Targeting Cell-Matrix Induced Chemoresistance With Regorafenib in a 3D Model of Osteosarcoma [0.03%]
雷戈拉非滨在三维成骨肉瘤模型中靶向细胞-基质诱导的化疗抗性
Rameshwar R Rao,Michelle S Huang,Daiyao Zhang et al.
Rameshwar R Rao et al.
Over the past four decades, there has been little advancement in treatment strategies for osteosarcoma (OS), the predominant primary bone tumor in the pediatric patient population. Current therapy involves multiple rounds of chemotherapy an...
Therapeutic Effect of a Composite Acellular Matrix/Hyaluronic Acid Thermosensitive Hydrogel for the Interstitial Cystitis/Bladder Pain Syndrome in a Rat Model [0.03%]
一种复合脱细胞基质/透明质酸热致凝胶治疗间质性膀胱炎/膀胱疼痛综合征的疗效研究
Haichao Liu,Wei Guo,Jianzhong Zhang et al.
Haichao Liu et al.
This study investigated the therapeutic effects of a composite small intestinal submucosa decellularized extracellular matrix/hyaluronic acid (HA)-incorporated thermosensitive hydrogel (HA-Gel) on interstitial cystitis (IC) in rats. The HA-...
Implantable Medical Devices, Biomaterials, and the Foreign Body Response: A Surgical Perspective [0.03%]
植入式医疗器械、生物材料及异物反应：外科视角
Nikita Kalashnikov,Jake Barralet,Joshua Vorstenbosch
Nikita Kalashnikov
Implantable medical devices improve quality of life and reduce mortality by restoring the form and function of the human body. Their biomaterial surface components in contact with tissues are, however, susceptible to the host's foreign body...
Efficacy of 3D-Printed Bioactive Glass Tetrahedral Particles for Vertical Bone Regeneration: A Comparative Study [0.03%]
一种用于垂直骨再生的3D打印生物活性玻璃四面体颗粒的效果研究：一项比较研究
Wenjie Wang,Liya Ai,Lingling Zheng et al.
Wenjie Wang et al.
This study was designed to systematically evaluate the osteogenic efficacy of 3D-printed tetrahedral bioactive glass particles in vertical bone regeneration and compare their performance with that of conventional bone substitute materials. ...
Guoyao Chen,Sharon Creason,Ningjing Chen et al.
Guoyao Chen et al.
Precision porous scaffolds hold promise for tissue engineering and regenerative medicine due to their ability to support cell ingrowth and vascularization and mitigate the foreign body reaction (FBR). In previous work, we demonstrated that ...
Gyroid-Structured Scaffolds Guide Uniform Ossification and Modulate Vascular Morphology During Rat Calvarial Bone Defect Regeneration [0.03%]
具gyroid结构的骨支架引导均匀骨骼化并调节血管形态学在大鼠颅骨缺陷再生过程中的作用
Guoyan Xian,Baptiste Charbonnier,Morad Bensidhoum et al.
Guoyan Xian et al.
Bone repair procedures rely on osteoconductive material scaffolds that guide and promote bone ingrowth through their architecture. This study investigated how the bone formation and vascularization are modulated within gyroid macroporous sc...
Multifunctional Characteristics of Cu/Zn Co-Doped Hydroxyapatite: Enhanced Electrical, Surface, and Biocompatibility [0.03%]
Cu/Zn共掺杂羟基磷灰石的多功能特性：增强的电学性能、表面特性和生物相容性
M Durga Ganesh,Mukesh Kumar Manickasamy,P Joel et al.
M Durga Ganesh et al.
Developing multifunctional biomaterials with both electrical and biological properties is crucial for next-generation biomedical platforms. This study looks into how Cu/Zn co-doping affects the structural, electrical, and biological perform...
Design of a Corrugated Vascular Graft with Enhanced Compliance and Kink Resistance [0.03%]
一种设计增强顺应性及抗折性的波纹血管移植物的研究
Andrew Robinson,Juan S Herrera Duran,David Jiang et al.
Andrew Robinson et al.
The development of a small-diameter vascular graft for coronary artery bypass grafting necessitates a balance of key biomechanical properties to prevent failure. Prior iterative design of a multilayer vascular graft achieved arterial compli...
Fish Collagen-Based Bilayer Composite Scaffold Functionalized With Fibrin/Hydroxyapatite/Sodium Citrate for Osteochondral Tissue Engineering-In Vitro and In Vivo Studies [0.03%]
一种基于鱼胶原蛋白的双层复合支架用于软骨-骨组织工程的研究（体外及体内研究）
Ashwathi Vijayalekha,Suresh Kumar Anandasadagopan,Thiyagarajan Gopal et al.
Ashwathi Vijayalekha et al.
Osteochondral defects (OCDs) present significant clinical challenges, necessitating scaffolds that effectively regenerate both cartilage and subchondral bone. We developed a bilayer scaffold using fish collagen extracted from Catla catla sk...
Development and Characterization of Hyaluronic Acid Microgels for Neural Regeneration Applications [0.03%]
用于神经再生应用的透明质酸微凝胶的开发与表征
Kassondra N Hickey,Shannon M Grassi,George R Bjorklund et al.
Kassondra N Hickey et al.
Delivery of therapeutic compounds via biomaterial systems has shown promise for tissue regeneration following central nervous system (CNS) injuries. Stromal cell-derived factor-1a (SDF-1a) modulates progenitor cell recruitment to neural inj...