Galectins: a promising arsenal of novel immunotherapeutic weapons in oncology tunned by an array of non-coding RNAs [0.03%]
糖蛋白凝集素：由一系列非编码RNA调控的新型免疫治疗武器在肿瘤学中的应用展望
Alyaa Dawoud,Tasneem Abaza,Yomna Youssef et al.
Alyaa Dawoud et al.
Galectins, a family of sugar-binding proteins, play a multifaceted role in human health and disease. They do not only regulate cellular processes but also influence tumor development and progression by promoting tumor growth, angiogenesis, ...
From serendipity to strategy: molecular glue degraders in cancer therapeutics [0.03%]
从偶然到策略：“分子胶”降解剂在癌症治疗中的应用
Sarah Darling,Ilirjana Bajrami,Stephen C West
Sarah Darling
Targeted protein degradation is an elegant therapeutic strategy that harnesses the cell's own degradation machinery to selectively eliminate target proteins. This approach marks a paradigm shift in drug discovery, moving beyond traditional ...
Mitochondrial medicine in fatty acid oxidation disorders: insights from genetic discoveries and patient cell models [0.03%]
遗传学发现和患者细胞模型在脂肪酸氧化障碍中的线粒体医学中的见解
Rikke Katrine Jentoft Olsen
Rikke Katrine Jentoft Olsen
Mitochondrial fatty acid oxidation (mFAO) disorders are caused by genetic variants in mFAO enzymes, their electron transporters, and cofactors. The clinical spectrum is heterogeneous, ranging from multi-organ failure and early death to mild...
Molecular insights into nucleic acid triplexes: methodologies and biological applications [0.03%]
核酸三链体的分子见解：方法与生物应用
Jack W Klose,Gerardo Urbina,Tara L Pukala
Jack W Klose
Triplex DNA structures form through the binding of a third oligonucleotide strand to the major groove of canonical double-stranded DNA at sites of extended polypurine sequence. Although they are known to be favored with certain sequence spe...
Breakthroughs in the development of antibiotics, antifungals and antiparasitics targeting the pathogens' respiratory chain [0.03%]
针对病原体呼吸链的抗生素、抗真菌药和抗寄生虫药研发中的突破性进展
Jennifer M Sorescu,Martín A González-Montalvo,Ming Yuan et al.
Jennifer M Sorescu et al.
The aerobic respiratory chain is vital to bacterial and eukaryotic cell energy transformation. Embedded in the mitochondrial inner membrane and the bacterial plasma membrane, the respiratory chain couples sequential redox reactions with ion...
Sumner's legacy: a century of urease crystals and recent structural advances [0.03%]
桑姆尔的贡献：尿酶世纪结晶成就及最新结构研究进展
Robert P Hausinger
Robert P Hausinger
In 1926, James B. Sumner crystallized jack bean urease-the first enzyme to be obtained in crystalline form-thus demonstrating that enzymes are proteinaceous. To honor the 100-year anniversary of that momentous event, this review highlights ...
Fujing Wei,Nan Qin,Yunling Chen et al.
Fujing Wei et al.
Autophagy, a highly conserved catabolic pathway in eukaryotes, is essential for cellular survival during starvation and for maintaining cellular homeostasis. Central to autophagy is the de novo formation of double-membrane autophagosomes, w...
B-cell lymphoma 6 in breast cancer: molecular mechanisms and clinical significance [0.03%]
B细胞淋巴瘤6在乳腺癌中的分子机制及临床意义
Frank Louwen,Andreas Ritter,Nina-Naomi Kreis et al.
Frank Louwen et al.
Breast cancer is the most frequent malignancy and the most common cause of cancer-related death in women worldwide. Despite remarkable improvements in therapy, the prognosis of advanced breast cancer remains poor. Further investigations are...
Protein targeting to the ER membrane: multiple pathways and shared machinery [0.03%]
蛋白质向内质网膜定位：多种途径和共享的设备
Wendy N Sánchez,Arnold J M Driessen,Christian A M Wilson
Wendy N Sánchez
The endoplasmic reticulum (ER) serves as a central hub for protein production and sorting in eukaryotic cells, processing approximately one-third of the cellular proteome. Protein targeting to the ER occurs through multiple pathways that op...
Unraveling the multifaceted role of extracellular DNA (eDNA) of biofilm in bacterial physiology, biofilm formation, and matrixome architecture [0.03%]
揭秘生物被膜细菌外源DNA（eDNA）在细菌生理、生物被膜形成及矩阵结构中的多方面作用
Sonalin Rath,Shourat Fatma,Surajit Das
Sonalin Rath
Bacterial biofilms consist of bacterial communities embedded in a self-produced extracellular matrix (EM) known as the matrixome. The matrixome primarily comprises extracellular polymeric substances (EPS) and other elements. EPS encompassin...