Biomaterial-Focused Strategies Targeting Dendritic Cells for Autoimmune Disease Treatment [0.03%]
以树突状细胞为目标的生物材料聚焦策略在自身免疫性疾病治疗中的应用
Aiswarya Venkata Suresh Kumar,Julia Babensee
Aiswarya Venkata Suresh Kumar
Autoimmune diseases encompass over 100 distinct diseases where the immune cells betray our body by attacking the tissues they are meant to protect. Even though rare, 15 million Americans are collectively affected by autoimmune diseases, a n...
Engineering Pro-Osteogenic Poly(l-Lactide-co-ε-caprolactone) Sponges Through Carbonate Apatite Integration [0.03%]
通过碳酸羟基磷灰石集成工程化促成骨聚(l-乳酸-co-ɛ-癸内酯)海绵
Zhanrui Lou,Ryo Kishida,Akira Tsuchiya et al.
Zhanrui Lou et al.
Flexible and porous sponges with high osteoconductivity have a wide range of bone healing applications. Although polymer/ceramic composite materials can serve as soft bone grafts, osteogenesis can be compromised when the ceramic surface is ...
Evaluation of Ethyl Cellulose-Ethanol Ablation in a Human-Sized 3D Construct of High-Grade Cervical Dysplasia [0.03%]
乙基纤维素-乙醇消融评价高危型宫颈上皮内瘤变三维模型的疗效
Gatha Adhikari,Alina Sharma,Kaitlin C Fogg et al.
Gatha Adhikari et al.
Current preclinical models for cervical dysplasia rely on animal systems that poorly mimic human anatomy. To address this and align with emerging initiatives to reduce animal experimentation, we developed a human-sized, 3D in vitro model of...
Mechanical Enhancement of Silk Fibroin Hydrogel Generated From Genetically-Modified Bombyx mori Cocoons and Promotes Osteogenesis [0.03%]
通过家蚕遗传改性获得的丝素蛋白水凝胶及其促骨形成性能研究
Huan-Xin He,Yu-Kai Huang,Zhi-Yang Gao et al.
Huan-Xin He et al.
Regenerated silk fibroin (RSF) from Bombyx mori is well known for its outstanding biocompatibility, biodegradability, and mechanical characteristics. Spider silk has even better strength and extensibility and is considered one of the best s...
Reduced Hypotonic Exposure and Sequential Membrane Cholesterol Enrichment Limit Phosphatidylserine Externalization and Enhance Circulatory Retention of Erythrocyte-Derived Microparticles [0.03%]
低渗暴露减少和顺序膜胆固醇丰富限制磷脂酰丝氨酸外化并增强红细胞衍生微粒的循环保留
Shamima Zaman,Grant Swajian,Shiril Bhardwaj Iragavarapu et al.
Shamima Zaman et al.
Erythrocyte-derived carriers have emerged as effective biomimetic platforms for the delivery of therapeutic and imaging cargos. However, clearance by the mononuclear phagocytic system (MPS) limits their utility. Towards development of stand...
Reciprocal Macrophage-MSC Crosstalk Drives Immunomodulatory and Regenerative Phenotypes in a Mineralized Collagen Scaffold [0.03%]
相互作用的巨噬细胞-间充质干细胞在矿化胶原支架中驱动免疫调节和再生表型现象
Vasiliki Kolliopoulos,Maxwell Polanek,Hashni E Vidana Gamage et al.
Vasiliki Kolliopoulos et al.
Critical sized craniomaxillofacial bone defects do not heal naturally and often exhibit chronic inflammatory responses that restrict regeneration. It is increasingly apparent that biomaterials must facilitate dynamic crosstalk between immun...
Controlled Glutathione-Releasing Multifunctional Gelatin Methacryloyl/Chitosan/Zeolite Hydrogels for Accelerated Regeneration in Diabetic Wounds [0.03%]
控释谷胱甘肽多功能GelMA/壳聚糖/沸石水凝胶促进糖尿病伤口加速再生
Fatma Betul Kabadas,Tuba Bedir,Elif Ilhan et al.
Fatma Betul Kabadas et al.
Chronic diabetic wounds remain a major clinical challenge because of persistent inflammation, excessive oxidative stress, impaired angiogenesis, and high susceptibility to infection. This study aims to develop a multifunctional hydrogel sys...
A Multifunctional Electrospun Membrane for Full-Thickness Abdominal Wall Defect Repair [0.03%]
一种用于腹壁全层缺损修复的多功能电纺膜
Qiaolin Ma,Jiajie Liu,Rui Tang et al.
Qiaolin Ma et al.
Electrospun nanofiber membranes hold promise for abdominal wall repair due to their biomimetic architecture and tunable properties. However, their porous structure often induces an elevated foreign body response (FBR) that impedes tissue in...
Ceragenin-Loaded Tri-Layered Skin Substitute Composed of Natural and Synthetic Biopolymers for Burn Wound Healing [0.03%]
一种负载有阳离子小分子的三层人工皮肤及其在烧伤创面修复中的应用研究
Nawal Aljayyousi,Emel Tamahkar Irmak,Esra Karaca et al.
Nawal Aljayyousi et al.
Burn wounds present significant clinical challenges due to high infection risk, delayed healing, and extensive tissue damage. The development of biomimetic skin substitutes capable of simultaneously supporting tissue regeneration and preven...
Development and Characterization of Collagen Composites With Chemically Functionalized Mesoporous Silica Particles for Bone Tissue Engineering Applications [0.03%]
用于骨组织工程应用的化学官能化介孔硅颗粒胶原复合材料的开发与表征
Christian E Olivetti,María I Alvarez Echazú,Sandra J Renou et al.
Christian E Olivetti et al.
Mesoporous silica particles (MSPs) are widely investigated in biomaterials due to their high surface area, tunable porosity, and potential for chemical functionalization. In this study, MSPs were modified with different anionic functional g...