Discovery, functional characterization, and structural studies of the NRPS-independent siderophore synthetases [0.03%]
非NRPS依赖的铁载体合成酶的发现，功能鉴定及结构研究
Ketan D Patel,Mercedes B Fisk,Andrew M Gulick
Ketan D Patel
To adapt to low-iron environments, many bacteria produce siderophores, low molecular weight iron chelators that are secreted into the environment where they bind ferric iron. The production of siderophore uptake systems then allows retrieva...
Catalase-peroxidase (KatG): a potential frontier in tuberculosis drug development [0.03%]
过氧化氢酶（KatG）：结核病药物开发的潜在新领域
Aimin Liu
Aimin Liu
Mycobacterium tuberculosis (Mtb) depends on the bifunctional enzyme catalase-peroxidase (KatG) for survival within the host. KatG exhibits both catalase and peroxidase activities, serving distinct yet critical roles. While its peroxidase ac...
The common chemical logic of 'bridged' peroxo species in mononuclear non-heme iron systems [0.03%]
单核非血红素铁体系中“连接”过氧物种的共同化学规律
Kirklin L McWhorter,Vatsal Purohit,Joseph A Ambarian et al.
Kirklin L McWhorter et al.
Mononuclear non-heme iron enzymes catalyze a wide array of important oxidative transformations. They are correspondingly diverse in both structure and mechanism. Despite significant evolutionary distance, it is becoming increasingly apparen...
A structural view of nickel-pincer nucleotide cofactor-related biochemistry [0.03%]
镍-夹捏核苷酸辅因子相关生物化学的结构观点
Santhosh Gatreddi,Shramana Chatterjee,Aiko Turmo et al.
Santhosh Gatreddi et al.
The nickel-pincer nucleotide (NPN) is an organometallic cofactor that was first discovered in lactate racemase from Lactiplantibacillus plantarum. In this review, we provide an overview on the structure-function relationships of enzymes tha...
Structures, mechanisms, and kinetic advantages of the SgrAI filament forming mechanism [0.03%]
斯蒂特分子云中Sgr A*喷流形成的结构、机制及动力学优势
Nancy C Horton,Dmitry Lyumkis
Nancy C Horton
This review documents investigations leading to the unprecedented discovery of filamentation as a mode of enzyme regulation in the type II restriction endonuclease SgrAI. Filamentation is defined here as linear or helical polymerization of ...
Chellapandi Paulchamy,Sreekutty Vakkattuthundi Premji,Saranya Shanmugam
Chellapandi Paulchamy
Space exploration and research are uncovering the potential for terrestrial life to survive in outer space, as well as the environmental factors that affect life during interplanetary transfer. The presence of methane in the Martian atmosph...
Evolution, classification, and mechanisms of transport, activity regulation, and substrate specificity of ZIP metal transporters [0.03%]
ZIP锌指蛋白金属离子转运家族的进化、分类及作用机制研究进展
Jian Hu,Yuhan Jiang
Jian Hu
The Zrt/Irt-like protein (ZIP) family consists of ubiquitously expressed divalent d-block metal transporters that play central roles in the uptake, secretion, excretion, and distribution of several essential and toxic metals in living organ...
Mechanisms of immune evasion by Mycobacterium tuberculosis: the impact of T7SS and cell wall lipids on host defenses [0.03%]
结核分枝杆菌免疫逃逸机制：T7SS及细胞壁脂质对宿主防御的影响
Asrar Ahmad Malik,Mohd Shariq,Javaid Ahmad Sheikh et al.
Asrar Ahmad Malik et al.
Mycobacterium tuberculosis (M. tb) is one of the most successful human pathogens, causing a severe and widespread infectious disease. The frequent emergence of multidrug-resistant (MDR) strains has exacerbated this public health crisis, par...
The general transcription factors (GTFs) of RNA polymerase II and their roles in plant development and stress responses [0.03%]
RNA聚合酶II的通用转录因子(GTFS)及其在植物发育和逆境响应中的作用
Shivam Sharma,Sanjay Kapoor,Athar Ansari et al.
Shivam Sharma et al.
In eukaryotes, general transcription factors (GTFs) enable recruitment of RNA polymerase II (RNA Pol II) to core promoters to facilitate initiation of transcription. Extensive research in mammals and yeast has unveiled their significance in...
Exercise training and changes in skeletal muscle mitochondrial proteins: from blots to "omics" [0.03%]
运动训练与骨骼肌线粒体蛋白变化：从印记到“组学”研究
Elizabeth G Reisman,Nikeisha J Caruana,David J Bishop
Elizabeth G Reisman
Mitochondria are essential, membrane-enclosed organelles that consist of ∼1100 different proteins, which allow for many diverse functions critical to maintaining metabolism. Highly metabolic tissues, such as skeletal muscle, have a high mi...