Pepsin Concentration Affects Structural, Physico-Chemical, Mechanical, and Biological Properties of Decellularized Extracellular Matrix Hydrogels [0.03%]
胃蛋白酶浓度影响脱细胞基质水凝胶的结构、理化、机械和生物性能
Mariana Pires Figueiredo,Francesco Copes,Silvia Rodríguez-Fernández et al.
Mariana Pires Figueiredo et al.
Decellularized extracellular matrix (dECM) has emerged as a promising material for tissue engineering and regenerative medicine (TERM), particularly for hydrogel development. Although dECM offers unmatched biochemical complexity compared to...
Tissue-Material Characteristics Determine Fibrous Encapsulation Dynamics Across Common Polymeric Surgical Biomaterials in a Tissue-Specific Mouse Foreign Body Response Model [0.03%]
基于组织的材料特性决定常见聚合物外科生物材料在特异性小鼠异物反应模型中成纤维细胞包囊动力学现象
Nikita Kalashnikov,Rahul Thareja,Joshua Vorstenbosch
Nikita Kalashnikov
Common polymeric surgical biomaterials are susceptible to dysregulated fibrous encapsulation, which contributes to failure in 10% of implantable medical devices. While biomaterial factors influencing the underlying foreign body response hav...
Evaluating the Effects of Poly(ε-Caprolactone)-Nanohydroxyapatite Composition on 3D-Printed Scaffold Structural Properties [0.03%]
聚己内酯-纳米羟基磷灰石组成对3D打印支架结构性能的影响评估
Maeve M Kennedy,Vasiliki K Kolliopoulos,Konstantinos Loukelis et al.
Maeve M Kennedy et al.
Bone tissue engineering scaffolds should be biocompatible, match the mechanical properties of native bone, and degrade at a rate that facilitates tissue regeneration. However, most scaffolds will excel in only one or two of these areas whil...
Edward B Gordon,Amin Nikkhah,Sabrina Madiedo-Podvrsan et al.
Edward B Gordon et al.
Cellular agriculture represents the intersection of biomaterials and cell science aimed at achieving high-quality, protein-rich, sustainable products. Developing cultivated meat products that address environmental and societal challenges re...
Novel Antibiofilm Approach Using Bioactive Glasses F18 and 45S5 Against Clinical Isolates of Staphylococcus aureus in Chronic Rhinosinusitis [0.03%]
针对慢性鼻窦炎临床分离株的金黄色葡萄球菌的新抗菌膜方法：使用生物活性玻璃F18和45S5
João Vitor Bizinoto Caetano,Maria Clara Antunes Alves,Marina Zilio Fantucci et al.
João Vitor Bizinoto Caetano et al.
S. aureus plays a central role in chronic rhinosinusitis (CRS), contributing to acute exacerbations and persistent infections through biofilm formation. With rising antibiotic resistance, bioactive glasses such as F18 and 45S5 have emerged ...
Recombinant N-terminal Fragment of Human Vitronectin Promotes Osteoblast Adhesive Responses via αvβ3 and αvβ5 Integrins [0.03%]
人 vitronectin 重组N端片段通过αvβ3和αvβ5整联蛋白促进成骨细胞黏附反应
O Bok Kim,Sung Youn Jung,Byung-Moo Min
O Bok Kim
Vitronectin is a key extracellular matrix glycoprotein, but the functional contribution of specific residues within its N-terminal region to osteoblast activity remains poorly defined. We engineered a recombinant N-terminal fragment of huma...
Biocompatibility and Therapeutic Potential of Cinnamoyl-Diphenylalanine Dipeptide: A Double-Edged Sword [0.03%]
肉桂二苯基丙氨酸肽的生物相容性和治疗潜力：一把双刃剑
Efstratios D Sitsanidis,Visa Ruokolainen,Kari Kunnas et al.
Efstratios D Sitsanidis et al.
This study evaluates cinnamoyl-diphenylalanine dipeptide (Cin-FF), a newly introduced gelator, for its antimicrobial efficacy, biocompatibility, and potential anticancer properties in solution and gel forms. We show that Cin-FF exhibits ant...
Real Architecture for 3D Tissue (RAFT): Mechanical Properties and Ability to Support the 3D Culture of Porcine Corneal Endothelial Cells [0.03%]
用于培养猪角膜内皮细胞的三维组织真实架构（RAFT）力学特性及其三维培养能力
Meng-Chen Tsai,Alvena Kureshi,Julie T Daniels
Meng-Chen Tsai
A suitable tissue-engineered equivalent is necessary to support cultured cells for cell therapy transplantation, thereby alleviating the increasing demand for donor tissue. A compressed collagen I hydrogel, Real Architecture For 3D Tissue (...
A Cationic Block Co-Polymer for Gene Delivery in the Posterior Segment of the Eye [0.03%]
一种用于眼后段基因传递的阳离子嵌段共聚物
Amber Monteiro,Odunayo O Mugisho,Antonio de Souza et al.
Amber Monteiro et al.
Diseases of the back of the eye such as neovascular age-related macular degeneration (nAMD) are vision threatening and treatment is burdensome for patients, often requiring ocular injections every other month. Injection risks and logistics ...
Reconstruction of Tissue-Engineered Conjunctiva Using Human Amniotic Epithelial Cells and Decellularized Porcine Conjunctiva Matrix With RADA16-I Peptide Hydrogel in a Perfusion Culture System [0.03%]
Dong Yuying,Liu Jingwen,Chen Fangyuan et al.
Dong Yuying et al.
Extensive conjunctival defects present significant clinical challenges due to limitations of current treatments including donor scarcity, immune rejection, and suboptimal graft outcomes. In this study, we developed a tissue-engineered conju...