Cellular Insights Into Proangiogenic Activation in Fibroblast and Endothelial Cells by Dual Drug-Loaded Emulsion Electrospun Nanofibers for Enhanced Tissue Regeneration [0.03%]
双药载脂质电纺纳米纤维促进成纤维细胞和内皮细胞管形成活性的细胞机制研究及其促组织修复作用
Vinayagamurthy Kalaiselvi,Babu Liya,Yalavarthi Karthika et al.
Vinayagamurthy Kalaiselvi et al.
Emulsion electrospinning is one of the versatile methods that offer high potential encapsulation and delivery of active ingredients within the fibrous scaffolds for various applications. In this study, an efficient nanofibrous core-shell bi...
Biomimetic Collagen Scaffolds Natural Cross-Linking Strategies via Transglutaminase and Methylglyoxal for Skin Repair [0.03%]
通过谷氨酰胺转胺酶和甲基糖醛的自然交联策略制备仿生胶原蛋白支架用于皮肤修复
Mina Vaez,Matthew Yen,Aiman Ali et al.
Mina Vaez et al.
Collagen-based scaffolds are widely used in tissue engineering for skin repair due to their biocompatibility and structural resemblance to extracellular matrix. However, rapid degradation and insufficient mechanical stability limit their ef...
Tyrell J Williams,Waqas Saleem,Sujeong Ahn et al.
Tyrell J Williams et al.
Granular hydrogels are attracting increasing attention for tissue engineering and regenerative medicine applications, owing to their highly tunable physical characteristics, exceptional modularity, and naturally interconnected microporosity...
Performance Evaluation of Highly Uniform Astragalus Polysaccharide/Silk Fibroin Microspheres Fabricated via Microfluidics as Biodegradable Fillers: Collagen Regeneration and Tissue Reaction [0.03%]
基于微流控技术制备的性能优良的均匀 Astragalus Polysaccharide/Silk Fibroin 复合微球作为可降解填充材料的评价：促进胶原蛋白再生及组织反应研究
Enshun Yang,Die Xie,Zongzhi Luo et al.
Enshun Yang et al.
Skin aging results from the synergistic assault of extrinsic environmental factors and intrinsic biological processes. While traditional microsphere implants promote skin rejuvenation through collagen regeneration, their clinical utility is...
Combining Supramolecular and Covalent Chemistry to Form Reinforced Fibrillar Network Hydrogels From Fibrinogen Derivatives [0.03%]
结合超分子和共价化学体系形成来源于纤维蛋白原衍生物的增强型丝状网络水凝胶
Noa Notea-Debutton,Haneen Simaan-Yameen,Dror Seliktar
Noa Notea-Debutton
Fibrin hydrogels provide a highly supportive environment for three-dimensional cell growth and morphogenesis but are limited by insufficient stability to maintain their shape and mechanical integrity. To address this limitation, we develope...
Bioactive-Loaded Detachable Crosslinked Hyaluronic Acid Microneedles: Structural Validation and Clinical Anti-Wrinkle Efficacy [0.03%]
负载生物活性成分的可分解交联透明质酸微针及其临床抗皱疗效研究
Puttikorn Pukfukdee,Supanan Ampawa,Wirada Littirak et al.
Puttikorn Pukfukdee et al.
Delivering a persistent biopolymer matrix to the superficial dermis remains a significant challenge for microneedle systems due to the inherent limitations of conventional dissolving platforms. Here, we present a detachable microneedle desi...
Tunable Sol-Gel Transition in Poloxamer Blends for Injectable Osteoarticular Applications [0.03%]
可用于注射性骨关节应用的普乐索默共混物的可调凝胶-溶胶转变
Marta Tuszynska,Joanna Skopinska-Wisniewska,Kaoutar Chattahy et al.
Marta Tuszynska et al.
Thermoresponsive poloxamers are commonly used in biomedical applications; however, their wider translational applicability depends on precisely controlling sol-gel transition behavior near body temperature while ensuring injectability and a...
Development and Evaluation of Polyvinyl Alcohol/Carboxymethyl Chitosan Hydrocolloid Incorporating Cynodon dactylon Extract and Zinc Oxide Nanoparticle for Bedsore Healing in a Wistar Rat Model [0.03%]
一种促进大鼠褥疮愈合的聚乙烯醇/羧甲基壳聚糖水胶体的开发及评价：结缕草提取物和氧化锌纳米粒子复配体系的研究
Sahar Molzemi,Sepehr Zamani,Maryam Molaei et al.
Sahar Molzemi et al.
Pressure ulcers present a serious clinical challenge due to their impaired healing processes and increased risk of infection, particularly for immobilized patients. This study aims to address the need for advanced wound dressings by develop...
Engineering Bone-Targeted LNP Delivery of Anti-Sclerostin Antibody mRNA for the Treatment of Osteoporosis [0.03%]
工程化骨靶向LNP递送抗Sclerostin抗体mRNA治疗骨质疏松症
Pengcheng Ren,Diaodiao Wang,Wenqiang Sun et al.
Pengcheng Ren et al.
Messenger RNA (mRNA) therapy represents a transformative platform in regenerative medicine, but its application to skeletal disorders remains limited by the pronounced hepatic tropism of conventional lipid nanoparticle (LNP) delivery system...
Mackenzie L Skelton,Tanvi Bhat,Ethan Yu et al.
Mackenzie L Skelton et al.
Senescent cell accumulation has been implicated in aging and fibrotic disease, which are both characterized by increased tissue stiffness. However, the direct connection between tissue mechanics and senescence induction remains disputed in ...