Shramana Chatterjee,Robert P Hausinger
Shramana Chatterjee
Sulfur is an essential element for a variety of cellular constituents in all living organisms and adds considerable functionality to a wide range of biomolecules. The pathways for incorporating sulfur into central metabolites of the cell su...
Creation and resolution of non-B-DNA structural impediments during replication [0.03%]
复制过程中非B-DNA结构障碍的产生与解决
Christopher Mellor,Consuelo Perez,Julian E Sale
Christopher Mellor
During replication, folding of the DNA template into non-B-form secondary structures provides one of the most abundant impediments to the smooth progression of the replisome. The core replisome collaborates with multiple accessory factors t...
Energetics, kinetics, and pathways of SNARE assembly in membrane fusion [0.03%]
关于膜融合中SNARE组装的自由能、动力学和路径的研究
Yongli Zhang,Lu Ma,Huan Bao
Yongli Zhang
Fusion of transmitter-containing vesicles with plasma membranes at the synaptic and neuromuscular junctions mediates neurotransmission and muscle contractions, respectively, thereby underlying all thoughts and actions. The fusion process is...
Elenaé Vázquez-Ulloa,Kai-Lan Lin,Marcela Lizano et al.
Elenaé Vázquez-Ulloa et al.
The Notch signaling pathway is a direct cell-cell communication system involved in a wide variety of biological processes, and its disruption is observed in several pathologies. The pathway is comprised of a ligand-expressing (sender) cell ...
Ansgar B Siemer
Ansgar B Siemer
Although first described in the context of disease, cross-β (amyloid) fibrils have also been found as functional entities in all kingdoms of life. However, what are the specific properties of the cross-β fibril motif that convey biologica...
Hypoxia-regulated microRNAs: the molecular drivers of tumor progression [0.03%]
缺氧调控的microRNA：肿瘤进展的分子驱动因素
Sakunie Sawai,Pooi-Fong Wong,Thamil Selvee Ramasamy
Sakunie Sawai
Hypoxia is a common feature of the tumor microenvironment (TME) of nearly all solid tumors, leading to therapeutic failure. The changes in stiffness of the extracellular matrix (ECM), pH gradients, and chemical balance that contribute to mu...
Wenya Hou,Yan Li,Jiaxin Zhang et al.
Wenya Hou et al.
Cohesin, a four-subunit ring comprising SMC1, SMC3, RAD21 and SA1/2, tethers sister chromatids by DNA replication-coupled cohesion (RC-cohesion) to guarantee correct chromosome segregation during cell proliferation. Postreplicative cohesion...
Unraveling the complex regulatory networks in biofilm formation in bacteria and relevance of biofilms in environmental remediation [0.03%]
细菌生物被膜形成复杂调控网络的解析及其在环境治理中的意义
Kumari Uma Mahto,Swetambari Kumari,Surajit Das
Kumari Uma Mahto
Biofilms are assemblages of bacteria embedded within a matrix of extracellular polymeric substances (EPS) attached to a substratum. The process of biofilm formation is a complex phenomenon regulated by the intracellular and intercellular si...
Structure and function of ClpXP, a AAA+ proteolytic machine powered by probabilistic ATP hydrolysis [0.03%]
ClpXP的结构与功能研究：一种由概率水解ATP驱动的AAA+蛋白酶体
Robert T Sauer,Xue Fei,Tristan A Bell et al.
Robert T Sauer et al.
ClpXP is an archetypical AAA+ protease, consisting of ClpX and ClpP. ClpX is an ATP-dependent protein unfoldase and polypeptide translocase, whereas ClpP is a self-compartmentalized peptidase. ClpXP is currently the only AAA+ protease for w...
Emily R Garnett,Ronald T Raines
Emily R Garnett
Pancreatic-type ribonucleases (ptRNases) are a large family of vertebrate-specific secretory endoribonucleases. These enzymes catalyze the degradation of many RNA substrates and thereby mediate a variety of biological functions. Though the ...