Expression and Spatial Localization of Glycosaminoglycan Types in Cartilage From Different Anatomical Locations [0.03%]
不同解剖位置软骨糖胺聚糖的表达及空间定位
Manula S B Rathnayake,Reimer V Wolff,Nicole Kops et al.
Manula S B Rathnayake et al.
Sulphated glycosaminoglycan (sGAG) is a major component of cartilage and known to be involved in cell signaling processes, but little is known about expression and localization in different cartilage types. Using common histochemical staini...
Aquaporin-4 Localization in Terminal Glial Cells of Human Mechanosensory Corpuscles: An Immunohistochemical Study of Penile Tissues [0.03%]
人类机械感受器 corpuscle 终末胶质细胞 Aquaporin-4 定位的免疫组化研究：取材于阴茎组织
Alfonso Cepeda-Emiliani,Tomás García-Caballero,María Otero-Alén et al.
Alfonso Cepeda-Emiliani et al.
Aquaporin-4 (AQP4), the predominant water channel in the central nervous system, has been extensively characterized in astroglia, but its presence in peripheral mechanoreceptive end-organs remains unknown. We investigated AQP4 localization ...
Seeing, Interpreting, and Trusting Images in the Age of Artificial Intelligence [0.03%]
人工智能时代的图像鉴伪及信任问题研究
Katia Cortese,Patrizio Castagnola
Katia Cortese
Artificial intelligence (AI) is transforming how cell biologists generate, analyze, and interpret visual data. Automated pipelines and large-scale image analysis increase throughput and reproducibility, yet they also modify how visual evide...
P63 and Tight Junctions Targeted for Therapy in Human Salivary Duct Adenocarcinoma Cells [0.03%]
人腮腺导管腺癌细胞中P63和紧密连接的治疗靶点
Masahiko Oyanagi,Takumi Konno,Takayuki Kohno et al.
Masahiko Oyanagi et al.
Salivary gland cancer is a rare heterogeneous group of neoplasms with complex histopathologic patterns, including carcinoma with squamous differentiation, for which surgery is the standard treatment. However, further research is essential f...
Human iPSC-Derived Blood Vessel Organoids for Studying Chronic Hypoxia-Induced Microvascular Dysfunction [0.03%]
人多能干细胞衍生的血管器官体研究慢性缺氧诱导的微血管功能障碍
Paola Serrano Martinez,Maxime Cammeraat,Amber Teppema et al.
Paola Serrano Martinez et al.
Microvascular dysfunction due to hypoxia is a key contributor in the pathogenesis of many disorders including cancer and retinal and cardiovascular diseases, but relevant human models are missing. Here, we present a robust 3D in vitro metho...
From Manual to Macro: A Reproducible Fiji Workflow for Semi-automated Collagen Fibril Diameter Quantification in Transmission Electron Microscopy [0.03%]
从手动到宏：用于透射电子显微镜半自动胶原纤维直径定量的可重复Fiji工作流
Apoorva Bhandari,Nobuyo Mizuno,Sara F Tufa et al.
Apoorva Bhandari et al.
Quantitative assessment of collagen fibril diameter is essential for understanding ultrastructural changes in aging, connective tissue disorders, and extracellular matrix remodeling. Although transmission electron microscopy (TEM) is widely...
Gabriel Opoku,Kentaro Ikemura,Omer F Hatipoglu et al.
Gabriel Opoku et al.
ADAMTS1 (a disintegrin-like and metalloproteinase domain with thrombospondin type 1 repeats) is a secreted metalloproteinase with a known role in extracellular matrix remodeling in cardiovascular development and female fertility. Because of...
FGF2 Boost for Driving Forebrain Organoid Maturation Under Static Conditions [0.03%]
FGF2在静态培养条件下促进前脑类器官成熟的作用
Eleonora Grecu,Cristina Maxia,Cristina Dolciotti et al.
Eleonora Grecu et al.
Forebrain organoids (FOs) closely replicate key features of human brain, but often develop necrotic cores due to oxygen diffusion limits, resulting in disassembly. While dynamic culture devices can mitigate this, they add variability and di...
Effects of Glial Cell Line-Derived Neurotrophic Factor and Ciliary Neurotrophic Factor on Extraocular and Limb Muscle Precursor Cells [0.03%]
胶质细胞系源神经生长因子和视网膜神经营养因子对眼外肌和四肢肌前体细胞的作用
Austin J Winker,Laura L Johnson,Linda K McLoon
Austin J Winker
SummaryMyogenic precursor cells within skeletal muscles are responsible for the maintenance of skeletal muscle over a lifetime. Neurotrophic and growth factors play critical roles in this maintenance and in responses of myogenic precursor c...
Contribution of Cardiac CD34⁺ Stromal Cells to Post-Myocardial Infarction Repair in Middle-Aged Rats [0.03%]
心脏CD34⁺基质细胞在中年大鼠心肌梗死修复中的作用
Daniel T Schneider,Eduard I Dedkov
Daniel T Schneider
This study investigated the spatiotemporal dynamics of cardiac CD34⁺ stromal cells (SCs) during the reparative/proliferative phase of post-myocardial infarction (MI) healing. A transmural, non-reperfused MI was induced in middle-aged male ...