Ribonucleotide errors, RNase HII, and ribonucleotide excision repair [0.03%]
核糖核苷酸错配、RNase HII和核糖核苷酸切除修复
Julianna R Cresti,Lyle A Simmons
Julianna R Cresti
Replicative DNA polymerases are responsible for the high-fidelity duplication of genomes in all organisms. The overall DNA replication process is highly accurate, with deoxyribonucleoside monophosphate (dNMP) errors occurring on the order o...
Secondary metabolism in Irpex lacteus (Fr.) Fr.: biosynthetic logic and redox integration [0.03%]
Irpiopsis乳糖菌次生代谢：生物合成逻辑和氧化还原整合
Yuxin Yang,Yue Wang,Chengwei Liu
Yuxin Yang
Irpex lacteus is a metabolically versatile white-rot fungus capable of producing a wide range of structurally diverse secondary metabolites, including terpenoids, phenolics, steroids, peptides, and polysaccharides. Many of these compounds e...
Olga S Sokolova,Ekaterina Kravchuk,Elizaveta Trifonova et al.
Olga S Sokolova et al.
Biochemistry has a strong interest in ion channels, a diverse group of membrane proteins. This group has long remained difficult to study at the structural level, but much progress has been made in recent decades with improvements in bioche...
DNA polymerase I: structure, activity, and function in bacterial DNA replication and repair [0.03%]
大肠杆菌DNA聚合酶I的结构、活性及其在DNA复制和修复中的功能
Frances Caroline Lowder,Lyle A Simmons
Frances Caroline Lowder
Faithful replication and repair of the genome are essential processes for all life. Genome maintenance is coordinated by a complex suite of proteins, with bacteria evolving intricate systems despite their relatively simplistic genomes. DNA ...
Mahmoud M Yaseen,Nizar M Abuharfeil,Homa Darmani
Mahmoud M Yaseen
Human immunodeficiency virus type 1 (HIV-1) negative factor (Nef) is a multifunctional accessory protein that plays a central role in HIV-1 immunopathogenesis by compromising CD4+ T cell integrity and disrupting immune homeostasis. Although...
Recent insights into bacterial ESCRT-III-mediated membrane remodeling [0.03%]
近期细菌ESCRT-III介导的膜重塑研究进展
Samuel Herianto,Hsiung-Lin Tu
Samuel Herianto
The ESCRT-III complex is a highly conserved membrane remodeling system known for its essential roles in eukaryotic cellular processes such as endosomal trafficking, multivesicular body (MVB) formation, viral budding, membrane repair, and cy...
CRISPR-Cas9 editing of agricultural crops and medicinal plants: toward a cornucopia of natural products [0.03%]
CRISPR-Cas9基因编辑在农作物和药用植物中的应用：迈向天然产物的丰收时代
Kathleen Hefferon,Srividhya Venkataraman,Anshu Alok et al.
Kathleen Hefferon et al.
Plants have been a part of human health since our very beginnings, and many of our modern pharmaceuticals claim their origins from medicinal plants. The range of specialized metabolites synthesized by plants is highly diverse, and metabolic...
Qi Cao,Yuange Duan
Qi Cao
More than 170 distinct RNA modifications have been identified, playing pivotal roles in regulating development, homeostasis, and adaptive evolution. A recent groundbreaking study in Nature revealed that glycoRNA prevents endogenous RNA from...
Ubiquitin and SUMO pathways in DNA replication and replication-coupled repair [0.03%]
泛素和SUMO途径在DNA复制及随复制进行的修复中的作用
Lidia M Fiedorowicz,Ryan M Baxley,Eric A Hendrickson et al.
Lidia M Fiedorowicz et al.
Accurate and efficient DNA replication constitutes the most effective safeguard against genome instability. Numerous aspects of replication initiation, elongation, and termination are tightly regulated by post-translational modifications. I...
Galectins: a promising arsenal of novel immunotherapeutic weapons in oncology tunned by an array of non-coding RNAs [0.03%]
糖蛋白凝集素：由一系列非编码RNA调控的新型免疫治疗武器在肿瘤学中的应用展望
Alyaa Dawoud,Tasneem Abaza,Yomna Youssef et al.
Alyaa Dawoud et al.
Galectins, a family of sugar-binding proteins, play a multifaceted role in human health and disease. They do not only regulate cellular processes but also influence tumor development and progression by promoting tumor growth, angiogenesis, ...