Platelet protein synthesis, regulation, and post-translational modifications: mechanics and function [0.03%]
血小板蛋白质合成、调控和翻译后修饰：机制与功能
Gerald Soslau
Gerald Soslau
Dogma had been firmly entrenched in the minds of the scientific community that the anucleate mammalian platelet was incapable of protein biosynthesis since their identification in the late 1880s. These beliefs were not challenged until the ...
Protein aggregation-inhibition: a therapeutic route from Parkinson's disease to sickle cell anemia [0.03%]
蛋白聚集抑制：从帕金森病到镰状细胞贫血的治疗之路
Gabriel F Martins,N Galamba
Gabriel F Martins
Protein aggregation is implicated in multiple diseases, so-called proteinopathies, ranging from neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease (PD) to type 2 diabetes mellitus and sickle cell disease (SCD). ...
The tricarboxylic acid (TCA) cycle: a malleable metabolic network to counter cellular stress [0.03%]
灵活的三羧酸循环代谢网络对抗细胞压力
Alex MacLean,Felix Legendre,Vasu D Appanna
Alex MacLean
The tricarboxylic acid (TCA) cycle is a primordial metabolic pathway that is conserved from bacteria to humans. Although this network is often viewed primarily as an energy producing engine fueling ATP synthesis via oxidative phosphorylatio...
Distinct enzymatic strategies for de novo generation of disulfide bonds in membranes [0.03%]
脱辅基蛋白生成膜二硫化物的独特酶促策略
Weikai Li
Weikai Li
Disulfide bond formation is a catalyzed reaction essential for the folding and stability of proteins in the secretory pathway. In prokaryotes, disulfide bonds are generated by DsbB or VKOR homologs that couple the oxidation of a cysteine pa...
G-quadruplexes in bacteria: insights into the regulatory roles and interacting proteins of non-canonical nucleic acid structures [0.03%]
细菌中的G-四链体：非经典核酸结构的调控作用及互作蛋白质研究新进展
Rachel R Cueny,Sarah D McMillan,James L Keck
Rachel R Cueny
G-quadruplexes (G4s) are highly stable, non-canonical DNA or RNA structures that can form in guanine-rich stretches of nucleic acids. G4-forming sequences have been found in all domains of life, and proteins that bind and/or resolve G4s hav...
2-5A-Mediated decay (2-5AMD): from antiviral defense to control of host RNA [0.03%]
由2-5A介导的降解(2-5AMD)：从抗病毒防御到宿主RNA调控
Eliza Prangley,Alexei Korennykh
Eliza Prangley
Mammalian cells are exquisitely sensitive to the presence of double-stranded RNA (dsRNA), a molecule that they interpret as a signal of viral presence requiring immediate attention. Upon sensing dsRNA cells activate the innate immune respon...
Hyogyung Shin,Yoori Kim
Hyogyung Shin
In the human cell nucleus, dynamically organized chromatin is the substrate for gene regulation, DNA replication, and repair. A central mechanism of DNA loop formation is an ATPase motor cohesin-mediated loop extrusion. The cohesin complexe...
Challenges and opportunities for circRNA identification and delivery [0.03%]
环状circRNA的识别与递送面临的挑战与机遇
Jiani Dong,Zhuoer Zeng,Ying Huang et al.
Jiani Dong et al.
Circular RNAs (circRNAs) are evolutionarily conserved noncoding RNAs with tissue-specific expression patterns, and exert unique cellular functions that have the potential to become biomarkers in therapeutic applications. Therefore, accurate...
Overview of physiological, biochemical, and regulatory aspects of nitrogen fixation in Azotobacter vinelandii [0.03%]
Azotobacter vinelandii固氮的生理生化及调控概述
Julia S Martin Del Campo,Jack Rigsbee,Marcelo Bueno Batista et al.
Julia S Martin Del Campo et al.
Understanding how Nature accomplishes the reduction of inert nitrogen gas to form metabolically tractable ammonia at ambient temperature and pressure has challenged scientists for more than a century. Such an understanding is a key aspect t...
Milk glycan metabolism by intestinal bifidobacteria: insights from comparative genomics [0.03%]
乳糖聚糖代谢的肠道双歧杆菌：来自比较基因组学的见解
Aleksandr A Arzamasov,Andrei L Osterman
Aleksandr A Arzamasov
Bifidobacteria are early colonizers of the human neonatal gut and provide multiple health benefits to the infant, including inhibiting the growth of enteropathogens and modulating the immune system. Certain Bifidobacterium species prevail i...