Nanobiotics to tackle efflux-mediated resistance in bacterial pathogens [0.03%]
用于对付细菌病原体外排介导耐药性的纳米抗生素
Barani Devi Thillai,Sudarshan Kini,Vijaya Kumar Deekshit
Barani Devi Thillai
Efflux-mediated resistance is a critical mechanism by which bacterial pathogens evade antibiotic treatment, posing significant challenges to effective infection management. As the first line of defence mechanism in bacteria, efflux pumps ac...
Elucidating the multifaceted antibacterial mechanisms of luteolin: insights, challenges, and prospects for clinical translation [0.03%]
阐明黄芩素抗菌机制的多面性：见解、挑战及临床转化前景
Kushagra Khanna,Mogana Rajagopal,Pankaj Kumar et al.
Kushagra Khanna et al.
Novel antibacterial agents are critically needed in light of the constant menace posed by bacterial infections and subsequent emergence of antibiotic-resistant strains. Quality of life has been improved remarkably through antibiotics that h...
Insight into the multifactorial effect of climate change on marine bacteria: resilience mechanisms and mitigation strategies [0.03%]
气候变化对海洋细菌的多因子影响：应对机制和缓解策略的见解
Sonalin Rath,Sourav Kumar Panda,Surajit Das
Sonalin Rath
Industrialization marked a significant turning point that impacted the global climate at an unprecedented scale. Oceans, covering 71% of the surface of Earth, play a pivotal role in regulating climate change factors, serving as essential co...
Role of the NLRP3 inflammasome in the immunopathogenesis of flaviviruses [0.03%]
NLRP3炎性小体在黄病毒免疫病理中的作用
Mario A Cuapa-González,Luis Márquez-Domínguez,Paulina Cortés-Hernández et al.
Mario A Cuapa-González et al.
The Flaviviridae family includes many medically relevant members, such as dengue, Zika, West Nile, and hepatitis C viruses, that produce hundreds of millions of infections annually. There is a close relationship between these infections and...
Bifidobacterial biofilms as next-generation probiotics and their role in intestinal microbiocenosis [0.03%]
双歧杆菌菌膜作为下一代益生菌及其在肠微生物组中的作用
Kanwal Aziz,Arsalan Haseeb Zaidi
Kanwal Aziz
Many consider the gut microbiota an organ of the human body; although the view is controversial, its effect on overall human health cannot be denied. The mucosal gut bacteria are physiologically distinct from those inhabiting the gut lumen ...
How force drives pathogenicity: mechanoregulation of Streptococcus mutans adhesion to collagen [0.03%]
力引发的致病性：力调节变异链球菌黏附到胶原蛋白上
Carla Inostroza,Pablo Berríos,Ivana Orellana et al.
Carla Inostroza et al.
Streptococcus mutans is a caries-associated bacterium with the ability to adhere to the surface of oral tissues and promote biofilm formation. For this purpose, S. mutans expresses a range of specialized surface adhesins, among which collag...
Revisiting the antimicrobial potential of metalloporphyrins: from food to pharma [0.03%]
金属卟啉的抗菌潜力再探：从食品到医药
Igori Balta,Marta Žogota,Nicolae Corcionivoschi et al.
Igori Balta et al.
Porphyrins, their derivatives, and metal ion complexes - particularly copper-substituted forms such as Cu-Chl, Cu-Chln, and Na-Cu-Chln - are increasingly recognized for their broad-spectrum antimicrobial properties. However, in the context ...
Mycobacterium avium biofilms: mechanism of production, composition, and its role in pathogenesis and drug resistance [0.03%]
鸟分支杆菌生物被膜：形成机制、组成及致病性和耐药性的作用
William R McManus,Katie Mulvey,Jeffrey S Schorey
William R McManus
The genus Mycobacterium contains over 180 species, and new species are added frequently. Among these are several obligate pathogens, namely Mycobacterium leprae and the species of the Mycobacterium tuberculosis complex; however, the vast ma...
Helicobacter pylori's secret resilience: coccoid forms, yeast havens, and outer membrane vesicle release for survival and spread [0.03%]
幽门螺旋杆菌的生存秘密：椭圆体形态、酵母避难所和外膜囊泡释放助力存活与传播
Elmira Ramezani,Zahra Sadeghloo,Mehdi Azizmohammad Looha et al.
Elmira Ramezani et al.
Helicobacter pylori is globally recognized for its role in chronic gastritis, peptic ulcer disease, and gastric cancer. Yet despite decades of research and standardized eradication protocols, treatment failures and disease recurrence remain...
Anti-virulence peptides: a compromising strategy to treat Staphylococcus aureus chronic wound infection [0.03%]
抗菌毒力肽：治疗金黄色葡萄球菌慢性伤口感染的新策略
Riham Daher,Cassandra Pouget,Jean-Philippe Lavigne et al.
Riham Daher et al.
Chronic wound infections, particularly those associated with Staphylococcus aureus (S. aureus), present a significant clinical challenge due to biofilm formation and increasing antibiotic resistance. This review explores the emerging role o...