Biomimetic porous silicon for rationally designed combination therapy to induce immunogenic cell death [0.03%]
仿生多孔硅理性设计联合疗法诱导免疫原性细胞死亡
Silja Saarela,Emilia Happonen,Milla-Iida Laari et al.
Silja Saarela et al.
Triple negative breast cancer (TNBC) has a poor prognosis due to low response to receptor-targeted therapy and immunosuppressive tumour microenvironment. Combined chemotherapy and photothermal therapy (CHT-PTT) is promising for treating met...
Oral and edible biomaterials for anti-obesity therapeutics: Protecting and delivering bioactive compounds through the GI tract [0.03%]
用于抗肥胖药物的口服和可食用生物材料：通过胃肠道保护并输送生物活性化合物
Vetriselvan Subramaniyan,Drashti Sharma,Saidur Rahman et al.
Vetriselvan Subramaniyan et al.
The oral administration of anti-obesity therapeutic peptides and phytoactive substances faces significant challenges due to gastrointestinal instability, inadequate solubility, and limited permeability. Gastric and intestinal enzymes rapidl...
Research advances in nanomaterials for gastric cancer: Diagnosis and treatment [0.03%]
纳米材料在胃癌诊疗研究进展
Weijie Zhang,Xiangyan Zhou,Kai Ma et al.
Weijie Zhang et al.
In recent years, gastric cancer (GC) has remained a major global health challenge due to its persistently high incidence and mortality rates. Despite significant advances in diagnosis and treatment, patient outcomes remain poor, and existin...
Nuclear-targeted CRISPR/Cas delivery by using aptamer-modified polymer lipid nanoparticles [0.03%]
基于适配体修饰的聚合物脂质纳米颗粒实现核定位的CRISPR/Cas传递系统
Zichen Xu,Mohammadreza Haghighat,Niusha Shafiabady et al.
Zichen Xu et al.
Efficient nuclear delivery of CRISPR/Cas ribonucleoproteins (RNP) remains a significant hurdle for non-viral systems. To address this, we developed a polymer-lipid hybrid nanoparticle functionalized with the AS1411 aptamer, targeting nucleo...
Global research landscape of natural nanogels in biomedical applications: A two-decade bibliometric analysis of development, research hotspots and future trends [0.03%]
基于文献计量的天然纳米凝胶生物医学应用研究现状、热点及趋势分析（2000-2021）
Wenqing Shi,Xucong Huang,RunjuanYang et al.
Wenqing Shi et al.
Cancer is the leading global cause of death among multifactorial diseases. As an advanced nanomedicine delivery system, nanogels (NGs) exhibit substantial potential for targeted, controlled drug release. However, a systematic analysis of na...
Nebulized delivery of multi-modular stem cell-derived exosomes for the treatment of pulmonary fibrosis [0.03%]
用于治疗肺纤维化的多模块干细胞衍生的外泌体雾化递送
Xiaoyu Gao,Chunbin Sun,Yang Yang et al.
Xiaoyu Gao et al.
Pulmonary fibrosis (PF) is a terminal pathological manifestation of a group of lung diseases characterized by fibroblast proliferation, excessive extracellular matrix deposition, inflammatory damage, and structural destruction of lung tissu...
Yunan Gao,Xuan Ding,Baoying Yuan et al.
Yunan Gao et al.
Objective: To prepare a polydatin graphene hydrogel (PD@GO-PAA) that can be orally administered and released in the intestinal tract in a sustained manner for the treatment of intestinal radiation injury. ...
Qian Wang,Yanxia Li,Weiqi Wu et al.
Qian Wang et al.
Light responsive materials are functional materials that can undergo chemical or physical changes within or between molecules after absorbing light energy, thereby exhibiting changes in certain macroscopic properties. These changes may incl...
Quercetin-loaded nanoemulsions: A promising strategy for alleviating cerebral ischemic damage in an animal model of stroke [0.03%]
载槲皮素纳米乳液在卒中动物模型中的脑缺血损伤缓解作用研究是一项有前景的策略
Samira Vahidi,Liana Parseghian,Zinab Moradi Alvand et al.
Samira Vahidi et al.
Flavonoids and nanoemulsions have attracted researchers' attention. In this study, a novel Satureja khuzistanica essential oil loaded with quercetin nanoemulsion (SKEO/Qu NE) was designed, and its effect was investigated in a stroke model. ...
Next-generation hydrogel dressings: Cargo for peptides, genes, nucleic acids, proteins, growth factors targeting diabetic wounds [0.03%]
下一代水凝胶敷料：用于靶向糖尿病伤口的肽、基因、核酸、蛋白质和生长因子的载体
Jeet Kumar Ghosh,Jaskiran Kaur,Mohit Kumar et al.
Jeet Kumar Ghosh et al.
Diabetic wounds (DW), a serious complication of diabetes mellitus that's characterized by chronic inflammation and persistent hyperglycemia. Hence, often resulting in infection, tissue necrosis and limb amputation. The underlying causes of ...