Pain neuroscience education intervention for patients who experience chronic musculoskeletal pain with concurrent opioid dependence: A pilot study [0.03%]
慢性肌肉骨骼疼痛伴发 opioids 依赖患者的疼痛神经教育干预研究——一项试点研究
Nicole D Windsor,Barbara S Smith
Nicole D Windsor
Objective: The objectives were to examine changes in kinesiophobia, pain self-efficacy, and knowledge of the neurophysiology of pain. We hypothesized that implementing an adapted-pain neuroscience education (a-PNE) curric...
Post-operative opioid consumption in pediatric solid organ transplant recipients: A single-site retrospective evaluation [0.03%]
儿童实体器官移植受者的术后阿片类药物消耗：一项单中心回顾性评估
Joseph C Resch,Benjamin Langworthy,Ranad Ghalban et al.
Joseph C Resch et al.
Background: There is a paucity of data depicting post-operative opioid consumption in pediatric solid organ transplant (SOT) recipients, limiting ability to perform power analyses in designing prospective trials focusing ...
Systematic review of real-world data associated with opioid scheduling and nonmedical use [0.03%]
关于阿片类药物管制与非医疗使用的真实世界数据系统评价
Suzanne K Vosburg,Taryn Dailey-Govoni,Jody L Green
Suzanne K Vosburg
Objective: In the context of increased use of buprenorphine for pain management, comparison of real-world data (RWD) on prescription opioid nonmedical use (NMU) based on their controlled substance schedule may assist prov...
Oral gabapentin versus metoclopramide for prevention of intrathecal opioid-induced pruritus [0.03%]
加巴喷丁与胃复安预防鞘内阿片类药物致瘙痒的对照研究
Douaa Galal Mohammad Mohammad Ibrahim,Marina Edwar Aziz Abd El-Shahid,Manal Mohammad Kamal Shams et al.
Douaa Galal Mohammad Mohammad Ibrahim et al.
Background: Spinal opioids are frequently coadministered with local anesthetics for analgesia, allowing the use of a lower dose of each agent, thus minimizing side effects. Most opioid-induced side effects, such as nausea...
Randomized Controlled Trial
Journal of opioid management. 2026 Jan-Feb;22(1):69-75. DOI:10.5055/jom.0928 2026
Development, optimization, and in vitro assessment of abuse-deterrent formulation [0.03%]
开发、优化和体外评价具滥用阻断作用的制剂
Jaydip Bhola,Chetan Borkhataria
Jaydip Bhola
Drug abuse and misuse have been a public health issue for many years. To curb this problem, abuse-deterrent formulations (ADFs) have been developed. The present research aimed to develop an ADF using a simple yet effective, scalable, and co...
Formulation development and a Phase 1 clinical study of PF614-MPAR, an oxycodone prodrug with oral opioid overdose protection [0.03%]
一种口服阿片类药物过量防护羟考酮前药PF614-MPAR的制剂开发及其I期临床研究
D Lynn Kirkpatrick,Linda A Pestano,Cari Evans et al.
D Lynn Kirkpatrick et al.
Introduction: Prevention of oral overdose of opioids is a critical unmet need. PF614-Multi-Pill Abuse Resistance (MPAR®) was designed to deliver desired opioid-level analgesia at therapeutic dose levels while providing o...
Clinical Trial
Journal of opioid management. 2026 Jan-Feb;22(1):37-A26. DOI:10.5055/jom.0991 2026
The past is prologue: Reconceptualizing methadone and buprenorphine for post-operative pain [0.03%]
往事如序幕：重新思考美沙酮和丁丙诺啡在术后镇痛中的应用
Thomas R Hickey,Yi Zhang,Gregory Acampora
Thomas R Hickey
Opioids remain a central element of perioperative pain management despite increased utilization of multimodal adjuvant strategies intended to reduce their use. Contemporary use of methadone and buprenorphine, both conceived as opioid analge...
Slow opioid tapering compared to continued stable opioid therapy for chronic noncancer pain: A double-blinded randomized controlled trial [0.03%]
慢性非癌症疼痛患者缓慢减量与稳定剂量的阿片类药物治疗效果对比：双盲随机对照试验
Benjamin Lai,Brandon Hidaka,Mohammad Aziz et al.
Benjamin Lai et al.
Objective: To investigate whether gradually discontinuing chronic opioid therapy (COT) affects quality of life (QOL), depression, and anxiety. Design: ...
Randomized Controlled Trial
Journal of opioid management. 2026 Jan-Feb;22(1):11-27. DOI:10.5055/jom.0969 2026
Nathan Langley,Edric Engert,Steven Passik
Nathan Langley
Timing and opioid dosage considerations before changing analgesic strategy [0.03%]
换用止痛策略之前的时机及阿片剂量考量
Pietro Buonavolontà,Maria Alfieri,Angela Cangiano et al.
Pietro Buonavolontà et al.