Neurodevelopmental and Psychiatric Studies in Children and Adolescents With Neurofibromatosis Type I: A Comprehensive Scoping Review [0.03%]
I型神经纤维瘤病儿童和青少年的神经发育和精神病学研究：全面回顾性综述
Meera Chopra,Tin-Suet Joan Lee,Jacob Vorstman et al.
Meera Chopra et al.
A comprehensive synthesis of the broad range of neurodevelopmental and psychiatric manifestations in NF1 is needed to identify knowledge gaps and future directions for NF1 research. In the following scoping review, we identify and summarize...
Genetic Underpinnings of Obsessive-Compulsive Disorder With and Without Tics: Implications of Genetic Heterogeneity on Clinical Management [0.03%]
伴或不伴有抽动的强迫症的遗传基础：遗传异质性对临床治疗的启示
Jade-Jocelyne Zouki,Weng Tong Wu,Anthea Stylianakis et al.
Jade-Jocelyne Zouki et al.
The exact genetic mechanisms and link between obsessive-compulsive disorder (OCD) and tics/Tourette syndrome are not fully understood. This narrative review aims to summarize the literature examining whether the clinical phenotypes of OCD a...
COMT rs4680 and DAOA rs947267 Polymorphism Interact to Influence Cognition and Psychiatric Symptoms in Chronic Schizophrenia [0.03%]
慢性精神分裂症中COMT rs4680和DAOA rs947267多态性相互作用影响认知功能及精神病症状
Pinhong Chen,Lubin Wang,Fuqiang Wang et al.
Pinhong Chen et al.
Dopaminergic and glutamatergic dysfunction, involving genes such as COMT and DAOA, is implicated in schizophrenia. However, large-scale studies examining their interactions on cognitive and symptomatic outcomes remain scarce. COMT rs4680 an...
Alessandro Serretti,Daniel Souery,Siegfried Kasper et al.
Alessandro Serretti et al.
Schizophrenia (SCZ) genetic liability, quantified by polygenic scores (PGS), may influence clinical phenotypes in major depressive disorder (MDD). We investigated the effect of the SCZ-PGS derived from the latest SCZ genome-wide association...
Rüdin's Unpublished Family Study From the Early 1920s: "On the Inheritance of Manic-Depressive Insanity" [0.03%]
鲁道夫·鲁丁关于 manic-depressive insanity 遗传的家族研究（二十世纪二十年代未发表的手稿）
Kenneth S Kendler,Astrid Klee
Kenneth S Kendler
Ernst Rüdin, an important and controversial figure in the history of psychiatric genetics, published only one major empirical study on siblings of dementia praecox (DP) probands in 1916. He conducted a parallel study of siblings of proband...
Molecular Profiling of Genes Associated With Methylphenidate Pathway Therapy and Discovery of New Variants in Amazonian Amerindian Populations [0.03%]
与甲基苯丙胺通路治疗相关的基因分子特征及在亚马逊土著人群中的新变异发现
Aline Pasquini Santos,Tatiane Carinta de Souza,Kaio Evandro Cardoso Aguiar et al.
Aline Pasquini Santos et al.
In Attention Deficit Hyperactivity Disorder (ADHD), methylphenidate is one of the most widely used drugs, in which patient response significantly impacts prognosis. This study aimed to characterize the molecular profile of 10 genes associat...
A Systematic Review of Adverse Childhood Experiences and Epigenetic Age Acceleration in Later Adult Life Measured With Second and Third-Generation Epigenetic Clocks [0.03%]
童年不利经历与晚年表观遗传学衰老的系统评价——基于第二代和第三代表观遗传时钟的测量
Matthew Green,Laura Horsfall,Azam Saied
Matthew Green
We examined the relationship between adverse childhood experiences (ACEs) and epigenetic age acceleration (EAA) in adulthood as measured by second and third generation epigenetic clocks by performing a systematic review of the literature. T...
Functional Genomics Studies of Psychiatric Disorders in Individuals of Latin American Populations: A Scoping Review [0.03%]
拉丁美洲人群中精神疾病的功能基因组学研究：一项综述性研究
Luz M Porras,Isabelle Rodríguez-Lausell,Gabriel Iglesias-Maldonado et al.
Luz M Porras et al.
Over the past 15 years, genetic studies of psychiatric disorders have provided important insight into the contribution of both common variants of small effect, as well as rare exonic and copy number variants with large effect sizes. Genome-...
The Genetic Landscape of Kynurenine Predicts Neurovascular Pathology and Disrupted White Matter Integrity in Patients With Mood Disorders [0.03%]
血清烟酸胺乳酰化遗传景观预测情绪障碍患者的神经血管病理改变及白质完整性受损
Beatrice Bravi,Lidia Fortanyer-Uyà,Marco Paolini et al.
Beatrice Bravi et al.
Low-grade systemic inflammation is linked to cardiometabolic diseases and increased cardiovascular risk. Patients with mood disorders, such as Major Depressive Disorder (MDD) and Bipolar Disorder (BD), also show elevated cardiovascular risk...
Treg Cells Modulate Neuroinflammation and Behavioral Deficits in Autism: Evidence From MR-Based Genetic Analyses and Experimental Models [0.03%]
基于MR的遗传分析和实验模型证明调节性T细胞可调节自闭症相关神经炎症及行为异常
Zuqing Nie,Xinyi Xu,Junhao Chen et al.
Zuqing Nie et al.
Autism spectrum disorder (ASD) is a neurodevelopmental condition that is increasingly linked to immune dysfunction and neuroinflammation. Regulatory T cells (Tregs), which are crucial in maintaining immune homeostasis, have been implicated ...