Genomics for Sudden Cardiac Death: A Review of the Topic and Call for Increased Professionalism in Clinico-Molecular Autopsy and Forensic Laboratory Sciences [0.03%]
心脏骤停的基因组学：主题回顾及临床分子尸检和法医实验室科学研究的规范化呼叫
Ivan Šoša,Consolato M Sergi
Ivan Šoša
In 2001, the first draft sequence of the human genome was released, the culmination of a decade-long, multibillion-dollar effort. Since then, an OMICs platform has been proposed to further evaluate and edit the human genome for diagnostic a...
Downregulation of PLCXD3 Promotes Gastric Cancer Cell Stemness and Invasiveness as a Potential Early Diagnostic Biomarker [0.03%]
PLCXD3表达下调通过促进胃癌干细胞特性及侵袭性可作为胃癌早期诊断的标志物
Gang Xue,Lijian He
Gang Xue
Gastric cancer (GC) is a leading cause of cancer-related death worldwide, and insufficient early diagnostic strategies limit patient outcomes. Phospholipase C X-domain containing 3 (PLCXD3) has been implicated in tumor progression, but its ...
Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation Presenting Primarily with Exercise Intolerance: A Case Report [0.03%]
以运动不耐受为主要表现的脑干脊髓型乳酸升高性白质脑病一例报告
Changhao Li,Wei Chen,Juan Du et al.
Changhao Li et al.
Objective: Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL) is a rare autosomal recessive leukodystrophy caused by pathogenic variants in the DARS2 gene. Although the clinical ph...
Case Reports
Annals of clinical and laboratory science. 2025 Nov;55(6):995-1000. DOI: 2025
Human Monoclonal Antibody against hIL18 Receptor Accessory Protein Chain Promotes Anti-Tumor Activity in Triple-Negative Breast Cancer [0.03%]
人源化抗hIL18受体辅助蛋白链单克隆抗体在三阴性乳腺癌中促进抗肿瘤作用
Fang Hu,Yonggang Wang,Guowei Qian et al.
Fang Hu et al.
Objective: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that lacks effective targeted therapies. The interleukin-18 (IL-18) signaling pathway contributes to cancer progression and poor su...
Effects of Programmed Death-Ligand 1 Expression and Clinicopathological Features on the Survival Outcomes of Patients with Colorectal Cancer: A Meta-Analysis [0.03%]
程序性死亡配体1表达和临床病理特征对结直肠癌患者生存结局的影响：一项系统评价和Meta分析
Ran Liu,Xinya Pang,Xiaohong Wang
Ran Liu
Objective: To explore the effects of programmed death-ligand 1 (PD-L1) and clinicopathological features on the outcomes of patients with colorectal cancer (CRC), and to predict their prognosis using a meta-analysis. ...
Meta-Analysis
Annals of clinical and laboratory science. 2025 Nov;55(6):964-971. DOI: 2025
Differentiation-Inducing Effects of Triciribine and All-Trans Retinoic Acid in Acute Myeloid Leukemia Cell lines [0.03%]
三环茋和全反式维甲酸诱导急性髓系白血病细胞分化的作用研究
Yuri Sato-Nagaoka,Shinichiro Takahashi
Yuri Sato-Nagaoka
Objective: To investigate the differentiation-inducing activity of triciribine (TCN), alone and in combination with all-trans retinoic acid (ATRA), in acute promyelocytic leukemia (APL) and acute myeloid leukemia (AML) ce...
Fatal Eosinophilic Pulmonary Vasculitis in a Neonate - The First Documented Case in the English Literature [0.03%]
新生儿致死性嗜酸细胞性肺血管炎首例文献报道病例
Jessica Claus,Robert Barno,Joseph M Bliss et al.
Jessica Claus et al.
Objective: This case presentation offers an in-depth exploration of the complex and multifaceted realm of neonatal eosinophilic vasculitis, an extremely rare entity that has not been reported in the English literature. On...
Case Reports
Annals of clinical and laboratory science. 2025 Nov;55(6):972-976. DOI: 2025
A Case Report of HLA 5/10 Cord Blood Cell Engraftment in a Patient with Severe β Thalassemia after Haplo-Cord Stem Cell Transplantation [0.03%]
单倍体脐血移植治疗重型β地贫1例报告
Changling Zhu,Yue Hu,Li Xu et al.
Changling Zhu et al.
β-Thalassemia major (β-TM) is an autosomal recessive genetic disorder characterized by a deficiency in the synthesis of β-globin chains, leading to reduced functional hemoglobin and life-threatening chronic anemia. Allogeneic hematopoiet...
Case Reports
Annals of clinical and laboratory science. 2025 Nov;55(6):981-987. DOI: 2025
uPAR Is Regulated via miR-561-3p and Affects the Progression and Aggressiveness of CRC Cells [0.03%]
uPAR受miR-561-3p调节并影响结直肠癌细胞的进展和侵袭性
Xi Yang,Xuelian Wang,Lu Sang
Xi Yang
Objective: Urokinase plasminogen activator (uPA), its receptor uPAR, and plasminogen activator inhibitor type 1 (PAI-1), constitute the plasminogen urokinase activation system that is thought to be associated with the mal...