural features of natural collagen, ...
Establishment of an In Vitro Neurovascular Unit Model With Blood and Brain Components and Investigation of Its Blood-Brain Barrier [0.03%]
一种包含血液和脑部成分的体外神经血管单元模型的建立及其血脑屏障的研究
Gozde E Kole,Tanil Kocagoz,Vasif Hasirci et al.
Gozde E Kole et al.
The neurovascular unit (NVU), including the blood-brain barrier (BBB), governs the interaction between neural tissue and blood vessels. The BBB is a highly selective interface that regulates molecular exchange between the bloodstream and th...
Additively Manufactured Metastable-β Ti-Nb-Zr-Sn Exhibits Superior Corrosion, Semiconducting, and Cell Metabolic Properties Over Ti-6Al-4V [0.03%]
添加制造亚稳-β型Ti-Nb-Zr-Sn材料具有优于Ti-6Al-4V的抗腐蚀性、半导体性质和细胞代谢性能
Michael A Kurtz,Nolwenn Rince,Paul M DeSantis et al.
Michael A Kurtz et al.
Manufacturers frequently use Ti-6Al-4V for permanently implanted medical devices. While clinically successful, Ti-6Al-4V corrodes at modular taper interfaces in both the hip and knee. Additionally, additive manufacturing (AM) can develop bi...
A Novel Radially Graded Hydroxyapatite-Based Composite for Bioactive Implant Interfaces [0.03%]
一种新型径向梯度羟基磷灰石生物活性植入体界面复合材料
Zeliha Coskun Tas,Talip Celik,Ibrahim Mutlu et al.
Zeliha Coskun Tas et al.
The combination of superior mechanical properties, corrosion resistance, and biological characteristics makes Ti-6Al-4V a widely used biomaterial. However, its clinical application as an orthopedic implant is limited by its hardness and wea...