The leucine-responsive regulatory proteins/feast-famine regulatory proteins: an ancient and complex class of transcriptional regulators in bacteria and archaea [0.03%]
响应亮氨酸的调节蛋白/丰歉调节蛋白：细菌和古菌中一类古老的转录调控因子类群
Christine A Ziegler,Peter L Freddolino
Christine A Ziegler
Since the discovery of the Escherichia coli leucine-responsive regulatory protein (Lrp) almost 50 years ago, hundreds of Lrp homologs have been discovered, occurring in 45% of sequenced bacteria and almost all sequenced archaea. Lrp-like pr...
Miro proteins connect mitochondrial function and intercellular transport [0.03%]
Miro蛋白连接线粒体功能与细胞间运输
Zuzana Nahacka,Renata Zobalova,Maria Dubisova et al.
Zuzana Nahacka et al.
Mitochondria are organelles present in most eukaryotic cells, where they play major and multifaceted roles. The classical notion of the main mitochondrial function as the powerhouse of the cell per se has been complemented by recent discove...
Cancer cells dysregulate PI3K/AKT/mTOR pathway activation to ensure their survival and proliferation: mimicking them is a smart strategy of gammaherpesviruses [0.03%]
癌细胞通过调控PI3K / AKT / mTOR通路活化来确保其存活和增殖：γ-疱疹病毒模仿它们是一种聪明的策略
Mara Cirone
Mara Cirone
The serine/threonine kinase mammalian target of rapamycin (mTOR) is the catalytic subunit of two complexes, mTORC1 and mTORC2, which have common and distinct subunits that mediate separate and overlapping functions. mTORC1 is activated by p...
Claudia V Pereira,Bryan L Gitschlag,Maulik R Patel
Claudia V Pereira
Heteroplasmy refers to the coexistence of more than one variant of the mitochondrial genome (mtDNA). Mutated or partially deleted mtDNAs can induce chronic metabolic impairment and cause mitochondrial diseases when their heteroplasmy levels...
Katherine L Moran,Yelyzaveta Shlyakhtina,Maximiliano M Portal
Katherine L Moran
The evolution of organisms has been a subject of paramount debate for hundreds of years and though major advances in the field have been made, the precise mechanisms underlying evolutionary processes remain fragmentary. Strikingly, the majo...
How can a traffic light properly work if it is always green? The paradox of CK2 signaling [0.03%]
信号传导中的一种悖论：CK2信号通路总是激活会怎样？
Christian Borgo,Claudio D&#x;Amore,Luca Cesaro et al.
Christian Borgo et al.
CK2 is a constitutively active protein kinase that assuring a constant level of phosphorylation to its numerous substrates supports many of the most important biological functions. Nevertheless, its activity has to be controlled and adjuste...
SMART approaches for genome-wide analyses of skeletal muscle stem and niche cells [0.03%]
用于解析骨骼肌干细胞和生态位细胞的全基因组分析的SMART方法
Darren M Blackburn,Felicia Lazure,Vahab D Soleimani
Darren M Blackburn
Muscle stem cells (MuSCs) also called satellite cells are the building blocks of skeletal muscle, the largest tissue in the human body which is formed primarily of myofibers. While MuSCs are the principal cells that directly contribute to t...
ETF dehydrogenase advances in molecular genetics and impact on treatment [0.03%]
分子遗传学中ETFDH脱氢酶的进展及其对治疗的影响
Sara Missaglia,Daniela Tavian,Corrado Angelini
Sara Missaglia
Electron transfer flavoprotein dehydrogenase, also called ETF-ubiquinone oxidoreductase (ETF-QO), is a protein localized in the inner membrane of mitochondria, playing a central role in the electron-transfer system. Indeed, ETF-QO mediates ...
Sweet systems: technologies for glycomic analysis and their integration into systems biology [0.03%]
甜蜜的系统：糖组分析技术及其在系统生物学中的整合
Shuhui Chen,Rui Qin,Lara K Mahal
Shuhui Chen
Found in virtually every organism, glycans are essential molecules that play important roles in almost every aspect of biology. The composition of glycome, the repertoire of glycans in an organism or a biological sample, is often found alte...
A local regulatory network in the testis mediated by laminin and collagen fragments that supports spermatogenesis [0.03%]
一个由层粘连蛋白和胶原片段介导的促进精子发生的睾丸局部调控网络
Linxi Li,Huitao Li,Lingling Wang et al.
Linxi Li et al.
It is almost five decades since the discovery of the hypothalamic-pituitary-testicular axis. This refers to the hormonal axis that connects the hypothalamus, pituitary gland and testes, which in turn, regulates the production of spermatozoa...