Amy J Fernandez,James M Berger
Amy J Fernandez
Ring-shaped hexameric helicases are essential motor proteins that separate duplex nucleic acid strands for DNA replication, recombination, and transcriptional regulation. Two evolutionarily distinct lineages of these enzymes, predicated on ...
Ita Gruic-Sovulj,Liam M Longo,Jagoda Jabłońska et al.
Ita Gruic-Sovulj et al.
Among the enzyme lineages that undoubtedly emerged prior to the last universal common ancestor is the so-called HUP, which includes Class I aminoacyl tRNA synthetases (AARSs) as well as enzymes mediating NAD, FAD, and CoA biosynthesis. Here...
The amyloid proteome: a systematic review and proposal of a protein classification system [0.03%]
淀粉样蛋白组学：系统综述及蛋白质分类系统的提议
Juliane Gottwald,Christoph Röcken
Juliane Gottwald
Amyloidosis is a disease caused by pathological fibril aggregation and deposition of proteins in different tissues and organs. Thirty-six fibril-forming proteins have been identified. So far, proteomic evaluation of amyloid focused on the d...
Jörn Glökler,Theam Soon Lim,Jeunice Ida et al.
Jörn Glökler et al.
The introduction of nucleic acid amplification techniques has revolutionized the field of medical diagnostics in the last decade. The advent of PCR catalyzed the increasing application of DNA, not just for molecular cloning but also for mol...
Conor J Howard,Adam Frost
Conor J Howard
Translation is the set of mechanisms by which ribosomes decode genetic messages as they synthesize polypeptides of a defined amino acid sequence. While the ribosome has been honed by evolution for high-fidelity translation, errors are inevi...
Mechanisms linking endoplasmic reticulum (ER) stress and microRNAs to adipose tissue dysfunction in obesity [0.03%]
内质网(ER)应激和microRNA与肥胖相关脂肪组织功能障碍之间的机制联系
Kalhara R Menikdiwela,João Pedro Tôrres Guimarães,Latha Ramalingam et al.
Kalhara R Menikdiwela et al.
Over accumulation of lipids in adipose tissue disrupts metabolic homeostasis by affecting cellular processes. Endoplasmic reticulum (ER) stress is one such process affected by obesity. Biochemical and physiological alterations in adipose ti...
Anouk G Groenen,Benedek Halmos,Alan R Tall et al.
Anouk G Groenen et al.
Plasma levels of high-density lipoprotein (HDL) inversely correlate with the incidence of cardiovascular diseases (CVD). The causal relationship between plasma HDL-cholesterol levels and CVD has been called into question by Mendelian random...
Matthew Wong,Abinaya Badri,Christopher Gasparis et al.
Matthew Wong et al.
There is an increasing demand for bioproducts produced by metabolically engineered microbes, such as pharmaceuticals, biofuels, biochemicals and other high value compounds. In order to meet this demand, modular optimization, the optimizing ...
Shruti Mishra,Swathi Kota,Reema Chaudhary et al.
Shruti Mishra et al.
The role of guanine quadruplexes (G4) in fundamental biological processes like DNA replication, transcription, translation and telomere maintenance is recognized. G4 structure dynamics is regulated by G4 structure binding proteins and is th...
Novel insights into the mechanism of cell cycle kinases Mec1(ATR) and Tel1(ATM) [0.03%]
对细胞周期激酶Mec1(ATR)和Tel1(ATM)机制的新认识
Elias A Tannous,Peter M Burgers
Elias A Tannous
DNA replication is a highly precise process which usually functions in a perfect rhythm with cell cycle progression. However, cells are constantly faced with various kinds of obstacles such as blocks in DNA replication, lack of availability...