Copper-catalyzed generation of nitrogen-centered radicals and reactions thereof [0.03%]
铜催化生成氮自由基及其反应性研究
Sherry R Chemler
Sherry R Chemler
Nitrogen-centered radicals are reactive intermediates that can function in the formation of new C-N bonds or enable the formation of other bonds through their ability to abstract hydrogen atoms to generate carbon radical intermediates. Meth...
An efficient debromination technique using PMHS with a number of ligands containing different functional groups [0.03%]
一种高效的使用PMHS与含不同功能基团的配体进行脱溴的方法
Md Yeunus Mian,Prithu Mondal,Dishary Sharmin et al.
Md Yeunus Mian et al.
Herein is described the strategy to debrominate different aryl bromides selectively, using polymethylhydrosiloxane (PMHS) which tolerates a variety of functional groups. Key elements of this approach include the use of catalytic Pd(OAc)2 an...
Novel Conversions of a Multifunctional, Bio-sourced Lactone Carboxylic Acid [0.03%]
多功能性生物来源内酯羧酸的新转化反应
Trinadh Kaicharla,Sangjun Lee,Ruiqin Wang et al.
Trinadh Kaicharla et al.
The plant-derived compounds furfuryl alcohol and itaconic anhydride are known to undergo a Diels-Alder reaction at room temperature and in bulk to efficiently give an alkene-containing lactone carboxylic acid. Reported here is the conversio...
Exceptional reactivity of the bridgehead amine on bicyclo[1.1.1]pentane [0.03%]
桥头胺bicyclo[1.1.1]戊烷的反应性异常高
Yong Lu,Chuo Chen
Yong Lu
Bicyclo[1.1.1]pentane (BCP) has received substantial interest in the field of synthetic chemistry recently for its potential use as a benzene isostere in medicinal chemistry. Whereas bicyclo[2.2.2]octane (BCO) has also been used as a bioiso...
Synthesis and characterization of fluorescent amino acid dimethylaminoacridonylalanine [0.03%]
荧光氨基酸二甲基氨乙酰丙氨酸的合成与表征
Chloe M Jones,George A Petersson,E James Petersson
Chloe M Jones
Fluorescent amino acids are powerful biophysical tools as they can be used in structural or imaging studies of a given protein without significantly perturbing its native fold or function. Here, we have synthesized and characterized 7-(dime...
Design, synthesis and characterization of novel gamma‑aminobutyric acid type A receptor ligands [0.03%]
新型γ-氨基丁酸A型受体配体的设计、合成与表征
Kamal P Pandey,Zubair Ahmed Khan,Lalit K Golani et al.
Kamal P Pandey et al.
Antinociceptive ligand HZ-166 is a GABAA α2/α3 receptor subtype-selective potentiator. It has been shown to exhibit anxiolytic-like effects in rodent and rhesus monkeys, as well as reduced sedative/ataxic liabilities. In order to improve ...