Combining Supramolecular and Covalent Chemistry to Form Reinforced Fibrillar Network Hydrogels From Fibrinogen Derivatives [0.03%]
结合超分子和共价化学体系形成来源于纤维蛋白原衍生物的增强型丝状网络水凝胶
Noa Notea-Debutton,Haneen Simaan-Yameen,Dror Seliktar
Noa Notea-Debutton
Fibrin hydrogels provide a highly supportive environment for three-dimensional cell growth and morphogenesis but are limited by insufficient stability to maintain their shape and mechanical integrity. To address this limitation, we develope...
Bioactive-Loaded Detachable Crosslinked Hyaluronic Acid Microneedles: Structural Validation and Clinical Anti-Wrinkle Efficacy [0.03%]
负载生物活性成分的可分解交联透明质酸微针及其临床抗皱疗效研究
Puttikorn Pukfukdee,Supanan Ampawa,Wirada Littirak et al.
Puttikorn Pukfukdee et al.
Delivering a persistent biopolymer matrix to the superficial dermis remains a significant challenge for microneedle systems due to the inherent limitations of conventional dissolving platforms. Here, we present a detachable microneedle desi...
Tunable Sol-Gel Transition in Poloxamer Blends for Injectable Osteoarticular Applications [0.03%]
可用于注射性骨关节应用的普乐索默共混物的可调凝胶-溶胶转变
Marta Tuszynska,Joanna Skopinska-Wisniewska,Kaoutar Chattahy et al.
Marta Tuszynska et al.
Thermoresponsive poloxamers are commonly used in biomedical applications; however, their wider translational applicability depends on precisely controlling sol-gel transition behavior near body temperature while ensuring injectability and a...
Development and Evaluation of Polyvinyl Alcohol/Carboxymethyl Chitosan Hydrocolloid Incorporating Cynodon dactylon Extract and Zinc Oxide Nanoparticle for Bedsore Healing in a Wistar Rat Model [0.03%]
一种促进大鼠褥疮愈合的聚乙烯醇/羧甲基壳聚糖水胶体的开发及评价：结缕草提取物和氧化锌纳米粒子复配体系的研究
Sahar Molzemi,Sepehr Zamani,Maryam Molaei et al.
Sahar Molzemi et al.
Pressure ulcers present a serious clinical challenge due to their impaired healing processes and increased risk of infection, particularly for immobilized patients. This study aims to address the need for advanced wound dressings by develop...
Engineering Bone-Targeted LNP Delivery of Anti-Sclerostin Antibody mRNA for the Treatment of Osteoporosis [0.03%]
工程化骨靶向LNP递送抗Sclerostin抗体mRNA治疗骨质疏松症
Pengcheng Ren,Diaodiao Wang,Wenqiang Sun et al.
Pengcheng Ren et al.
Messenger RNA (mRNA) therapy represents a transformative platform in regenerative medicine, but its application to skeletal disorders remains limited by the pronounced hepatic tropism of conventional lipid nanoparticle (LNP) delivery system...
Mackenzie L Skelton,Tanvi Bhat,Ethan Yu et al.
Mackenzie L Skelton et al.
Senescent cell accumulation has been implicated in aging and fibrotic disease, which are both characterized by increased tissue stiffness. However, the direct connection between tissue mechanics and senescence induction remains disputed in ...
Biomaterial-Focused Strategies Targeting Dendritic Cells for Autoimmune Disease Treatment [0.03%]
以树突状细胞为目标的生物材料聚焦策略在自身免疫性疾病治疗中的应用
Aiswarya Venkata Suresh Kumar,Julia Babensee
Aiswarya Venkata Suresh Kumar
Autoimmune diseases encompass over 100 distinct diseases where the immune cells betray our body by attacking the tissues they are meant to protect. Even though rare, 15 million Americans are collectively affected by autoimmune diseases, a n...
Engineering Pro-Osteogenic Poly(l-Lactide-co-ε-caprolactone) Sponges Through Carbonate Apatite Integration [0.03%]
通过碳酸羟基磷灰石集成工程化促成骨聚(l-乳酸-co-ɛ-癸内酯)海绵
Zhanrui Lou,Ryo Kishida,Akira Tsuchiya et al.
Zhanrui Lou et al.
Flexible and porous sponges with high osteoconductivity have a wide range of bone healing applications. Although polymer/ceramic composite materials can serve as soft bone grafts, osteogenesis can be compromised when the ceramic surface is ...
Evaluation of Ethyl Cellulose-Ethanol Ablation in a Human-Sized 3D Construct of High-Grade Cervical Dysplasia [0.03%]
乙基纤维素-乙醇消融评价高危型宫颈上皮内瘤变三维模型的疗效
Gatha Adhikari,Alina Sharma,Kaitlin C Fogg et al.
Gatha Adhikari et al.
Current preclinical models for cervical dysplasia rely on animal systems that poorly mimic human anatomy. To address this and align with emerging initiatives to reduce animal experimentation, we developed a human-sized, 3D in vitro model of...
Mechanical Enhancement of Silk Fibroin Hydrogel Generated From Genetically-Modified Bombyx mori Cocoons and Promotes Osteogenesis [0.03%]
通过家蚕遗传改性获得的丝素蛋白水凝胶及其促骨形成性能研究
Huan-Xin He,Yu-Kai Huang,Zhi-Yang Gao et al.
Huan-Xin He et al.
Regenerated silk fibroin (RSF) from Bombyx mori is well known for its outstanding biocompatibility, biodegradability, and mechanical characteristics. Spider silk has even better strength and extensibility and is considered one of the best s...