Victor de Mello Palma,Graziela Scheuer Gomes,Vanessa Justo de Lima et al.
Victor de Mello Palma et al.
This study evaluated the efficacy of chitosan hydrogel with nanoencapsulated imiquimod 0.05% as a chemopreventive agent in an oral carcinogenesis model. Forty male rats were randomly assigned to four groups. Control (no treatment; n = 10); ...
A tumor microenvironment-responsive and mannose-mediated MnO2-based nano-delivery system for synergistic targeted chemotherapy in triple-negative breast cancer [0.03%]
一种针对三阴性乳腺癌的协同靶向化疗的响应肿瘤微环境的mannose介导的MnO2基纳米输送系统
Guanghui Mei,Hanwen Wang,Xinhua Lin et al.
Guanghui Mei et al.
Triple-negative breast cancer (TNBC) remains a formidable challenge due to its aggressive progression and the absence of established therapeutic targets. This study engineered a multifunctional, tumor microenvironment (TME)-responsive nanop...
DFO biofunctionalized CaTiO₃@CS/SF-DFO scaffolds for regulating Schwann cells and dorsal root ganglion behaviors [0.03%]
用于调节施万细胞和背根神经节行为的DFO生物功能化CaTiO₃@CS/SF-DFO支架
Junzeng Si,Xiting Yang,Tingting Li et al.
Junzeng Si et al.
Peripheral nerve injury (PNI) repair faces great hurdles. Autologous nerve grafts, the clinical gold standard, suffer from donor shortage and secondary injury, while traditional nerve conduits yield unsatisfactory regeneration. Herein, we f...
Electrospun dual flavonoid-loaded polyacrylonitrile nanofibers for accelerated diabetic wound healing via NF-κB and TNF-α modulation [0.03%]
负载双黄酮的聚丙烯氰纳米纤维加速糖尿病伤口愈合（通过NF-κB和TNF-α调节）
Ayusha O Dondulkar,Satyendra K Prasad
Ayusha O Dondulkar
Diabetic wound is marked by chronic inflammation, oxidative stress, and poor tissue regeneration, requiring novel wound dressings. In this work, electrospun nanofibers of polyacrylonitrile (PAN) loaded with apigenin and naringenin as an eff...
Jia Li,Yubo Wang,Xin Ma et al.
Jia Li et al.
Brain diseases pose a major global health challenge, with the blood-brain barrier (BBB) as the core obstacle for intracranial drug delivery. Microneedles, a minimally invasive technology, can bypass the BBB via intracranial implantation, no...
Protective effects of electrospun PVP nanofibers incorporating Polygonum cognatum extract in skin cells under hypoxic conditions: Anti-inflammatory, antioxidant, and antibacterial surface functionality [0.03%]
载Polygonum cognatum提取物的PVP纳米纤维膜促进低氧皮肤修复的保护作用：抗炎抗氧化及抗菌功能研究
Sinem Gultekin Tosun,Yener Ozel,Mustafa Burak Coban et al.
Sinem Gultekin Tosun et al.
In this study, PVP nanofibers loaded with Polygonum cognatum (madimak) extract (PVP-F + ME) and pure PVP nanofibers (PVP-F) were developed to evaluate their biological effects on HDFa cells under a CoCl₂-induced hypoxia-like model. The nan...
Mitochondrial preservation underlies the antioxidant activity of nanoceria particles in light-induced retinal degeneration [0.03%]
纳米级氧化铈颗粒通过维持线粒体功能发挥抗氧化作用从而抑制光照诱导的视网膜退行性变
Darin Zerti,Luigi Donato,Ignacio Babiloni Chust et al.
Darin Zerti et al.
Age-related Macular Degeneration (AMD), the leading cause of blindness worldwide, is a multifactorial disease with mitochondrial dysfunction recognized as an early pathogenic event. In our preclinical studies, we demonstrated that a single ...
Nose-to-brain delivery of an amyloid beta blocking peptide using polylactic acid-poloxamer 188 nanocarriers [0.03%]
使用聚乳酸-泊洛沙姆188纳米载体将阻断淀粉样蛋白β肽的药物从鼻部递送至大脑
Marie Bolon,Audrey Barbereau,Mélanie Aimard et al.
Marie Bolon et al.
Background: Alzheimer's disease, characterized by a progressive cognitive decline, represents a major global health challenge. A novel blocking peptide (seq: KRKKSRYKSWSVYVG) which binds with high affinity for toxic amylo...
Nanomedicine strategies against multidrug-resistant Acinetobacter baumannii: Delivery, biofilm disruption, and translational considerations [0.03%]
用于对抗多重耐药鲍曼不动杆菌的纳米医学策略：输送、生物被膜破坏及转化方面的考量
Abida Khan,Hayat Ali Alzahrani,Tahrir Alenezi et al.
Abida Khan et al.
Acinetobacter baumannii has become a high-priority global problem because it causes hospital-acquired infections and ventilator-associated pneumonia, and multidrug resistance, environmental survivability, and biofilm formation severely rest...
Cyclodextrin-stabilized silver and gold nanoparticles induce radiosensitization of MDA-MB-231 and MCF7 breast cancer cells [0.03%]
环糊精稳定型银纳米颗粒和金纳米粒子可使MDA-MB-231及MCF7乳腺癌细胞放射增敏
M V Pustovalova,V D Nekrasov,E G Kontareva et al.
M V Pustovalova et al.
Nanomedicine highlights nanoparticles as a promising approach to improve radiation therapy, especially for breast cancer. This research investigates the impact of silver and gold nanoparticles stabilized with β-cyclodextrin (Ag-CD and Au-C...