In Vitro Assessment and Preliminary In Vivo Characterization of Innovative Hybrid Materials for Biomedical Applications [0.03%]
用于生物医学应用的创新混合材料的体外评估和初步体内特征分析
Martina Todesco,Roberto Luisetto,Martina Casarin et al.
Martina Todesco et al.
Hybrid materials are gaining increasing attention for several applications since they properly combine biological and synthetic components, leveraging the advantages of both; thus, these materials can integrate with the host organism to sup...
Modulating Hydrogel Stiffness Through Light-Based 3D Printing to Mimic Cardiac Fibrosis and Cardiomyocyte Dysfunction Using hiPSC-Derived Cells [0.03%]
基于光的3D打印调节水凝胶刚度以模拟心脏纤维化和hiPSC衍生细胞的心肌细胞功能障碍
Sogu Sohn,Nima Momtahan,Lynn M Stevens et al.
Sogu Sohn et al.
The human heart's limited regenerative capacity is a significant barrier to addressing cardiovascular disease (CVD). This is particularly true for cardiac fibrosis, a form of CVD wherein the wound healing process has gone awry. In cardiac f...
GelMA Hydrogel Encapsulating iPSC-Derived Human Spinal Cord Organoids Enhances Neural Regeneration and Restores Motor Function in Rat Spinal Cord Injury [0.03%]
封装人脊髓类器官的凝胶毛细管促进受损大鼠脊髓的神经再生和运动功能恢复
Yiheng Li,Yifan Gu,Ziru Wang et al.
Yiheng Li et al.
Spinal cord injury (SCI) severely compromises neural regeneration due to limited intrinsic repair capacity. Combining induced pluripotent stem cell (iPSC)-derived organoids with biomaterial scaffolds offers a promising regenerative strategy...
Decellularised Cartilage-Based Hydrogels Functionalised With Chondroitin Sulphate and Quercetin: The Impact on Chondrogenesis [0.03%]
脱细胞软骨基水凝胶功能化硫酸软骨素和槲皮素对软骨生成的影响
Nuno Da Silva Rosa,Nuno Neves,Michael Gelinsky et al.
Nuno Da Silva Rosa et al.
Tissue engineering and regenerative medicine approaches are being actively developed for degenerative disorders, including osteoarthritis (OA). Decellularized matrix (dECM) is a promising biomaterial; however, glycosaminoglycan (GAG) loss d...
Decellularised Cartilage-Based Hydrogels Functionalised With Chondroitin Sulphate and Quercetin: The Impact on Chondrogenesis [0.03%]
脱细胞软骨基水凝胶功能化硫酸软骨素和槲皮素对软骨生成的影响
Nuno Da Silva Rosa,Nuno Neves,Michael Gelinsky et al.
Nuno Da Silva Rosa et al.
Tissue engineering and regenerative medicine approaches are being actively developed for degenerative disorders, including osteoarthritis (OA). Decellularized matrix (dECM) is a promising biomaterial; however, glycosaminoglycan (GAG) loss d...
Triamcinolone Acetonide (TCA)-Loaded Biodegradable Microspheres Improve Therapeutic Outcomes in Thyroid-Associated Ophthalmopathy (TAO) by Reducing Fibrosis and Adipogenesis [0.03%]
载有三氟醋酸倍他米松的可降解微球通过减少纤维化和脂肪生成改善甲状腺相关性眼病的治疗效果
Bingyu Xie,Wei Xiong,Feng Zhang et al.
Bingyu Xie et al.
Thyroid-associated ophthalmopathy (TAO) is an inflammatory orbital disease linked to thyroid dysfunction, leading to fibrosis and adipogenesis, which compromise visual acuity and quality of life. Triamcinolone acetonide (TCA) is effective i...
Biochemical and Biophysical Properties of Extracellular Matrix Nanofibers Modulate iPSC-Derived Human Hepatocyte Maturation [0.03%]
细胞外基质纳米纤维的生化和生物物理性质调节诱导多能干细胞来源的人肝细胞成熟
Yang Yuan,Liszt C Madruga,Kristen Y Cotton et al.
Yang Yuan et al.
Human liver models grown in the lab are used for testing drug metabolism and toxicity, studying liver diseases, and developing new therapies. Induced pluripotent stem cell (iPSC)-derived hepatocyte-like cells (HLCs) provide a renewable alte...
Biodegradable Piezoelectric Zinc Oxide Composite Scaffolds Affect Mesenchymal Stem Cell Osteochondral Differentiation Under Mechanical Loading [0.03%]
生物可降解压电ZnO复合支架通过机械刺激影响间充质干细胞成软骨分化方向
A Khader,A Limaye,T L Arinzeh
A Khader
Bone and cartilage tissue have known piezoelectric properties, which means the tissues can generate electrical activity in response to mechanical deformation. Piezoelectricity may be an important physical cue for regenerating tissues. Howev...
Mechanisms of Osteoblast-Like Cells and Bacterial Responses to Copper in Titanium-Copper Alloys [0.03%]
钛铜合金中铜对成骨细胞样细胞和细菌的调控机制研究
Javeria Khalid,Abish S Stephen,Simon C F Rawlinson et al.
Javeria Khalid et al.
Titanium-copper (Ti-Cu) alloys are gaining attention for their dual functionality in promoting osteogenesis while providing antimicrobial protection, making them ideal candidates for dental and orthopedic implants. Copper's ability to enhan...
Carrier-Free Nanomaterials Simultaneously Combat Infection and Inflammation for Enhanced Diabetic Wound Healing [0.03%]
一种用于糖尿病伤口治疗的无载体纳米材料抗菌抗炎促进创面愈合的新策略
Ke Wang,Jue Zhang,Bing Han et al.
Ke Wang et al.
Diabetic wound ulcers, characterized by chronic infection and persistent inflammation, significantly impair patient quality of life and present substantial socioeconomic burdens. Traditional therapeutic strategies frequently encounter chall...