Nuclear-targeted CRISPR/Cas delivery by using aptamer-modified polymer lipid nanoparticles
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Efficient nuclear delivery of CRISPR/Cas ribonucleoproteins (RNP) remains a significant hurdle for non-viral systems. To address this, we developed a polymer-lipid hybrid nanoparticle functionalized with the AS1411 aptamer, targeting nucleolin to facilitate nu... ...
