Correction to: Considerations in Kp,uu,brain-based Strategy for Selecting CNS-targeted Drug Candidates with Sufficient Target Coverage and Substantial Pharmacodynamic Effect [0.03%]
Correction to：Kp,uu,脑策略选择中枢神经系统药物候选物的考量——充分的目标覆盖和实质性药理动力学效应
Ling Zou,Huan-Chieh Chien,Devendra Pade et al.
Ling Zou et al.
Published Erratum
The AAPS journal. 2026 May 28;28(4):111. DOI:10.1208/s12248-026-01256-5 2026
Development and Implementation of a Hinderance-based In Vitro Model for Porous Membranes [0.03%]
基于障碍的体外多孔膜模型的开发与实施
Daniel A Paterson,Lucy Coleman,Yuri Dancik et al.
Daniel A Paterson et al.
In vitro release testing (IVRT) is an inexpensive and routine step in dermal formulation development where an inert membrane separates the donor formulation from a receptor solution. Experimental IVRT data provides insights into formulation...
Exploration of Colonic Mucus as A Dissolution Compartment for Orally Administered Drugs [0.03%]
结肠黏液作为口服药物溶解池的探索研究
Mingjun Wu,Eva M Karlsson,Christel A S Bergström
Mingjun Wu
Colonic mucus has gained interest as a dissolution compartment in the large intestine due to the large fraction of bound water. Notably, the mucus layer contains more water than what is freely mobile within the colonic lumen. Here, we studi...
A Mechanistic Framework Integrating Renal QSP-PK-PD and Machine Learning for Baseline-Informed Stratification of Diuretic Resistance [0.03%]
基于基线信息的利尿剂抵抗分层的肾脏机制框架整合了QSP-PK-PD和机器学习
Jialiang Zhou,Vingyou Lou,Yixin Zhao et al.
Jialiang Zhou et al.
Diuretic resistance represents a major source of heterogeneity in loop diuretic response and remains a key barrier to effective decongestion in heart failure. A key clinical challenge is the early identification of patients at high risk of ...
HLA Class II Alleles DRB1*11:01 and DQB1*03:01 Unmask Immunogenetic Susceptibility to Anti-Nivolumab Antibodies in Combination with Ipilimumab [0.03%]
抗PD-1单抗治疗过程中发生免疫相关不良事件的易感HLA-II类等位基因DRB1*11：01和DQB1*03：01
Surendran Rajendran,Andres H Gutierrez,Ming-Shan Chien et al.
Surendran Rajendran et al.
Biologic combinations that modulate immune responses are increasingly used in oncology, enhancing anti-tumor immunity but also raising the risk of anti-drug antibody (ADA) development. Nivolumab administered in combination with ipilimumab r...
Immunogenicity Assessment for siRNA Therapeutics: A Risk-Based Proposal for Event-Driven Testing [0.03%]
siRNA药物免疫原性评估的风险为基础的事件驱动研究的设计与实施的建议
An Zhao,Sarah Bond,Valerie Clausen et al.
An Zhao et al.
Oligonucleotide therapeutics (ONTs) have emerged as a transformative treatment modality with numerous products approved globally for addressing a variety of diseases. Within this class, siRNAs therapeutics have achieved remarkable success, ...
Nanotechnology-enhanced Natural Products for Cancer Chemoprevention: Molecular Mechanisms and Clinical Translation [0.03%]
纳米技术增强的天然产物在癌症化学预防中的作用：分子机制和临床转化
Rajat Nath,Sibashish Kityania,Deepa Nath et al.
Rajat Nath et al.
Cancer remains a major global health challenge. Natural compounds, such as curcumin, resveratrol, genistein, thymoquinone, and paclitaxel, show chemopreventive activity by modulating signaling pathways, including PI3K/Akt, NF-κB, and p53. ...
Applications of Thermoresponsive Hydrogels for Sustained Drug Release in Ocular and Intravitreal Formulations Treating Visual Impairments [0.03%]
温敏水凝胶在眼科和玻璃体内给药中用于治疗视力障碍的控释药物的应用研究进展
Bayan Alshahrouri,Benjamin E Blass,Thomas Dürig et al.
Bayan Alshahrouri et al.
Vision loss is one of the most debilitating eye impairments, with the leading causes such as cataracts, glaucoma, injuries to the surface of the eye and age-related macular degeneration, significantly affecting a person's quality of life an...
In-depth Characterization of Photo-Stressed Antibody-Drug Conjugates by Mass Spectrometry [0.03%]
用于光应力抗体药物偶联物表征的质谱法
Xiao Pan,Yimeng Zhao,Shukun Luo et al.
Xiao Pan et al.
Camptothecin (CPT)-based antibody-drug conjugates (ADCs) have become popular oncology biotherapeutics that integrate the targeted specificity of monoclonal antibodies (mAbs) with camptothecin and its derivatives. Because mAbs are vulnerable...
Estimating Intragastric Disintegration Times of Immediate Release Dose Units Administered After a High-Calorie, High-Fat Meal Using Standardized, Commercially Available Equipment and Materials [0.03%]
采用标准化的商用设备和材料估算高热量、高脂肪餐后服用的即释制剂单位在胃内的崩解时间
Maria Vertzoni,Erato Androulaki,Shirin Dietrich et al.
Maria Vertzoni et al.
Intragastric disintegration times of immediate release (IR) dose units after high-calorie, high-fat meal would be useful in the assessment of drug absorption process and when considering waivers of bioequivalence assessment of non-high risk...