Reduced Hypotonic Exposure and Sequential Membrane Cholesterol Enrichment Limit Phosphatidylserine Externalization and Enhance Circulatory Retention of Erythrocyte-Derived Microparticles [0.03%]
低渗暴露减少和顺序膜胆固醇丰富限制磷脂酰丝氨酸外化并增强红细胞衍生微粒的循环保留
Shamima Zaman,Grant Swajian,Shiril Bhardwaj Iragavarapu et al.
Shamima Zaman et al.
Erythrocyte-derived carriers have emerged as effective biomimetic platforms for the delivery of therapeutic and imaging cargos. However, clearance by the mononuclear phagocytic system (MPS) limits their utility. Towards development of stand...
Reciprocal Macrophage-MSC Crosstalk Drives Immunomodulatory and Regenerative Phenotypes in a Mineralized Collagen Scaffold [0.03%]
相互作用的巨噬细胞-间充质干细胞在矿化胶原支架中驱动免疫调节和再生表型现象
Vasiliki Kolliopoulos,Maxwell Polanek,Hashni E Vidana Gamage et al.
Vasiliki Kolliopoulos et al.
Critical sized craniomaxillofacial bone defects do not heal naturally and often exhibit chronic inflammatory responses that restrict regeneration. It is increasingly apparent that biomaterials must facilitate dynamic crosstalk between immun...
Controlled Glutathione-Releasing Multifunctional Gelatin Methacryloyl/Chitosan/Zeolite Hydrogels for Accelerated Regeneration in Diabetic Wounds [0.03%]
控释谷胱甘肽多功能GelMA/壳聚糖/沸石水凝胶促进糖尿病伤口加速再生
Fatma Betul Kabadas,Tuba Bedir,Elif Ilhan et al.
Fatma Betul Kabadas et al.
Chronic diabetic wounds remain a major clinical challenge because of persistent inflammation, excessive oxidative stress, impaired angiogenesis, and high susceptibility to infection. This study aims to develop a multifunctional hydrogel sys...
A Multifunctional Electrospun Membrane for Full-Thickness Abdominal Wall Defect Repair [0.03%]
一种用于腹壁全层缺损修复的多功能电纺膜
Qiaolin Ma,Jiajie Liu,Rui Tang et al.
Qiaolin Ma et al.
Electrospun nanofiber membranes hold promise for abdominal wall repair due to their biomimetic architecture and tunable properties. However, their porous structure often induces an elevated foreign body response (FBR) that impedes tissue in...
Ceragenin-Loaded Tri-Layered Skin Substitute Composed of Natural and Synthetic Biopolymers for Burn Wound Healing [0.03%]
一种负载有阳离子小分子的三层人工皮肤及其在烧伤创面修复中的应用研究
Nawal Aljayyousi,Emel Tamahkar Irmak,Esra Karaca et al.
Nawal Aljayyousi et al.
Burn wounds present significant clinical challenges due to high infection risk, delayed healing, and extensive tissue damage. The development of biomimetic skin substitutes capable of simultaneously supporting tissue regeneration and preven...
Development and Characterization of Collagen Composites With Chemically Functionalized Mesoporous Silica Particles for Bone Tissue Engineering Applications [0.03%]
用于骨组织工程应用的化学官能化介孔硅颗粒胶原复合材料的开发与表征
Christian E Olivetti,María I Alvarez Echazú,Sandra J Renou et al.
Christian E Olivetti et al.
Mesoporous silica particles (MSPs) are widely investigated in biomaterials due to their high surface area, tunable porosity, and potential for chemical functionalization. In this study, MSPs were modified with different anionic functional g...
Pepsin Concentration Affects Structural, Physico-Chemical, Mechanical, and Biological Properties of Decellularized Extracellular Matrix Hydrogels [0.03%]
胃蛋白酶浓度影响脱细胞基质水凝胶的结构、理化、机械和生物性能
Mariana Pires Figueiredo,Francesco Copes,Silvia Rodríguez-Fernández et al.
Mariana Pires Figueiredo et al.
Decellularized extracellular matrix (dECM) has emerged as a promising material for tissue engineering and regenerative medicine (TERM), particularly for hydrogel development. Although dECM offers unmatched biochemical complexity compared to...
Tissue-Material Characteristics Determine Fibrous Encapsulation Dynamics Across Common Polymeric Surgical Biomaterials in a Tissue-Specific Mouse Foreign Body Response Model [0.03%]
基于组织的材料特性决定常见聚合物外科生物材料在特异性小鼠异物反应模型中成纤维细胞包囊动力学现象
Nikita Kalashnikov,Rahul Thareja,Joshua Vorstenbosch
Nikita Kalashnikov
Common polymeric surgical biomaterials are susceptible to dysregulated fibrous encapsulation, which contributes to failure in 10% of implantable medical devices. While biomaterial factors influencing the underlying foreign body response hav...
Evaluating the Effects of Poly(ε-Caprolactone)-Nanohydroxyapatite Composition on 3D-Printed Scaffold Structural Properties [0.03%]
聚己内酯-纳米羟基磷灰石组成对3D打印支架结构性能的影响评估
Maeve M Kennedy,Vasiliki K Kolliopoulos,Konstantinos Loukelis et al.
Maeve M Kennedy et al.
Bone tissue engineering scaffolds should be biocompatible, match the mechanical properties of native bone, and degrade at a rate that facilitates tissue regeneration. However, most scaffolds will excel in only one or two of these areas whil...
Edward B Gordon,Amin Nikkhah,Sabrina Madiedo-Podvrsan et al.
Edward B Gordon et al.
Cellular agriculture represents the intersection of biomaterials and cell science aimed at achieving high-quality, protein-rich, sustainable products. Developing cultivated meat products that address environmental and societal challenges re...