Tiger Tongue-Inspired Bionic Microneedle Patch With Dual Mechanical-Pharmacological Functions for Enhanced Wound Healing [0.03%]
一种受虎舌启发的集成了力学和药物学功能的微针贴片促进伤口愈合
Yangguang Niu,Jingyuan Ren,Kangxun Zhao et al.
Yangguang Niu et al.
Effective skin wound healing requires reliable fixation and infection prevention. Inspired by the inclined papillary structure of the tiger's tongue, we developed a biomimetic microneedle patch that integrates mechanical stability with anti...
Self-Assembling Hydrogel for Controlled Release of bFGF and Ang-1 Mimetic Peptide Promotes Neurovascular Repair in Ischemic Stroke Rats [0.03%]
一种可自组装水凝胶同时控制递送bFGF和Ang-1模拟肽促进缺血性脑卒大鼠神经血管修复
Ange Nie,Weihong Nie,Na Zhou et al.
Ange Nie et al.
Self-assembling peptide hydrogels represent a promising strategy for growth factor delivery and tissue repair, with the advantage of sustained release and micro-environment response characteristics. In the present study, a multiple biofunct...
Safety, Distribution, and Pharmacokinetics of Biodegradable P(AAm-co-MAA) Nanogels Following Systemic Administration in Mice [0.03%]
口服P(AAm-co-Maa)纳米凝胶在小鼠体内的安全性、分布和药代动力学研究
Rana Ajeeb,Harsh Joshi,Mojtaba Ghanbari Mehrabani et al.
Rana Ajeeb et al.
Systematic analysis of the fate of hydrogel nanoparticles after in vivo administration is essential for their clinical translation. Biodegradable, disulfide-crosslinked synthetic nanogels are a promising platform for the delivery of therape...
Samyuktha S Kolluru,Abir Hamdaoui,Annabella M Mascot et al.
Samyuktha S Kolluru et al.
The vagina is a fibromuscular tube-shaped organ that plays critical roles in menstruation, pregnancy, and female sexual health. Vaginal tissue constituents, including cells and extracellular matrix components, contribute to tissue structure...
Investigating the Impact of Fused Filament Fabrication Process Parameters on the Compressive Properties of Porous PEEK and PEKK Biomaterials [0.03%]
研究融合沉积制造工艺参数对多孔PEEK和PEKK生物材料压缩性能的影响
Abigail E Tetteh,James A Smith,Daniel A Porter et al.
Abigail E Tetteh et al.
Additive manufacturing (AM) can create orthopedic devices with integrated porosity that enables bone fixation post-implantation. While porosity is key in promoting bone ingrowth and long-term fixation, the device must provide adequate mecha...
A New Perspective in Nanocellulose-Based Materials for Biomineralization and Strategies for Bone Repair [0.03%]
纳米纤维素基生物矿化材料的新视角及骨组织修复策略研究
Jonathan Michel Barba Godinez,Ernesto Tinajero-Díaz,Maria Soledad Peresin et al.
Jonathan Michel Barba Godinez et al.
Repairing large bone defects is a significant clinical challenge. In this context, cellulose nanomaterials, such as bacterial nanocellulose (BNC), cellulose nanofibrils (CNF), and cellulose nanocrystals (CNC), have emerged as promising alte...
Matrix-Dependent Effects of Phytic Acid on Konjac Glucomannan and Hyaluronic Acid Films for Biomedical Applications [0.03%]
基于矩阵的低聚半乳糖酸盐对蒟蒻葡甘露聚糖和透明质酸薄膜生物医学应用的影响
Lidia Zasada,Ipek Gencer,Dorota Chmielniak et al.
Lidia Zasada et al.
Chronic wounds and bacterial infections present significant challenges in tissue regeneration, demanding the development of advanced bioactive materials that balance biocompatibility, antimicrobial activity, and tunable physical properties....
Electrospun Silk Fibroin/Poly(Vinyl Alcohol) Nanofibrous Dressings Co-Loaded With Teicoplanin and Liposomal Curcumin: Fabrication, Physicochemical Characterization, and Antibacterial Performance [0.03%]
负载特拉万星和姜黄素脂质体的再生丝素/聚乙烯醇纳米纤维敷料：止咳糖浆的制备、物理化学性质及抗菌性能研究
Fariba Alizadeh Eghtedar,Jebrail Movaffagh,Amir Mahdi Molavi et al.
Fariba Alizadeh Eghtedar et al.
Electrospun silk fibroin (SF)/poly(vinyl alcohol) (PVA) nanofibrous mats co-loaded with teicoplanin (Tp) and nanoliposomal curcumin (LC) were fabricated to combine extracellular matrix (ECM) mimetic architecture with dual antimicrobial and ...
Research on the Combined Effects of miRNAs and Immunomodulatory Peptides on Bone Regeneration in an Inflammatory Bone Immunological Milieu [0.03%]
炎症骨免疫微环境下microRNAs与免疫调节肽联合促进成骨作用的研究
Yizhe Fu,Xinxiong Xia,Chang Liu et al.
Yizhe Fu et al.
The development of bone regenerative substitutes capable of orchestrating osteogenesis within inflammatory immune microenvironments remains a critical challenge. This study investigates the dual-functional immunomodulatory peptide DP7-C as ...
Murine Biocompatibility Evaluation of an Albumin-Derived Complex and Nanoparticle Delivery System for Ocular Applications [0.03%]
用于眼部应用的白蛋白衍生成分和纳米粒子输送系统的小鼠生物相容性评价
Amna Abdalbaqi,Nagaraj Kerur,Matthew P Ohr et al.
Amna Abdalbaqi et al.
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the aging population, with no curative treatment currently available. Current therapies primarily target late-stage symptoms and are limited by their f...