Assessment of Genetic Correlations Between Tobacco or Alcohol Use and Neurodegenerative Diseases Using East Asian Genetic Ancestry Genome-Wide Association Study Results [0.03%]
利用东亚遗传谱系的全基因组关联研究结果评估烟草或酒精使用与神经退行性疾病之间的遗传相关性
Linda Wang,Wiame Belbellaj,Frida Lona-Durazo et al.
Linda Wang et al.
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent late-onset neurodegenerative diseases worldwide. Both are influenced in part by genetic factors and are currently incurable. Tobacco and alcohol, the two most comm...
Interaction of FXTAS Family History and College Degree Attainment Predicts Trajectories of Cognitive and Motor Symptoms in FMR1 Premutation Carrier Women [0.03%]
家族成员患有FXTAS病史和本科学历获得情况预测FMR1前突变携带女性认知障碍和运动功能症状的发展轨迹
Jinkuk Hong,Leann Smith DaWalt,Jessica Klusek et al.
Jinkuk Hong et al.
The present longitudinal study focuses on FMR1 premutation carrier women during midlife and early old age (n = 115). Bringing together the genetic risk factor of a family history of FXTAS and the environmental protective factor of higher ed...
A Global Prospective Harmonization Framework for Suicidality, Anhedonia, and Obsessive-Compulsive Symptoms in Psychiatric Genetic Studies: A Cross-Continental Study Within the Ancestral Population Network [0.03%]
精神病遗传研究中自杀倾向、快感缺失和强迫症状的全球协调框架：祖先人群网络中的跨洲研究
Ana M Diaz-Zuluaga,Jacey L Anderberg,Ana M Ramirez-Diaz et al.
Ana M Diaz-Zuluaga et al.
This study aims to prospectively collect harmonized, quantitative, and dimensional psychiatric phenotypes (suicidality, anhedonia, and obsessive-compulsive symptoms) and information on discrimination, stigma, and unfair treatment in up to 2...
"It's Not Deterministic and It Will Never Be Deterministic": A Qualitative Study on Stakeholder Perspectives of Polygenic Risk Score Testing for Post-Traumatic Stress Disorder [0.03%]
“它不是决定性的，也永远不会是决定性的”——关于 PTSD 多基因风险评分检测利益相关者视角的定性研究
Brandy M Fox
Brandy M Fox
Post-traumatic stress disorder (PTSD) causes significant mental and physical distress, yet only a small subset of individuals exposed to trauma develop the disorder. Scientists and clinicians are still unable to predict who will get the dis...
Genetic Risk and High Burden of Depression and Suicide in the Maya-Mestizo Population of Yucatán, México [0.03%]
遗传风险和抑郁症及自杀的高负担——墨西哥尤卡坦半岛玛雅-梅斯蒂索人种群的研究
Marta Menjivar,Erandi Bravo,Margarita Rivera-Balancan et al.
Marta Menjivar et al.
Major depression and suicide are critical public health concerns, particularly in underrepresented populations with unique genetic and sociocultural contexts. The Maya-mestizo population presents the highest suicide rates in the country but...
Expanding the Phenotype of TLK2-Related Neurodevelopmental Disorder: Longitudinal Presentation in Two Young Adult Females [0.03%]
TLK2相关神经发育障碍表型扩展：两位年轻女性的纵向表现
Alina Ivaniuk,Eva Kahn,Brendan Lanpher et al.
Alina Ivaniuk et al.
The TLK2 gene encodes a serine/threonine kinase essential for chromatin assembly. Loss-of-function heterozygous variants were recently identified as a cause of a rare neurodevelopmental disorder (TLK2-NDD) characterized by a variable spectr...
Psychiatric and Cognitive Features in Italian Women With the FMR1 Premutation: A Comprehensive Assessment Using SCID-5 and Standardized Cognitive Measures [0.03%]
意大利FMR1前突变女性的精神病学和认知特征综合评估：使用SCID-5和标准化认知量表
Federica Alice Maria Montanaro,Randi J Hagerman,Giuseppina Spano et al.
Federica Alice Maria Montanaro et al.
Women with the FMR1 premutation (PM) are at increased risk for fragile X-associated conditions (FXPAC), including cognitive and psychiatric features collectively termed fragile X-associated neuropsychiatric disorders (FXAND). This study is ...
No Discrepancy in Combined Genotype Distribution Data Between Two Related Studies of 5-HTTLPR and Posttraumatic Stress Disorder Risk [0.03%]
关于5-HTTLPR与 PTSD易感性相关的两项相关研究的联合基因型分布数据不存在差异
Pingxing Xie,Joel Gelernter
Pingxing Xie
Genome-Wide Association Study of Symptom Change Following Cognitive Behavioral Therapy for Common Mental Disorders [0.03%]
常见精神障碍认知行为疗法后症状变化的全基因组关联研究
Julia Bäckman,Olly Kravchenko,Matthew Halvorsen et al.
Julia Bäckman et al.
Cognitive behavioral therapy (CBT) is a well-established, evidence-based treatment for common mental disorders such as depression, anxiety disorders, and obsessive-compulsive disorder (OCD). However, treatment outcomes vary widely, and a su...