Double-humanized Rats for CYP3A and PXR as an Improved Model for Analyzing Drug-drug Interactions Mediated by CYP3A4 [0.03%]
双人类化的CYP3A和PXR大鼠是分析CYP3A4介导的药物相互作用模型的有效改进模型
Kaoru Kobayashi,Genki Minegishi,Kanako Kazuki et al.
Kaoru Kobayashi et al.
The human cytochrome P450 3A4 (CYP3A4) enzyme, which is expressed in the liver and the intestines, catalyzes the metabolism of numerous drugs. The induction of CYP3A4 by the pregnane X receptor (PXR) represents a significant problem in phar...
A Nanomicelles Platform Delivery System for Water-Insoluble Corticosteroid to Treat Anterior Uveitis [0.03%]
一种用于治疗前部脉络膜炎的纳米白蛋白颗粒递送系统
Priyadarshini Sathe,Srujana Mosalikanti Sai Kameshwari,Jayabalan Nirmal
Priyadarshini Sathe
Difluprednate is marketed as an emulsion due to its poor aqueous solubility. Emulsions are known to cause ocular discomfort and require frequent dosing to show therapeutic activity. Nanomicelles are well known to improve the solubility and ...
Impact of Gastric Emptying Kinetics on Dipyridamole Dissolution Using a Gastrointestinal Simulator [0.03%]
胃排空动力学对胃肠模拟器中双嘧达莫溶解的影响
Alejandro Ruiz-Picazo,Luis Jimenez,Marta Gonzalez-Alvarez et al.
Alejandro Ruiz-Picazo et al.
Gastric emptying plays a crucial role in the dissolution and absorption of oral drugs, particularly those with pH-dependent solubility, such as dipyridamole. This study evaluates the impact of gastric emptying kinetics on dipyridamole disso...
Yiyang Chen,Yeqing Ren,Kaixin Zhou et al.
Yiyang Chen et al.
Cardiovascular diseases (CVDs) have become one of the leading threats to human health due to their high incidence and mortality rates. Their pathological mechanisms are complex, involving inflammation, oxidative stress, energy metabolism, a...
Comparison of Surrogate Models in Tablet Dissolution Prediction: Addressing the Limitations of F₂ and Introducing Sum of Ranking Differences for Model Evaluation [0.03%]
片剂溶出预测中的代理模型比较：解决F₂的局限性并引入秩和差异进行模型评估
Orsolya Péterfi,Béla Kovács,Tibor Casian et al.
Orsolya Péterfi et al.
As process analytical technology (PAT) and real-time release testing (RTRT) are gaining momentum in the pharmaceutical industry, there is an increasing need for developing methods for the non-destructive and real-time characterization of th...
Comparative Study
The AAPS journal... 2025 Jul 8;27(5):118. DOI:10.1208/s12248-025-01100-2 2025
Doxorubicin Stability-indicating Method and its Main Degradation Products In vitro Toxicity [0.03%]
多柔比星降解产物的稳定性指示方法及毒性研究
Mariah de Almeida Ultramari,Ariane Rivellis Julio,Larissa Souza Passos et al.
Mariah de Almeida Ultramari et al.
Human health and the environment are continuously impacted by anthropogenic activities, particularly those involving emerging compounds. As these compounds are newly identified or not yet fully documented in the literature, comprehensive kn...
Simplifying Pharmacokinetics, Applying it to Drug and Dosage Form Development, and Making Drug Dosage Decisions in Clinical Medicine: The Adaptation of Kirchhoff's Laws from Physics [0.03%]
化简药动学、应用于药物及制剂开发和临床医学用药决策：从物理学的基尔霍夫定律谈起
Leslie Z Benet,Jasleen K Sodhi
Leslie Z Benet
Over the past three years, we have published a series of nine manuscripts demonstrating that all relevant pharmacokinetic relationships may be simply derived independent of differential equations, offering an alternative to traditional phar...
Dissolution of Oral Solid Dosage Formulations: Surrogate Models and Real-time Release [0.03%]
口服固体制剂的溶解试验：替代方法和实时放行
Melanie Dumarey,Tessa M Carducci,Matthew J Walworth et al.
Melanie Dumarey et al.
In vitro dissolution testing is commonly performed to ensure that oral solid dosage medicines are of high quality and will achieve their targeted in vivo performance. However, this testing is time and material consuming. Therefore, pharmace...
Procedural Variation May Contribute to 6-Minute Walk Distance Variability in Real-World Pediatric Pulmonary Arterial Hypertension Study [0.03%]
流程的差异可能有助于实际儿科肺动脉高压研究中6分钟步行距离的变化
Cynthia Kleppinger,Dunbar Ivy,Norman Stockbridge et al.
Cynthia Kleppinger et al.
The six-minute walk test (6MWT) is a common method to assess submaximal exercise capacity in children and adults with pulmonary arterial hypertension (PAH) and other chronic diseases. There is no guideline specifically for 6MWT in children....
Observational Study
The AAPS journal... 2025 Jun 27;27(5):114. DOI:10.1208/s12248-025-01098-7 2025