Mitochondrial sirtuin 3 and role of natural compounds: the effect of post-translational modifications on cellular metabolism [0.03%]
线粒体长寿蛋白sirtuin 3及其天然产物调控剂的作用：表观遗传修饰对细胞代谢的影响
Francesca Oppedisano,Salvatore Nesci,Anna Spagnoletta
Francesca Oppedisano
Sirtuins (SIRTs) are a family of proteins with enzymatic activity. In particular, they are a family of class III NAD+-dependent histone deacetylases and ADP-ribosyltransferases. NAD+-dependent deac(et)ylase activities catalyzed by sirtuin i...
The biogenesis of potassium transporters: implications of disease-associated mutations [0.03%]
钾转运蛋白的生物发生：疾病相关突变的影响
Morgan Kok,Jeffrey L Brodsky
Morgan Kok
The concentration of intracellular and extracellular potassium is tightly regulated due to the action of various ion transporters, channels, and pumps, which reside primarily in the kidney. Yet, potassium transporters and cotransporters pla...
Shane Stoeber,Holly Godin,Cheng Xu et al.
Shane Stoeber et al.
Chromatin is densely packed with nucleosomes, which limits the accessibility of many chromatin-associated proteins. Pioneer factors (PFs) are usually viewed as a special group of sequence-specific transcription factors (TFs) that can recogn...
Molecular insights into the prototypical single-stranded DNA-binding protein from E. coli [0.03%]
大肠杆菌单链DNA结合蛋白的分子机制研究进展
Nina J Bonde,Alexander G Kozlov,Michael M Cox et al.
Nina J Bonde et al.
The SSB protein of Escherichia coli functions to bind single-stranded DNA wherever it occurs during DNA metabolism. Depending upon conditions, SSB occurs in several different binding modes. In the course of its function, SSB diffuses on ssD...
Elucidating the chain of command: our current understanding of critical target genes for p53-mediated tumor suppression [0.03%]
阐明五三蛋白介导的肿瘤抑制关键靶基因的调控链
Alexandra Indeglia,Maureen E Murphy
Alexandra Indeglia
TP53 encodes a transcription factor that is centrally-involved in several pathways, including the control of metabolism, the stress response, DNA repair, cell cycle arrest, senescence, programmed cell death, and others. Since the discovery ...
Approaching the catalytic mechanism of protein lysine methyltransferases by biochemical and simulation techniques [0.03%]
生物化学和模拟技术在蛋白质赖氨酸甲基转移酶催化机制研究中的应用
Philipp Schnee,Jürgen Pleiss,Albert Jeltsch
Philipp Schnee
Protein lysine methyltransferases (PKMTs) transfer up to three methyl groups to the side chains of lysine residues in proteins and fulfill important regulatory functions by controlling protein stability, localization and protein/protein int...
Epigenome editing for targeted DNA (de)methylation: a new perspective in modulating gene expression [0.03%]
表观基因组编辑针对性DNA(去)甲基化：调控基因表达的新视角
Karishma Seem,Simardeep Kaur,Suresh Kumar et al.
Karishma Seem et al.
Traditionally, it has been believed that inheritance is driven as phenotypic variations resulting from changes in DNA sequence. However, this paradigm has been challenged and redefined in the contemporary era of epigenetics. The changes in ...
Collaborators or competitors: the communication between RNA polymerase II and the nucleosome during eukaryotic transcription [0.03%]
合作者还是竞争者：真核转录过程中RNA聚合酶II和核小体之间的相互作用
Haley A Hardtke,Y Jessie Zhang
Haley A Hardtke
Decades of scientific research have been devoted to unraveling the intricacies of eukaryotic transcription since the groundbreaking discovery of eukaryotic RNA polymerases in the late 1960s. RNA polymerase II, the polymerase responsible for...
Hemoglobin wonders: a fascinating gas transporter dive into molluscs [0.03%]
血红蛋白的奇妙之旅：探索软体动物中的气体运输器
Weifeng Zhang,Yang Zhang,Xizhi Shi et al.
Weifeng Zhang et al.
Hemoglobin (Hb) has been identified in at least 14 molluscan taxa so far. Research spanning over 130 years on molluscan Hbs focuses on their genes, protein structures, functions, and evolution. Molluscan Hbs are categorized into single-, tw...
Insights into the metabolism, signaling, and physiological effects of 2',3'-cyclic nucleotide monophosphates in bacteria [0.03%]
细菌中2',3'-环核苷酸单磷酸盐的代谢、信号传导和生理效应研究进展
Nick J Marotta,Emily E Weinert
Nick J Marotta
2',3'-cyclic nucleotide monophosphates (2',3'-cNMPs) have been discovered within both prokaryotes and eukaryotes in the past decade and a half, raising questions about their conserved existence in cells. In plants and mammals, wounding has ...