Biomimetic Dermatopontin-Collagen Nanocomposite for Accelerated Wound Healing and ECM Remodeling in Chronic Wound Conditions [0.03%]
用于慢性伤口条件下加速伤口愈合和细胞外基质重塑的仿生皮肤锚定蛋白-胶原纳米复合材料
Padmaja Murali,Anbuthiruselvan Solaimuthu,Purna Sai Korrapati
Padmaja Murali
Chronic cutaneous wounds are often accompanied by an extensive alteration in the standard extracellular matrix (ECM) architecture, leading to dysfunction of the resident cells and impaired healing. Conventional wound dressings often fail to...
Detachable Microneedles With Crosslinked Hyaluronic Acid as Superficial Skin Filler [0.03%]
交联透明质酸作为皮肤填充剂的可分离微针
Pattrawadee Toprangkobsin,Apasinee Teepakakorn,Supanan Ampawa et al.
Pattrawadee Toprangkobsin et al.
Crosslinking gives hyaluronic acid (HA) the ability to resist digestion by hyaluronidase; thus, crosslinked hyaluronic acid (cHA) is currently the most popular soft tissue filler. Clinically trained physicians usually administer cHA to the ...
Piezo1 Is an Early Mediator During Topography-Stimulated Osteogenic Differentiation of Bone Mesenchymal Stem Cells [0.03%]
拓扑刺激的骨髓基质细胞成骨分化的早期介导物Piezo1
Zhaojun Wu,Wenqing Hou,Jiachen Lu et al.
Zhaojun Wu et al.
Micro/nano-topographies (MNTs) of biomaterials are well-known to influence osteoblast differentiation, although the underlying mechanisms remain incompletely understood. Piezo1 is involved in mechanotransduction in various cell types, and w...
Mesenchymal Stromal Cell Chondrogenic Differentiation Induced by Continuous Stiffness Gradient in Photocrosslinkable Hydrogels [0.03%]
连续 stiffness梯度诱导的间充质基质细胞软骨分化在光交联水凝胶中
Sabrina C Mierswa,Erika E Wheeler,Ayla N Apsey et al.
Sabrina C Mierswa et al.
Chondrogenic differentiation of stem and progenitor cells is dependent on the biophysical properties of the surrounding matrix. Current biomaterials-based approaches for chondrogenesis are limited to discrete platforms, slowing our ability ...
Versatile Coating via Programmed Assembly of miR-155 Inhibitor and Endothelial Affinity Peptide [0.03%]
基于程序化组装的多功能抗炎糖肽涂层
Linsen Li,Di An,Jinhu Zhao et al.
Linsen Li et al.
Medical implants serve as pivotal therapeutic interventions for cardiovascular diseases. Nevertheless, challenges including endothelial injury, excessive smooth muscle cell migration, and inflammatory responses associated with implantation ...
Bilayer Electrospun Polyurethane Membrane With Tunable Elastomeric Properties for the Treatment of Congenital Diaphragmatic Hernia [0.03%]
用于先天性膈疝治疗的具有可调弹性性能的双层静电纺聚氨酯膜
Rodolphe Migneret,Guillaume Leks,Julie Favre et al.
Rodolphe Migneret et al.
Congenital diaphragmatic hernia is a rare condition characterized by the development of a defect in the diaphragm during early embryogenesis. For the most severe cases, when the diaphragmatic defect is large, the gap is currently closed by ...
PDGF-Releasing Hydrogels for Enhanced Proliferation of Human Nucleus Pulposus Cells [0.03%]
释放PDGF的水凝胶可增强人体椎间盘髓核细胞增殖
Takanori Fukunaga,Joseph J Pearson,Ryan Cree Miller et al.
Takanori Fukunaga et al.
Hydrogels offer a promising solution for sustained and controlled drug delivery and cell-tissue biocompatibility. In the intervertebral disc (IVD), delivering growth factors faces challenges due to the antagonistic inflammatory environment ...
Vascular Endothelial Growth Factor-Mimetic Peptide and Mitochondria-Targeted Antioxidant-Loaded Hydrogel System Improves Repair of Myocardial Infarction in Mice [0.03%]
血管内皮生长因子模拟肽和线粒体靶向抗氧化剂负载水凝胶系统改善小鼠心肌梗死修复
Qingling Xu,Xinhui Chen,Shuwei Sun et al.
Qingling Xu et al.
Myocardial infarction (MI) is a pathological state characterized by persistent ischemia of the heart. Following MI, the structural and functional remodeling of the myocardium and vasculature involves oxidative stress and mitochondrial dysfu...
A Rapid Manual Solid Phase Peptide Synthesis Method for High-Throughput Peptide Production [0.03%]
一种用于高通量肽生产的快速手动固相多肽合成方法
Clyde Overby,Brittany Abraham,Emmanuella Adjei-Sowah et al.
Clyde Overby et al.
Solid phase peptide synthesis (SPPS) techniques are critical for developing and using peptides in various biomedical applications. However, typical synthesis routes used in SPPS are either resource-intensive (e.g., with automated synthesis ...