The mechanisms of human lymphoid chromosomal translocations and their medical relevance [0.03%]
人类淋巴染色体易位的机制及其医疗相关性
Di Liu,Michael R Lieber
Di Liu
The most common human lymphoid chromosomal translocations involve concurrent failures of the recombination activating gene (RAG) complex and Activation-Induced Deaminase (AID). These are two enzymes that are normally expressed for purposes ...
Translation complex stabilization on messenger RNA and footprint profiling to study the RNA responses and dynamics of protein biosynthesis in the cells [0.03%]
复杂翻译稳定在信使RNA和足迹分析研究细胞中的RNA反应和蛋白质生物合成的动力学
Nikolay E Shirokikh
Nikolay E Shirokikh
During protein biosynthesis, ribosomes bind to messenger (m)RNA, locate its protein-coding information, and translate the nucleotide triplets sequentially as codons into the corresponding sequence of amino acids, forming proteins. Non-codin...
José López-Barneo,Patricia Ortega-Sáenz
José López-Barneo
Oxygen (O2) is essential for life and therefore the supply of sufficient O2 to the tissues is a major physiological challenge. In mammals, a deficit of O2 (hypoxia) triggers rapid cardiorespiratory reflexes (e.g. hyperventilation and increa...
The AAA+ superfamily: a review of the structural and mechanistic principles of these molecular machines [0.03%]
AAA+超家族：这些分子机器结构和机理原则的回顾
Yousuf A Khan,K Ian White,Axel T Brunger
Yousuf A Khan
ATPases associated with diverse cellular activities (AAA+ proteins) are a superfamily of proteins found throughout all domains of life. The hallmark of this family is a conserved AAA+ domain responsible for a diverse range of cellular activ...
Causes and consequences of impaired methionine synthase activity in acquired and inherited disorders of vitamin B12 metabolism [0.03%]
获得性和遗传性维生素B12代谢障碍中甲硫氨酸合成酶活性受损的原因和后果
Jean-Louis Guéant,Rosa-Maria Guéant-Rodriguez,Viola J Kosgei et al.
Jean-Louis Guéant et al.
Methyl-Cobalamin (Cbl) derives from dietary vitamin B12 and acts as a cofactor of methionine synthase (MS) in mammals. MS encoded by MTR catalyzes the remethylation of homocysteine to generate methionine and tetrahydrofolate, which fuel met...
Khadija D Wilson,Elizabeth G Porter,Benjamin A Garcia
Khadija D Wilson
The etiology of neurodevelopmental disorders (NDDs) remains a challenge for researchers. Human brain development is tightly regulated and sensitive to cellular alterations caused by endogenous or exogenous factors. Intriguingly, the surge o...
Diverse triterpene skeletons are derived from the expansion and divergent evolution of 2,3-oxidosqualene cyclases in plants [0.03%]
植物中2,3-氧化角鲨烯环化酶的扩展及分歧演化衍生出多种三萜骨架结构
Jing Wang,Yanhong Guo,Xue Yin et al.
Jing Wang et al.
Triterpenoids are one of the largest groups of secondary metabolites and exhibit diverse structures, which are derived from C30 skeletons that are biosynthesized via the isoprenoid pathway by cyclization of 2,3-oxidosqualene. Triterpenoids ...
Bijoy K Mohanty,Sidney R Kushner
Bijoy K Mohanty
Detailed studies of the Gram-negative model bacterium, Escherichia coli, have demonstrated that post-transcriptional events exert important and possibly greater control over gene regulation than transcription initiation or effective transla...
Regulation of protein function and degradation by heme, heme responsive motifs, and CO [0.03%]
血红素、血红素反应基序和一氧化碳对蛋白质功能和降解的调控
Angela S Fleischhacker,Anindita Sarkar,Liu Liu et al.
Angela S Fleischhacker et al.
Heme is an essential biomolecule and cofactor involved in a myriad of biological processes. In this review, we focus on how heme binding to heme regulatory motifs (HRMs), catalytic sites, and gas signaling molecules as well as how changes i...
Biosynthesis and trafficking of heme o and heme a: new structural insights and their implications for reaction mechanisms and prenylated heme transfer [0.03%]
血红素O和血红素A的生物合成与运输：新的结构见解及其对反应机制和异戊二烯化血红素转运的影响
Elise D Rivett,Lim Heo,Michael Feig et al.
Elise D Rivett et al.
Aerobic respiration is a key energy-producing pathway in many prokaryotes and virtually all eukaryotes. The final step of aerobic respiration is most commonly catalyzed by heme-copper oxidases embedded in the cytoplasmic or mitochondrial me...