Detection of Human Cytomegalovirus lncRNA4.9 in Breast Tumor Tissue Using RNA In Situ Hybridization [0.03%]
乳腺肿瘤组织中人巨细胞病毒lncRNA4.9的RNA原位杂交检测
Arthur Morley-Bunker,Georgia Turner,Brooke Beardsley et al.
Arthur Morley-Bunker et al.
Human cytomegalovirus (HCMV) has been linked to tumor progression in several cancers, but its role in breast cancer remains uncertain. This study investigated HCMV long non-coding RNA4.9 (lncRNA4.9) in three breast cancer subtypes (ER+/PR+,...
Immunocytochemical Localization of Neuronal Nitric Oxide Synthase (nNOS) in Neutrophils: Hydroxyurea Therapy Induced Nucleo-Cytoplasmic Translocation in Sickle Cell Disease [0.03%]
神经元型一氧化氮合酶(nNOS)在中性粒细胞中的免疫细胞定位：羟脲治疗诱导的镰状细胞病核胞浆转位
Rashmi Saini,Shilpy Shakya,Silvio Roberto Consonni
Rashmi Saini
Sickle cell disease (SCD) is an inherited hemoglobinopathy leading to the deformability of red blood cells, enhanced cellular adhesion, and blockage in microcirculation. "Sickle Neutrophils" cause oxidative stress and decreased bioavailabil...
Neutrophil Extracellular Traps Formation Adhering to Cholesterol Crystals Modulates Inflammatory Cytokines Release and Promotes Their Disruption: Insights In Situ Touch-imprints Method From Non-obstructive General Angioscopy [0.03%]
黏附胆固醇结晶的中性粒细胞胞外诱捕网的形成调控炎症因子释放并促进其崩解：非阻塞性血管内镜刮片方法的体内研究
Chikao Yutani,Nobuzo Iwa,Hirotaka Noda et al.
Chikao Yutani et al.
Both macrophages and neutrophils are recognized as innate immune cells; the former engulf cholesterol crystals (CCs) while secreting NLRP3, which also promote inflammatory responses and drive the latter into atherosclerotic plaques. Moreove...
Spatial Proteomic Profiling, a Novel Method for Detecting Diagnostic and Prognostic Proteins in Pediatric Sarcoma [0.03%]
空间蛋白质组学 profiling，一种在儿童肉瘤中检测诊断和预后蛋白的新方法
Abderrahman Ouban,Amani Alkofide,Antonello Podda et al.
Abderrahman Ouban et al.
Pediatric sarcomas comprise approximately 10% of all childhood solid malignancies and are characterized by distinct genetic and proteomic alterations that have potential diagnostic, prognostic, and therapeutic significance. We have utilized...
Expression and Spatial Localization of Glycosaminoglycan Types in Cartilage From Different Anatomical Locations [0.03%]
不同解剖位置软骨糖胺聚糖的表达及空间定位
Manula S B Rathnayake,Reimer V Wolff,Nicole Kops et al.
Manula S B Rathnayake et al.
Sulphated glycosaminoglycan (sGAG) is a major component of cartilage and known to be involved in cell signaling processes, but little is known about expression and localization in different cartilage types. Using common histochemical staini...
Aquaporin-4 Localization in Terminal Glial Cells of Human Mechanosensory Corpuscles: An Immunohistochemical Study of Penile Tissues [0.03%]
人类机械感受器 corpuscle 终末胶质细胞 Aquaporin-4 定位的免疫组化研究：取材于阴茎组织
Alfonso Cepeda-Emiliani,Tomás García-Caballero,María Otero-Alén et al.
Alfonso Cepeda-Emiliani et al.
Aquaporin-4 (AQP4), the predominant water channel in the central nervous system, has been extensively characterized in astroglia, but its presence in peripheral mechanoreceptive end-organs remains unknown. We investigated AQP4 localization ...
Seeing, Interpreting, and Trusting Images in the Age of Artificial Intelligence [0.03%]
人工智能时代的图像鉴伪及信任问题研究
Katia Cortese,Patrizio Castagnola
Katia Cortese
Artificial intelligence (AI) is transforming how cell biologists generate, analyze, and interpret visual data. Automated pipelines and large-scale image analysis increase throughput and reproducibility, yet they also modify how visual evide...
P63 and Tight Junctions Targeted for Therapy in Human Salivary Duct Adenocarcinoma Cells [0.03%]
人腮腺导管腺癌细胞中P63和紧密连接的治疗靶点
Masahiko Oyanagi,Takumi Konno,Takayuki Kohno et al.
Masahiko Oyanagi et al.
Salivary gland cancer is a rare heterogeneous group of neoplasms with complex histopathologic patterns, including carcinoma with squamous differentiation, for which surgery is the standard treatment. However, further research is essential f...
Human iPSC-Derived Blood Vessel Organoids for Studying Chronic Hypoxia-Induced Microvascular Dysfunction [0.03%]
人多能干细胞衍生的血管器官体研究慢性缺氧诱导的微血管功能障碍
Paola Serrano Martinez,Maxime Cammeraat,Amber Teppema et al.
Paola Serrano Martinez et al.
Microvascular dysfunction due to hypoxia is a key contributor in the pathogenesis of many disorders including cancer and retinal and cardiovascular diseases, but relevant human models are missing. Here, we present a robust 3D in vitro metho...
From Manual to Macro: A Reproducible Fiji Workflow for Semi-automated Collagen Fibril Diameter Quantification in Transmission Electron Microscopy [0.03%]
从手动到宏：用于透射电子显微镜半自动胶原纤维直径定量的可重复Fiji工作流
Apoorva Bhandari,Nobuyo Mizuno,Sara F Tufa et al.
Apoorva Bhandari et al.
Quantitative assessment of collagen fibril diameter is essential for understanding ultrastructural changes in aging, connective tissue disorders, and extracellular matrix remodeling. Although transmission electron microscopy (TEM) is widely...