The blood-brain barrier and beyond: Nano-based neuropharmacology and the role of extracellular matrix [0.03%]
血脑屏障之外：基于纳米技术的神经药理学与细胞外基质的作用
Petra Henrich-Noack,Dragana Nikitovic,Monica Neagu et al.
Petra Henrich-Noack et al.
Restrained drug delivery due to the blood-brain barrier (BBB) considerably limits options for the treatment of brain pathologies. The utilization of nanoparticulate (NP) carriers has been proposed as a solution. The development strategies n...
Effective encapsulation of apomorphine into biodegradable polymeric nanoparticles through a reversible chemical bond for delivery across the blood-brain barrier [0.03%]
通过可逆化学键有效封装左美艳紫木碱进入生物可降解聚合物纳米颗粒，用于穿越血脑屏障递送
Jeremy Pang Kern Tan,Zhi Xiang Voo,Shaun Lim et al.
Jeremy Pang Kern Tan et al.
Apomorphine (AMP, used for treatment of Parkinson's disease) is susceptible to oxidation. Its oxidized products are toxic. To overcome these issues, AMP was conjugated to phenylboronic acid-functionalized polycarbonate through pH-sensitive ...
Corrigendum to "Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization" [Nanomedicine 12 (3) (2016), 745-757] [0.03%]
关于“金纳米粒子共轭Rad6抑制剂通过诱导线粒体功能障碍和PARP-1过度活化在三阴性乳腺癌细胞中诱导细胞死亡：合成与表征”的勘误修正[纳米医学学报2016，12（3），745—757]
Brittany Haynes,Yanhua Zhang,Fangchao Liu et al.
Brittany Haynes et al.
Nanoparticle-microRNA-146a-5p polyplexes ameliorate diabetic peripheral neuropathy by modulating inflammation and apoptosis [0.03%]
纳米颗粒-微小RNA-146a-5p聚复合物通过调节糖尿病外周神经病的炎症和凋亡来改善糖尿病外周神经病变
Qiong Luo,Yonghao Feng,Yangmei Xie et al.
Qiong Luo et al.
Nontoxic and nonimmunogenic nanoparticles play an increasingly important role in the application of pharmaceutical nanocarriers. The pathogenesis of diabetic peripheral neuropathy (DPN) has been extensively studied. However, the role of mic...
Novel miRNA expression in the delta opioid signaling pathway mediated cell survivability in an in vitro model of ER stress [0.03%]
新miRNA在delta阿片受体信号通路介导的内质网应激细胞存活模型中的表达
M Erfath Thanjeem Begum,Himadri Shekhaar Baul,Katari Venkatesh et al.
M Erfath Thanjeem Begum et al.
Micro RNAs (miRNAs) are small non-coding RNAs which bind to the 3'-untranslated region of a mature mRNA to induce degradation; thereby regulating gene expression. It is reported that dysregulated miRNAs involved in neurodegenerative disease...
Effects of topical methotrexate loaded gold nanoparticle in cutaneous inflammatory mouse model [0.03%]
载金纳米粒甲氨蝶呤外用在皮肤炎症动物模型中的作用研究
Ilaria Fratoddi,Luisa Benassi,Elisabetta Botti et al.
Ilaria Fratoddi et al.
Gold nanoparticles functionalized with 3-mercapto-1-propansulfonate (AuNPs-3MPS) have been prepared and loaded with Methotrexate (MTX), an immunosuppressive agent used in the systemic treatment of moderate-severe inflammatory diseases. The ...
Zinc oxide nanoparticles attenuate hepatic steatosis development in high-fat-diet fed mice through activated AMPK signaling axis [0.03%]
锌纳米粒子通过激活AMPK信号轴减轻高脂饮食小鼠肝脂肪变性的进展
Surbhi Dogra,Aditya K Kar,Khyati Girdhar et al.
Surbhi Dogra et al.
Insulin resistance is thought to be a common link between obesity and Non-Alcoholic Fatty Liver Disease (NAFLD). NAFLD has now reached epidemic status worldwide and identification of molecules or pathways as newer therapeutic strategies eit...
Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection [0.03%]
以组氨糖壳聚聚（丙交酯-乙交酯）树状分子为新型突触和记忆保护纳米粒子
Ester Aso,Isak Martinsson,Dietmar Appelhans et al.
Ester Aso et al.
Poly(propylene imine) dendrimers have been shown to be promising 3-dimensional polymers for the use in the pharmaceutical and biomedical applications. Our aims of this study were first, to synthesize a novel type of dendrimer with poly(prop...
Raman spectral signatures of urinary extracellular vesicles from diabetic patients and hyperglycemic endothelial cells as potential biomarkers in diabetes [0.03%]
糖尿病患者和高血糖内皮细胞尿液外泌体的拉曼光谱特征作为潜在生物标志物的研究
Maciej Roman,Agnieszka Kamińska,Anna Drożdż et al.
Maciej Roman et al.
Raman spectroscopy was applied to the measurement of urinary and in vitro endothelium-derived extracellular vesicles (EVs) isolated by hydrostatic filtration dialysis (HFD) method. Raman spectra obtained for urinary EVs (UEVs) showed distin...
Attachment of flagellin enhances the immunostimulatory activity of a hemagglutinin-ferritin nano-cage [0.03%]
鞭毛素偶联增强血凝素-铁蛋白纳米容器的免疫刺激活性
Emerson B Lee,Hyung-Min Jeon,Chang-Ung Kim et al.
Emerson B Lee et al.
Hemagglutinin (HA) displayed on a ferritin nano-cage has been shown to be effective in generating a potent immune response against a broad range of influenza infections. Here, we showed that conjugation of flagellin together with HA to the ...